GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190241010 | Thyroid | PTC | mitotic cytokinetic process | 17/5968 | 23/18723 | 4.25e-05 | 3.87e-04 | 17 |
GO:00901745 | Thyroid | PTC | organelle membrane fusion | 55/5968 | 110/18723 | 5.64e-05 | 4.99e-04 | 55 |
GO:004311219 | Thyroid | PTC | receptor metabolic process | 77/5968 | 166/18723 | 6.21e-05 | 5.47e-04 | 77 |
GO:00328866 | Thyroid | PTC | regulation of microtubule-based process | 105/5968 | 240/18723 | 6.91e-05 | 6.03e-04 | 105 |
GO:009006816 | Thyroid | PTC | positive regulation of cell cycle process | 103/5968 | 236/18723 | 9.03e-05 | 7.50e-04 | 103 |
GO:00995637 | Thyroid | PTC | modification of synaptic structure | 16/5968 | 22/18723 | 9.98e-05 | 8.15e-04 | 16 |
GO:00991738 | Thyroid | PTC | postsynapse organization | 77/5968 | 168/18723 | 1.01e-04 | 8.25e-04 | 77 |
GO:00467558 | Thyroid | PTC | viral budding | 18/5968 | 26/18723 | 1.02e-04 | 8.25e-04 | 18 |
GO:00616408 | Thyroid | PTC | cytoskeleton-dependent cytokinesis | 50/5968 | 100/18723 | 1.20e-04 | 9.59e-04 | 50 |
GO:19052445 | Thyroid | PTC | regulation of modification of synaptic structure | 11/5968 | 13/18723 | 1.34e-04 | 1.05e-03 | 11 |
GO:00717636 | Thyroid | PTC | nuclear membrane organization | 21/5968 | 33/18723 | 1.73e-04 | 1.32e-03 | 21 |
GO:1903902110 | Thyroid | PTC | positive regulation of viral life cycle | 19/5968 | 29/18723 | 2.02e-04 | 1.51e-03 | 19 |
GO:00619527 | Thyroid | PTC | midbody abscission | 13/5968 | 17/18723 | 2.05e-04 | 1.52e-03 | 13 |
GO:005122514 | Thyroid | PTC | spindle assembly | 56/5968 | 117/18723 | 2.17e-04 | 1.60e-03 | 56 |
GO:009016916 | Thyroid | PTC | regulation of spindle assembly | 17/5968 | 25/18723 | 2.25e-04 | 1.64e-03 | 17 |
GO:19048967 | Thyroid | PTC | ESCRT complex disassembly | 9/5968 | 10/18723 | 2.41e-04 | 1.74e-03 | 9 |
GO:19049037 | Thyroid | PTC | ESCRT III complex disassembly | 9/5968 | 10/18723 | 2.41e-04 | 1.74e-03 | 9 |
GO:00069985 | Thyroid | PTC | nuclear envelope organization | 27/5968 | 47/18723 | 2.57e-04 | 1.84e-03 | 27 |
GO:00991754 | Thyroid | PTC | regulation of postsynapse organization | 45/5968 | 90/18723 | 2.57e-04 | 1.84e-03 | 45 |
GO:00109486 | Thyroid | PTC | negative regulation of cell cycle process | 122/5968 | 294/18723 | 2.94e-04 | 2.08e-03 | 122 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHM | SNV | Missense_Mutation | rs746300399 | c.10N>G | p.Thr4Ala | p.T4A | P24386 | protein_coding | tolerated(0.05) | benign(0.001) | TCGA-A2-A3XY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
CHM | SNV | Missense_Mutation | | c.741N>G | p.Ile247Met | p.I247M | P24386 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CHM | SNV | Missense_Mutation | | c.1462C>T | p.Arg488Trp | p.R488W | P24386 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHM | SNV | Missense_Mutation | | c.158N>T | p.Ser53Leu | p.S53L | P24386 | protein_coding | deleterious(0.01) | benign(0.408) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD |
CHM | SNV | Missense_Mutation | | c.1093C>A | p.Leu365Ile | p.L365I | P24386 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHM | SNV | Missense_Mutation | novel | c.888G>A | p.Met296Ile | p.M296I | P24386 | protein_coding | deleterious(0.02) | possibly_damaging(0.551) | TCGA-LL-A9Q3-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Immunotherapy | herceptin | CR |
CHM | SNV | Missense_Mutation | novel | c.1061N>A | p.Gly354Asp | p.G354D | P24386 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CHM | SNV | Missense_Mutation | novel | c.180N>T | p.Lys60Asn | p.K60N | P24386 | protein_coding | deleterious(0.04) | benign(0.02) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CHM | SNV | Missense_Mutation | | c.677G>T | p.Arg226Ile | p.R226I | P24386 | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CHM | SNV | Missense_Mutation | rs780111922 | c.1727N>G | p.Ser576Cys | p.S576C | P24386 | protein_coding | deleterious(0.01) | benign(0.324) | TCGA-Q1-A73S-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |