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Gene: BMP2 |
Gene summary for BMP2 |
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Gene information | Species | Human | Gene symbol | BMP2 | Gene ID | 650 |
Gene name | bone morphogenetic protein 2 | |
Gene Alias | BDA2 | |
Cytomap | 20p12.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | C8C060 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
650 | BMP2 | AEH-subject3 | Human | Endometrium | AEH | 3.87e-05 | -1.08e-01 | -0.2576 |
650 | BMP2 | AEH-subject4 | Human | Endometrium | AEH | 1.17e-02 | -1.08e-01 | -0.2657 |
650 | BMP2 | AEH-subject5 | Human | Endometrium | AEH | 3.87e-05 | -1.04e-01 | -0.2953 |
650 | BMP2 | EEC-subject3 | Human | Endometrium | EEC | 2.79e-05 | -4.58e-02 | -0.2525 |
650 | BMP2 | EEC-subject5 | Human | Endometrium | EEC | 3.71e-04 | -1.08e-01 | -0.249 |
650 | BMP2 | GSM5276934 | Human | Endometrium | EEC | 1.36e-22 | 7.64e-01 | -0.0913 |
650 | BMP2 | GSM5276937 | Human | Endometrium | EEC | 5.33e-25 | 7.57e-01 | -0.0897 |
650 | BMP2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.67e-04 | -5.12e-02 | -0.1875 |
650 | BMP2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.51e-03 | -1.08e-01 | -0.1934 |
650 | BMP2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 8.23e-05 | -1.08e-01 | -0.1917 |
650 | BMP2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.97e-05 | -1.08e-01 | -0.1916 |
650 | BMP2 | LZE4T | Human | Esophagus | ESCC | 1.56e-02 | -4.23e-01 | 0.0811 |
650 | BMP2 | LZE8T | Human | Esophagus | ESCC | 4.52e-06 | -3.25e-01 | 0.067 |
650 | BMP2 | LZE24T | Human | Esophagus | ESCC | 1.37e-04 | -3.50e-01 | 0.0596 |
650 | BMP2 | P2T-E | Human | Esophagus | ESCC | 1.85e-13 | -2.72e-01 | 0.1177 |
650 | BMP2 | P5T-E | Human | Esophagus | ESCC | 1.23e-02 | -1.52e-02 | 0.1327 |
650 | BMP2 | P8T-E | Human | Esophagus | ESCC | 1.55e-03 | -8.66e-02 | 0.0889 |
650 | BMP2 | P11T-E | Human | Esophagus | ESCC | 4.01e-06 | 1.32e+00 | 0.1426 |
650 | BMP2 | P12T-E | Human | Esophagus | ESCC | 4.07e-09 | -3.44e-01 | 0.1122 |
650 | BMP2 | P15T-E | Human | Esophagus | ESCC | 3.32e-02 | -3.30e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007156014 | Endometrium | EEC | cellular response to transforming growth factor beta stimulus | 52/2168 | 250/18723 | 1.81e-05 | 3.41e-04 | 52 |
GO:003017713 | Endometrium | EEC | positive regulation of Wnt signaling pathway | 34/2168 | 140/18723 | 1.89e-05 | 3.50e-04 | 34 |
GO:000717814 | Endometrium | EEC | transmembrane receptor protein serine/threonine kinase signaling pathway | 68/2168 | 355/18723 | 1.90e-05 | 3.50e-04 | 68 |
GO:006113812 | Endometrium | EEC | morphogenesis of a branching epithelium | 41/2168 | 182/18723 | 1.96e-05 | 3.57e-04 | 41 |
GO:003209213 | Endometrium | EEC | positive regulation of protein binding | 24/2168 | 85/18723 | 2.29e-05 | 4.08e-04 | 24 |
GO:000176313 | Endometrium | EEC | morphogenesis of a branching structure | 43/2168 | 196/18723 | 2.47e-05 | 4.37e-04 | 43 |
GO:003367415 | Endometrium | EEC | positive regulation of kinase activity | 83/2168 | 467/18723 | 4.32e-05 | 7.10e-04 | 83 |
GO:007048216 | Endometrium | EEC | response to oxygen levels | 65/2168 | 347/18723 | 5.81e-05 | 9.03e-04 | 65 |
GO:00330021 | Endometrium | EEC | muscle cell proliferation | 50/2168 | 248/18723 | 6.08e-05 | 9.21e-04 | 50 |
GO:005067913 | Endometrium | EEC | positive regulation of epithelial cell proliferation | 43/2168 | 207/18723 | 9.53e-05 | 1.34e-03 | 43 |
GO:00609931 | Endometrium | EEC | kidney morphogenesis | 24/2168 | 93/18723 | 1.11e-04 | 1.52e-03 | 24 |
GO:005134817 | Endometrium | EEC | negative regulation of transferase activity | 52/2168 | 268/18723 | 1.23e-04 | 1.64e-03 | 52 |
GO:004876212 | Endometrium | EEC | mesenchymal cell differentiation | 47/2168 | 236/18723 | 1.35e-04 | 1.76e-03 | 47 |
GO:19007451 | Endometrium | EEC | positive regulation of p38MAPK cascade | 12/2168 | 32/18723 | 1.37e-04 | 1.78e-03 | 12 |
GO:004593617 | Endometrium | EEC | negative regulation of phosphate metabolic process | 77/2168 | 441/18723 | 1.45e-04 | 1.87e-03 | 77 |
GO:004586014 | Endometrium | EEC | positive regulation of protein kinase activity | 69/2168 | 386/18723 | 1.55e-04 | 1.96e-03 | 69 |
GO:001056317 | Endometrium | EEC | negative regulation of phosphorus metabolic process | 77/2168 | 442/18723 | 1.56e-04 | 1.97e-03 | 77 |
GO:001072012 | Endometrium | EEC | positive regulation of cell development | 56/2168 | 298/18723 | 1.68e-04 | 2.10e-03 | 56 |
GO:00487541 | Endometrium | EEC | branching morphogenesis of an epithelial tube | 33/2168 | 151/18723 | 2.23e-04 | 2.67e-03 | 33 |
