Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ROCK2

Gene summary for ROCK2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ROCK2

Gene ID

9475

Gene nameRho associated coiled-coil containing protein kinase 2
Gene AliasROCK-II
Cytomap2p25.1
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

O75116


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
9475ROCK2CCI_2HumanCervixCC8.74e-088.19e-010.5249
9475ROCK2CCI_3HumanCervixCC2.99e-036.37e-010.516
9475ROCK2HTA11_3410_2000001011HumanColorectumAD3.53e-02-2.80e-010.0155
9475ROCK2HTA11_1938_2000001011HumanColorectumAD1.56e-056.22e-01-0.0811
9475ROCK2HTA11_347_2000001011HumanColorectumAD1.96e-095.90e-01-0.1954
9475ROCK2HTA11_411_2000001011HumanColorectumSER1.02e-067.49e-01-0.2602
9475ROCK2HTA11_1391_2000001011HumanColorectumAD8.84e-035.18e-01-0.059
9475ROCK2HTA11_866_3004761011HumanColorectumAD2.59e-02-3.79e-010.096
9475ROCK2HTA11_8622_2000001021HumanColorectumSER4.22e-05-4.02e-010.0528
9475ROCK2HTA11_99999965104_69814HumanColorectumMSS1.07e-046.04e-010.281
9475ROCK2HTA11_99999971662_82457HumanColorectumMSS9.58e-055.75e-010.3859
9475ROCK2HTA11_99999974143_84620HumanColorectumMSS6.62e-075.58e-010.3005
9475ROCK2F007HumanColorectumFAP5.84e-031.44e-010.1176
9475ROCK2A002-C-010HumanColorectumFAP1.18e-041.78e-010.242
9475ROCK2A001-C-207HumanColorectumFAP2.09e-051.05e-010.1278
9475ROCK2A015-C-203HumanColorectumFAP6.50e-30-1.60e-01-0.1294
9475ROCK2A015-C-204HumanColorectumFAP1.22e-06-1.56e-01-0.0228
9475ROCK2A014-C-040HumanColorectumFAP2.49e-06-2.39e-01-0.1184
9475ROCK2A002-C-201HumanColorectumFAP1.25e-15-3.72e-020.0324
9475ROCK2A002-C-203HumanColorectumFAP4.43e-031.10e-010.2786
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001905828SkinAKviral life cycle74/1910317/187236.21e-121.27e-0974
GO:015011520SkinAKcell-substrate junction organization34/1910101/187231.38e-102.05e-0834
GO:003432919SkinAKcell junction assembly86/1910420/187231.95e-102.68e-0886
GO:190382927SkinAKpositive regulation of cellular protein localization64/1910276/187232.23e-103.00e-0864
GO:004851119SkinAKrhythmic process67/1910298/187233.47e-104.37e-0867
GO:004521626SkinAKcell-cell junction organization51/1910200/187234.51e-105.24e-0851
GO:000704419SkinAKcell-substrate junction assembly32/191095/187234.71e-105.26e-0832
GO:000640225SkinAKmRNA catabolic process56/1910232/187236.06e-106.41e-0856
GO:000989627SkinAKpositive regulation of catabolic process94/1910492/187231.32e-091.26e-0794
GO:000716326SkinAKestablishment or maintenance of cell polarity53/1910218/187231.32e-091.26e-0753
GO:001081026SkinAKregulation of cell-substrate adhesion53/1910221/187232.22e-092.02e-0753
GO:015011620SkinAKregulation of cell-substrate junction organization26/191071/187232.60e-092.33e-0726
GO:003425025SkinAKpositive regulation of cellular amide metabolic process43/1910162/187232.77e-092.40e-0743
GO:000762320SkinAKcircadian rhythm51/1910210/187232.80e-092.40e-0751
GO:003158920SkinAKcell-substrate adhesion74/1910363/187234.40e-093.30e-0774
GO:005254727SkinAKregulation of peptidase activity88/1910461/187234.65e-093.44e-0788
GO:000701528SkinAKactin filament organization85/1910442/187235.94e-094.14e-0785
GO:000195218SkinAKregulation of cell-matrix adhesion36/1910128/187231.02e-086.65e-0736
GO:005189319SkinAKregulation of focal adhesion assembly24/191066/187231.24e-087.83e-0724
GO:009010919SkinAKregulation of cell-substrate junction assembly24/191066/187231.24e-087.83e-0724
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0513020CervixCCPathogenic Escherichia coli infection63/1267197/84659.28e-102.00e-081.19e-0863
hsa0541720CervixCCLipid and atherosclerosis65/1267215/84656.47e-091.10e-076.52e-0865
hsa0516318CervixCCHuman cytomegalovirus infection65/1267225/84654.59e-086.47e-073.83e-0765
hsa0513120CervixCCShigellosis69/1267247/84657.64e-081.03e-066.10e-0769
hsa0520516CervixCCProteoglycans in cancer60/1267205/84659.13e-081.18e-067.00e-0760
hsa0451010CervixCCFocal adhesion59/1267203/84651.53e-071.84e-061.09e-0659
hsa0481016CervixCCRegulation of actin cytoskeleton64/1267229/84652.24e-072.59e-061.53e-0664
hsa0452020CervixCCAdherens junction33/126793/84656.99e-077.31e-064.32e-0633
hsa0453020CervixCCTight junction49/1267169/84651.87e-061.78e-051.05e-0549
hsa0467020CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa0513516CervixCCYersinia infection39/1267137/84653.27e-052.41e-041.42e-0439
hsa0407110CervixCCSphingolipid signaling pathway35/1267121/84655.70e-053.93e-042.32e-0435
hsa043609CervixCCAxon guidance47/1267182/84658.13e-055.38e-043.18e-0447
hsa043109CervixCCWnt signaling pathway43/1267171/84653.03e-041.64e-039.68e-0443
hsa04062CervixCCChemokine signaling pathway43/1267192/84653.60e-031.34e-027.91e-0343
hsa049218CervixCCOxytocin signaling pathway34/1267154/84651.12e-023.42e-022.02e-0234
hsa046115CervixCCPlatelet activation28/1267124/84651.50e-024.45e-022.63e-0228
hsa05130110CervixCCPathogenic Escherichia coli infection63/1267197/84659.28e-102.00e-081.19e-0863
hsa05417110CervixCCLipid and atherosclerosis65/1267215/84656.47e-091.10e-076.52e-0865
hsa0516319CervixCCHuman cytomegalovirus infection65/1267225/84654.59e-086.47e-073.83e-0765
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ROCK2SNVMissense_Mutationnovelc.3226N>Cp.Lys1076Glnp.K1076QO75116protein_codingdeleterious(0)probably_damaging(0.946)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ROCK2SNVMissense_Mutationrs747260728c.1715N>Ap.Arg572Glnp.R572QO75116protein_codingtolerated(0.38)benign(0.065)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ROCK2SNVMissense_Mutationc.3560N>Ap.Ser1187Asnp.S1187NO75116protein_codingtolerated(0.16)benign(0.097)TCGA-AN-A0FL-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ROCK2SNVMissense_Mutationc.4091G>Cp.Arg1364Thrp.R1364TO75116protein_codingdeleterious(0.01)benign(0.041)TCGA-AR-A0TX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ROCK2SNVMissense_Mutationc.1849N>Cp.Glu617Glnp.E617QO75116protein_codingtolerated(0.34)benign(0.083)TCGA-BH-A0HP-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapydoxorubicinSD
ROCK2SNVMissense_Mutationnovelc.2329N>Cp.Glu777Glnp.E777QO75116protein_codingtolerated(0.67)benign(0.028)TCGA-PE-A5DE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
ROCK2SNVMissense_Mutationnovelc.186N>Cp.Leu62Phep.L62FO75116protein_codingdeleterious(0.02)probably_damaging(0.95)TCGA-XX-A89A-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ROCK2insertionNonsense_Mutationnovelc.2665_2666insCAATTTAACTATAATCCAAp.Glu889AlafsTer3p.E889Afs*3O75116protein_codingTCGA-AR-A0U0-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ROCK2SNVMissense_Mutationnovelc.712A>Cp.Lys238Glnp.K238QO75116protein_codingdeleterious(0)probably_damaging(0.929)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ROCK2SNVMissense_Mutationc.2719N>Ap.Glu907Lysp.E907KO75116protein_codingdeleterious(0)probably_damaging(0.957)TCGA-DR-A0ZM-01Cervixcervical & endocervical cancerFemale<65III/IVUnspecificCisplatinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASEinhibitor178102655
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASEAR-12286VEROSUDIL
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASEBAY-613606CHEMBL541400
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASEAST-487AST-487
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASETHROMBINTHROMBIN16720831
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASEinhibitor178101973
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASEKD025
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASEVER-49009CHEMBL365617
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASETricyclic compound 4
9475ROCK2KINASE, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASEinhibitor310264692VEROSUDIL
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