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Gene: CD7 |
Gene summary for CD7 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CD7 | Gene ID | 924 |
Gene name | CD7 molecule | |
Gene Alias | GP40 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P09564 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
924 | CD7 | LZE2D | Human | Esophagus | HGIN | 1.57e-04 | 1.09e+00 | 0.0642 |
924 | CD7 | LZE4T | Human | Esophagus | ESCC | 1.39e-13 | 8.86e-01 | 0.0811 |
924 | CD7 | LZE7T | Human | Esophagus | ESCC | 4.27e-18 | 1.75e+00 | 0.0667 |
924 | CD7 | LZE8T | Human | Esophagus | ESCC | 4.06e-10 | 9.41e-01 | 0.067 |
924 | CD7 | LZE22D1 | Human | Esophagus | HGIN | 1.90e-05 | 7.28e-01 | 0.0595 |
924 | CD7 | LZE22T | Human | Esophagus | ESCC | 1.40e-06 | 1.34e+00 | 0.068 |
924 | CD7 | LZE24T | Human | Esophagus | ESCC | 8.01e-19 | 4.82e-01 | 0.0596 |
924 | CD7 | LZE6T | Human | Esophagus | ESCC | 1.00e-32 | 1.94e+00 | 0.0845 |
924 | CD7 | HCC1_Meng | Human | Liver | HCC | 1.40e-32 | 5.85e-02 | 0.0246 |
924 | CD7 | cirrhotic2 | Human | Liver | Cirrhotic | 2.04e-12 | 1.36e-01 | 0.0201 |
924 | CD7 | S014 | Human | Liver | HCC | 3.33e-42 | 2.54e+00 | 0.2254 |
924 | CD7 | S015 | Human | Liver | HCC | 3.91e-59 | 3.80e+00 | 0.2375 |
924 | CD7 | S016 | Human | Liver | HCC | 5.74e-81 | 3.62e+00 | 0.2243 |
924 | CD7 | C04 | Human | Oral cavity | OSCC | 1.84e-02 | 7.00e-01 | 0.2633 |
924 | CD7 | C21 | Human | Oral cavity | OSCC | 5.75e-35 | 1.06e+00 | 0.2678 |
924 | CD7 | C30 | Human | Oral cavity | OSCC | 3.79e-08 | 4.30e-01 | 0.3055 |
924 | CD7 | C38 | Human | Oral cavity | OSCC | 4.96e-15 | 2.85e+00 | 0.172 |
924 | CD7 | C46 | Human | Oral cavity | OSCC | 1.84e-11 | 2.80e-01 | 0.1673 |
924 | CD7 | C51 | Human | Oral cavity | OSCC | 7.96e-10 | 4.87e-01 | 0.2674 |
924 | CD7 | C57 | Human | Oral cavity | OSCC | 3.87e-03 | 2.39e-01 | 0.1679 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00303367 | Skin | AK | negative regulation of cell migration | 53/1910 | 344/18723 | 1.52e-03 | 1.10e-02 | 53 |
GO:00435169 | Skin | AK | regulation of DNA damage response, signal transduction by p53 class mediator | 10/1910 | 34/18723 | 1.57e-03 | 1.13e-02 | 10 |
GO:00455804 | Skin | AK | regulation of T cell differentiation | 27/1910 | 146/18723 | 1.64e-03 | 1.16e-02 | 27 |
GO:190225327 | Skin | AK | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 9/1910 | 29/18723 | 1.77e-03 | 1.23e-02 | 9 |
GO:009753010 | Skin | AK | granulocyte migration | 27/1910 | 148/18723 | 2.01e-03 | 1.35e-02 | 27 |
GO:19037076 | Skin | AK | negative regulation of hemopoiesis | 21/1910 | 106/18723 | 2.17e-03 | 1.44e-02 | 21 |
GO:00435184 | Skin | AK | negative regulation of DNA damage response, signal transduction by p53 class mediator | 6/1910 | 15/18723 | 2.48e-03 | 1.61e-02 | 6 |
GO:003022417 | Skin | AK | monocyte differentiation | 10/1910 | 36/18723 | 2.52e-03 | 1.63e-02 | 10 |
GO:000181917 | Skin | AK | positive regulation of cytokine production | 67/1910 | 467/18723 | 2.59e-03 | 1.67e-02 | 67 |
GO:00456576 | Skin | AK | positive regulation of monocyte differentiation | 5/1910 | 11/18723 | 3.00e-03 | 1.88e-02 | 5 |
GO:19021066 | Skin | AK | negative regulation of leukocyte differentiation | 20/1910 | 102/18723 | 3.10e-03 | 1.93e-02 | 20 |
GO:005237220 | Skin | AK | modulation by symbiont of entry into host | 12/1910 | 49/18723 | 3.13e-03 | 1.94e-02 | 12 |
GO:004800225 | Skin | AK | antigen processing and presentation of peptide antigen | 14/1910 | 62/18723 | 3.32e-03 | 2.03e-02 | 14 |
GO:001988325 | Skin | AK | antigen processing and presentation of endogenous antigen | 8/1910 | 26/18723 | 3.36e-03 | 2.05e-02 | 8 |
GO:190216518 | Skin | AK | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 6/1910 | 16/18723 | 3.63e-03 | 2.17e-02 | 6 |
GO:004312319 | Skin | AK | positive regulation of I-kappaB kinase/NF-kappaB signaling | 31/1910 | 186/18723 | 4.21e-03 | 2.46e-02 | 31 |
GO:00343419 | Skin | AK | response to interferon-gamma | 25/1910 | 141/18723 | 4.25e-03 | 2.48e-02 | 25 |
GO:00716226 | Skin | AK | regulation of granulocyte chemotaxis | 12/1910 | 51/18723 | 4.45e-03 | 2.58e-02 | 12 |
GO:00224087 | Skin | AK | negative regulation of cell-cell adhesion | 32/1910 | 196/18723 | 5.06e-03 | 2.84e-02 | 32 |
GO:19026245 | Skin | AK | positive regulation of neutrophil migration | 8/1910 | 28/18723 | 5.55e-03 | 3.05e-02 | 8 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | ADJ |
APP | CD74 | APP_CD74 | APP | Breast | ADJ |
APP | CD74 | APP_CD74 | APP | Breast | DCIS |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | DCIS |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | DCIS |
APP | CD74 | APP_CD74 | APP | Breast | Healthy |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Healthy |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Healthy |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | IDC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | IDC |
APP | CD74 | APP_CD74 | APP | Breast | IDC |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Precancer |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Precancer |
APP | CD74 | APP_CD74 | APP | Breast | Precancer |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | ADJ |
APP | CD74 | APP_CD74 | APP | Cervix | ADJ |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | CC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | CC |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD7 | SNV | Missense_Mutation | novel | c.586N>T | p.Val196Leu | p.V196L | P09564 | protein_coding | tolerated(0.48) | benign(0.007) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |
CD7 | SNV | Missense_Mutation | novel | c.434N>T | p.Ala145Val | p.A145V | P09564 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CD7 | SNV | Missense_Mutation | novel | c.481C>T | p.Leu161Phe | p.L161F | P09564 | protein_coding | tolerated(0.87) | possibly_damaging(0.766) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CD7 | insertion | Frame_Shift_Ins | novel | c.138_139insT | p.Thr47TyrfsTer117 | p.T47Yfs*117 | P09564 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
CD7 | insertion | In_Frame_Ins | novel | c.137_138insTCC | p.Ile46_Thr47insPro | p.I46_T47insP | P09564 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
CD7 | SNV | Missense_Mutation | rs149247674 | c.307C>T | p.Arg103Cys | p.R103C | P09564 | protein_coding | deleterious(0.05) | probably_damaging(0.912) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CD7 | SNV | Missense_Mutation | c.239C>T | p.Thr80Met | p.T80M | P09564 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD7 | SNV | Missense_Mutation | rs751672673 | c.677N>T | p.Ser226Leu | p.S226L | P09564 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CD7 | SNV | Missense_Mutation | c.637G>A | p.Asp213Asn | p.D213N | P09564 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CD7 | SNV | Missense_Mutation | c.222N>A | p.Asp74Glu | p.D74E | P09564 | protein_coding | tolerated(0.11) | benign(0.229) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
924 | CD7 | DRUGGABLE GENOME | CD7.CAR/28zeta CAR T cells | |||
924 | CD7 | DRUGGABLE GENOME | Anti-CD7 CAR-T cells |
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