GO:003629316 | Endometrium | EEC | response to decreased oxygen levels | 59/2168 | 322/18723 | 2.30e-04 | 2.73e-03 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043909 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa043504 | Endometrium | AEH | TGF-beta signaling pathway | 26/1197 | 108/8465 | 3.82e-03 | 2.18e-02 | 1.59e-02 | 26 |
hsa0439014 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0435011 | Endometrium | AEH | TGF-beta signaling pathway | 26/1197 | 108/8465 | 3.82e-03 | 2.18e-02 | 1.59e-02 | 26 |
hsa0439023 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa043502 | Endometrium | EEC | TGF-beta signaling pathway | 26/1237 | 108/8465 | 5.95e-03 | 3.12e-02 | 2.33e-02 | 26 |
hsa0439033 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa043503 | Endometrium | EEC | TGF-beta signaling pathway | 26/1237 | 108/8465 | 5.95e-03 | 3.12e-02 | 2.33e-02 | 26 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa043906 | Stomach | CAG with IM | Hippo signaling pathway | 21/640 | 157/8465 | 7.26e-03 | 4.05e-02 | 2.84e-02 | 21 |
hsa0439011 | Stomach | CAG with IM | Hippo signaling pathway | 21/640 | 157/8465 | 7.26e-03 | 4.05e-02 | 2.84e-02 | 21 |
hsa0439021 | Stomach | CSG | Hippo signaling pathway | 21/633 | 157/8465 | 6.42e-03 | 3.62e-02 | 2.61e-02 | 21 |
hsa0439031 | Stomach | CSG | Hippo signaling pathway | 21/633 | 157/8465 | 6.42e-03 | 3.62e-02 | 2.61e-02 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | FAP |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | FAP |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | Healthy |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | Healthy |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | Endometrium | AEH |
BMP2 | BMPR1B_BMPR2 | BMP2_BMPR1B_BMPR2 | BMP | Endometrium | AEH |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | Endometrium | EEC |
BMP2 | BMPR1A_ACVR2B | BMP2_BMPR1A_ACVR2B | BMP | Esophagus | ESCC |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | HNSCC | Precancer |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | Lung | AAH |
BMP2 | BMPR1B_BMPR2 | BMP2_BMPR1B_BMPR2 | BMP | Lung | AAH |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | THCA | ADJ |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | THCA | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMP2 | SNV | Missense_Mutation | rs759121274 | c.871N>T | p.Arg291Cys | p.R291C | P12643 | protein_coding | deleterious(0) | possibly_damaging(0.523) | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BMP2 | SNV | Missense_Mutation | novel | c.1099N>T | p.Ser367Cys | p.S367C | P12643 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
BMP2 | insertion | Frame_Shift_Ins | novel | c.1174_1175insAACTTACAGAACAGAGAGAAGGGAGGCTCCATGTTTATTTAAA | p.Gly392GlufsTer25 | p.G392Efs*25 | P12643 | protein_coding | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | ||
BMP2 | insertion | In_Frame_Ins | novel | c.1101_1102insGTCCACTTAGCTTGCATGATGACTGTTGCTTTGATGATGAAG | p.Ser367_Ala368insValHisLeuAlaCysMetMetThrValAlaLeuMetMetLys | p.S367_A368insVHLACMMTVALMMK | P12643 | protein_coding | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
BMP2 | insertion | Frame_Shift_Ins | novel | c.874_875insACGATGAGGT | p.Leu292HisfsTer5 | p.L292Hfs*5 | P12643 | protein_coding | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
BMP2 | SNV | Missense_Mutation | rs763897233 | c.73N>A | p.Val25Ile | p.V25I | P12643 | protein_coding | tolerated(1) | benign(0) | TCGA-VS-A957-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMP2 | SNV | Missense_Mutation | novel | c.113N>G | p.Ser38Trp | p.S38W | P12643 | protein_coding | deleterious(0.01) | benign(0.084) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMP2 | SNV | Missense_Mutation | novel | c.142G>A | p.Glu48Lys | p.E48K | P12643 | protein_coding | tolerated(0.21) | benign(0.009) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
BMP2 | SNV | Missense_Mutation | rs756645581 | c.292C>T | p.Arg98Trp | p.R98W | P12643 | protein_coding | tolerated(0.17) | possibly_damaging(0.571) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
BMP2 | SNV | Missense_Mutation | rs190569855 | c.979N>A | p.Gly327Arg | p.G327R | P12643 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | BUTAMBEN | BUTAMBEN | 22041064 | |
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | METHYL 4-AMINOBENZOATE | CHEMBL1927048 | 22041064 | |
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | DWP-431 | |||
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | BUTYL 4-ACETAMIDOBENZOATE | CHEMBL1321401 | 22041064 | |
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | ISOPROPYL 4-AMINOBENZOATE | CHEMBL1467165 | 22041064 |
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