GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190165323 | Oral cavity | EOLP | cellular response to peptide | 85/2218 | 359/18723 | 2.06e-10 | 2.06e-08 | 85 |
GO:003497624 | Oral cavity | EOLP | response to endoplasmic reticulum stress | 66/2218 | 256/18723 | 5.33e-10 | 4.31e-08 | 66 |
GO:200123525 | Oral cavity | EOLP | positive regulation of apoptotic signaling pathway | 41/2218 | 126/18723 | 6.68e-10 | 5.06e-08 | 41 |
GO:003158925 | Oral cavity | EOLP | cell-substrate adhesion | 84/2218 | 363/18723 | 8.71e-10 | 6.29e-08 | 84 |
GO:004887226 | Oral cavity | EOLP | homeostasis of number of cells | 68/2218 | 272/18723 | 1.20e-09 | 8.27e-08 | 68 |
GO:001095224 | Oral cavity | EOLP | positive regulation of peptidase activity | 53/2218 | 197/18723 | 5.39e-09 | 2.91e-07 | 53 |
GO:001050622 | Oral cavity | EOLP | regulation of autophagy | 74/2218 | 317/18723 | 5.84e-09 | 3.07e-07 | 74 |
GO:004854526 | Oral cavity | EOLP | response to steroid hormone | 75/2218 | 339/18723 | 5.18e-08 | 1.92e-06 | 75 |
GO:009719125 | Oral cavity | EOLP | extrinsic apoptotic signaling pathway | 54/2218 | 219/18723 | 9.74e-08 | 3.36e-06 | 54 |
GO:003596724 | Oral cavity | EOLP | cellular response to topologically incorrect protein | 35/2218 | 116/18723 | 9.93e-08 | 3.40e-06 | 35 |
GO:000716017 | Oral cavity | EOLP | cell-matrix adhesion | 56/2218 | 233/18723 | 1.44e-07 | 4.68e-06 | 56 |
GO:001095024 | Oral cavity | EOLP | positive regulation of endopeptidase activity | 46/2218 | 179/18723 | 2.35e-07 | 7.37e-06 | 46 |
GO:200124424 | Oral cavity | EOLP | positive regulation of intrinsic apoptotic signaling pathway | 22/2218 | 58/18723 | 2.98e-07 | 8.87e-06 | 22 |
GO:003462024 | Oral cavity | EOLP | cellular response to unfolded protein | 30/2218 | 96/18723 | 3.43e-07 | 1.01e-05 | 30 |
GO:007138325 | Oral cavity | EOLP | cellular response to steroid hormone stimulus | 49/2218 | 204/18723 | 8.63e-07 | 2.15e-05 | 49 |
GO:200105623 | Oral cavity | EOLP | positive regulation of cysteine-type endopeptidase activity | 39/2218 | 148/18723 | 9.60e-07 | 2.38e-05 | 39 |
GO:001050821 | Oral cavity | EOLP | positive regulation of autophagy | 33/2218 | 124/18723 | 5.07e-06 | 1.03e-04 | 33 |
GO:003235522 | Oral cavity | EOLP | response to estradiol | 36/2218 | 141/18723 | 5.44e-06 | 1.08e-04 | 36 |
GO:000170123 | Oral cavity | EOLP | in utero embryonic development | 72/2218 | 367/18723 | 1.02e-05 | 1.83e-04 | 72 |
GO:006145824 | Oral cavity | EOLP | reproductive system development | 81/2218 | 427/18723 | 1.09e-05 | 1.93e-04 | 81 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04932210 | Esophagus | ESCC | Non-alcoholic fatty liver disease | 122/4205 | 155/8465 | 5.69e-14 | 1.59e-12 | 8.14e-13 | 122 |
hsa05169210 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa0521020 | Esophagus | ESCC | Colorectal cancer | 69/4205 | 86/8465 | 4.06e-09 | 4.13e-08 | 2.11e-08 | 69 |
hsa040689 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa0152110 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa042156 | Esophagus | ESCC | Apoptosis - multiple species | 25/4205 | 32/8465 | 9.13e-04 | 2.92e-03 | 1.49e-03 | 25 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0493238 | Esophagus | ESCC | Non-alcoholic fatty liver disease | 122/4205 | 155/8465 | 5.69e-14 | 1.59e-12 | 8.14e-13 | 122 |
hsa0516937 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0421037 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa05210110 | Esophagus | ESCC | Colorectal cancer | 69/4205 | 86/8465 | 4.06e-09 | 4.13e-08 | 2.11e-08 | 69 |
