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Gene: ZPR1 |
Gene summary for ZPR1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZPR1 | Gene ID | 8882 |
| Gene name | ZPR1 zinc finger | |
| Gene Alias | GKAF | |
| Cytomap | 11q23.3 | |
| Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | O75312 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8882 | ZPR1 | LZE4T | Human | Esophagus | ESCC | 1.08e-09 | 1.77e-01 | 0.0811 |
| 8882 | ZPR1 | LZE7T | Human | Esophagus | ESCC | 2.04e-02 | 1.10e-01 | 0.0667 |
| 8882 | ZPR1 | LZE20T | Human | Esophagus | ESCC | 2.57e-08 | 1.29e-01 | 0.0662 |
| 8882 | ZPR1 | LZE24T | Human | Esophagus | ESCC | 7.00e-29 | 1.03e+00 | 0.0596 |
| 8882 | ZPR1 | LZE21T | Human | Esophagus | ESCC | 2.83e-02 | 1.09e-01 | 0.0655 |
| 8882 | ZPR1 | P1T-E | Human | Esophagus | ESCC | 3.28e-07 | 1.74e-01 | 0.0875 |
| 8882 | ZPR1 | P2T-E | Human | Esophagus | ESCC | 6.54e-15 | 2.70e-01 | 0.1177 |
| 8882 | ZPR1 | P4T-E | Human | Esophagus | ESCC | 1.80e-30 | 9.69e-01 | 0.1323 |
| 8882 | ZPR1 | P5T-E | Human | Esophagus | ESCC | 4.44e-26 | 5.86e-01 | 0.1327 |
| 8882 | ZPR1 | P8T-E | Human | Esophagus | ESCC | 6.71e-12 | 1.31e-01 | 0.0889 |
| 8882 | ZPR1 | P9T-E | Human | Esophagus | ESCC | 5.17e-21 | 4.25e-01 | 0.1131 |
| 8882 | ZPR1 | P10T-E | Human | Esophagus | ESCC | 2.62e-23 | 5.26e-01 | 0.116 |
| 8882 | ZPR1 | P11T-E | Human | Esophagus | ESCC | 1.56e-13 | 7.15e-01 | 0.1426 |
| 8882 | ZPR1 | P12T-E | Human | Esophagus | ESCC | 1.11e-30 | 6.10e-01 | 0.1122 |
| 8882 | ZPR1 | P15T-E | Human | Esophagus | ESCC | 3.53e-13 | 3.55e-01 | 0.1149 |
| 8882 | ZPR1 | P16T-E | Human | Esophagus | ESCC | 3.04e-17 | 3.91e-01 | 0.1153 |
| 8882 | ZPR1 | P17T-E | Human | Esophagus | ESCC | 6.32e-03 | 4.76e-01 | 0.1278 |
| 8882 | ZPR1 | P19T-E | Human | Esophagus | ESCC | 2.40e-10 | 5.76e-01 | 0.1662 |
| 8882 | ZPR1 | P20T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.42e-01 | 0.1124 |
| 8882 | ZPR1 | P21T-E | Human | Esophagus | ESCC | 8.52e-41 | 9.79e-01 | 0.1617 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:004682415 | Oral cavity | LP | positive regulation of nucleocytoplasmic transport | 33/4623 | 62/18723 | 1.30e-06 | 3.16e-05 | 33 |
| GO:1901214110 | Oral cavity | LP | regulation of neuron death | 115/4623 | 319/18723 | 3.39e-06 | 7.19e-05 | 115 |
| GO:000626011 | Oral cavity | LP | DNA replication | 97/4623 | 260/18723 | 3.67e-06 | 7.75e-05 | 97 |
| GO:005117013 | Oral cavity | LP | import into nucleus | 65/4623 | 159/18723 | 4.78e-06 | 9.69e-05 | 65 |
| GO:005140218 | Oral cavity | LP | neuron apoptotic process | 91/4623 | 246/18723 | 1.07e-05 | 1.94e-04 | 91 |
| GO:000660612 | Oral cavity | LP | protein import into nucleus | 62/4623 | 155/18723 | 1.76e-05 | 3.04e-04 | 62 |
| GO:007084917 | Oral cavity | LP | response to epidermal growth factor | 26/4623 | 49/18723 | 1.84e-05 | 3.14e-04 | 26 |
| GO:000182411 | Oral cavity | LP | blastocyst development | 46/4623 | 106/18723 | 1.86e-05 | 3.15e-04 | 46 |
| GO:190458913 | Oral cavity | LP | regulation of protein import | 31/4623 | 63/18723 | 2.20e-05 | 3.58e-04 | 31 |
| GO:000008213 | Oral cavity | LP | G1/S transition of mitotic cell cycle | 80/4623 | 214/18723 | 2.30e-05 | 3.74e-04 | 80 |
| GO:004484313 | Oral cavity | LP | cell cycle G1/S phase transition | 88/4623 | 241/18723 | 2.62e-05 | 4.21e-04 | 88 |
| GO:003312019 | Oral cavity | LP | positive regulation of RNA splicing | 21/4623 | 37/18723 | 3.08e-05 | 4.74e-04 | 21 |
| GO:007136417 | Oral cavity | LP | cellular response to epidermal growth factor stimulus | 24/4623 | 45/18723 | 3.44e-05 | 5.18e-04 | 24 |
| GO:190459115 | Oral cavity | LP | positive regulation of protein import | 23/4623 | 43/18723 | 4.70e-05 | 6.64e-04 | 23 |
| GO:004230613 | Oral cavity | LP | regulation of protein import into nucleus | 29/4623 | 60/18723 | 6.10e-05 | 8.28e-04 | 29 |
| GO:004230714 | Oral cavity | LP | positive regulation of protein import into nucleus | 22/4623 | 41/18723 | 6.43e-05 | 8.67e-04 | 22 |
| GO:000699712 | Oral cavity | LP | nucleus organization | 51/4623 | 133/18723 | 3.22e-04 | 3.26e-03 | 51 |
| GO:004352316 | Oral cavity | LP | regulation of neuron apoptotic process | 73/4623 | 212/18723 | 8.87e-04 | 7.64e-03 | 73 |
| GO:190121515 | Oral cavity | LP | negative regulation of neuron death | 69/4623 | 208/18723 | 3.50e-03 | 2.34e-02 | 69 |
| GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZPR1 | SNV | Missense_Mutation | rs148642555 | c.1376N>A | p.Arg459Gln | p.R459Q | O75312 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(0.978) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
| ZPR1 | SNV | Missense_Mutation | novel | c.1170N>T | p.Lys390Asn | p.K390N | O75312 | protein_coding | deleterious(0.04) | probably_damaging(0.923) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
| ZPR1 | SNV | Missense_Mutation | novel | c.346N>A | p.Glu116Lys | p.E116K | O75312 | protein_coding | deleterious(0.02) | benign(0.41) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
| ZPR1 | SNV | Missense_Mutation | novel | c.509C>T | p.Ala170Val | p.A170V | O75312 | protein_coding | deleterious(0.05) | benign(0.053) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| ZPR1 | SNV | Missense_Mutation | c.233N>C | p.Phe78Ser | p.F78S | O75312 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZPR1 | SNV | Missense_Mutation | c.521N>T | p.Arg174Ile | p.R174I | O75312 | protein_coding | deleterious(0) | possibly_damaging(0.465) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZPR1 | SNV | Missense_Mutation | novel | c.763N>C | p.Phe255Leu | p.F255L | O75312 | protein_coding | deleterious(0) | possibly_damaging(0.694) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
| ZPR1 | SNV | Missense_Mutation | c.521G>T | p.Arg174Ile | p.R174I | O75312 | protein_coding | deleterious(0) | possibly_damaging(0.465) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
| ZPR1 | SNV | Missense_Mutation | rs529843898 | c.796N>A | p.Ala266Thr | p.A266T | O75312 | protein_coding | tolerated(0.16) | benign(0.095) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
| ZPR1 | SNV | Missense_Mutation | c.521N>T | p.Arg174Ile | p.R174I | O75312 | protein_coding | deleterious(0) | possibly_damaging(0.465) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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