hsa0406814 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa0152115 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa0421511 | Esophagus | ESCC | Apoptosis - multiple species | 25/4205 | 32/8465 | 9.13e-04 | 2.92e-03 | 1.49e-03 | 25 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0493228 | Oral cavity | OSCC | Non-alcoholic fatty liver disease | 124/3704 | 155/8465 | 1.22e-20 | 1.37e-18 | 6.96e-19 | 124 |
hsa0516928 | Oral cavity | OSCC | Epstein-Barr virus infection | 144/3704 | 202/8465 | 1.08e-15 | 3.60e-14 | 1.83e-14 | 144 |
hsa0421018 | Oral cavity | OSCC | Apoptosis | 101/3704 | 136/8465 | 3.34e-13 | 7.00e-12 | 3.56e-12 | 101 |
hsa0521018 | Oral cavity | OSCC | Colorectal cancer | 66/3704 | 86/8465 | 3.99e-10 | 4.95e-09 | 2.52e-09 | 66 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCL2L11 | SNV | Missense_Mutation | novel | c.184N>A | p.Gly62Ser | p.G62S | O43521 | protein_coding | tolerated_low_confidence(0.09) | probably_damaging(0.998) | TCGA-AN-A03Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BCL2L11 | SNV | Missense_Mutation | | c.250A>G | p.Arg84Gly | p.R84G | O43521 | protein_coding | deleterious(0.03) | probably_damaging(0.966) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BCL2L11 | SNV | Missense_Mutation | novel | c.151N>A | p.Glu51Lys | p.E51K | O43521 | protein_coding | deleterious(0.04) | benign(0.025) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
BCL2L11 | SNV | Missense_Mutation | | c.458N>C | p.Arg153Pro | p.R153P | O43521 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BCL2L11 | SNV | Missense_Mutation | novel | c.587N>C | p.Arg196Thr | p.R196T | O43521 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.966) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
BCL2L11 | insertion | Frame_Shift_Ins | novel | c.391_392insAAGGCGGCGCGGCGCGCACCGG | p.Met131LysfsTer15 | p.M131Kfs*15 | O43521 | protein_coding | | | TCGA-BH-A0GY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyotxan | SD |
BCL2L11 | insertion | Frame_Shift_Ins | novel | c.393_394insTC | p.Ala132SerfsTer4 | p.A132Sfs*4 | O43521 | protein_coding | | | TCGA-BH-A0GY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyotxan | SD |
BCL2L11 | SNV | Missense_Mutation | | c.467N>A | p.Gly156Glu | p.G156E | O43521 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A2RO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BCL2L11 | deletion | Frame_Shift_Del | novel | c.479delA | p.Asn160ThrfsTer10 | p.N160Tfs*10 | O43521 | protein_coding | | | TCGA-C5-A2M2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BCL2L11 | insertion | Frame_Shift_Ins | novel | c.551_552insA | p.Arg185ThrfsTer80 | p.R185Tfs*80 | O43521 | protein_coding | | | TCGA-EA-A5FO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10018 | BCL2L11 | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TRANSCRIPTION FACTOR | | EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR | | 22426421 |
10018 | BCL2L11 | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TRANSCRIPTION FACTOR | | imatinib | IMATINIB | 24223824 |
10018 | BCL2L11 | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TRANSCRIPTION FACTOR | | IMATINIB | IMATINIB | 22426421 |
10018 | BCL2L11 | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TRANSCRIPTION FACTOR | | KERACYANIN | KERACYANIN | 17360708 |
10018 | BCL2L11 | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TRANSCRIPTION FACTOR | | corticosteroids | | 29282361 |