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Gene: VDAC2 |
Gene summary for VDAC2 |
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Gene information | Species | Human | Gene symbol | VDAC2 | Gene ID | 7417 |
Gene name | voltage dependent anion channel 2 | |
Gene Alias | POR | |
Cytomap | 10q22.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P45880 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7417 | VDAC2 | GSM4909282 | Human | Breast | IDC | 1.20e-17 | 4.51e-01 | -0.0288 |
7417 | VDAC2 | GSM4909285 | Human | Breast | IDC | 7.38e-21 | 5.65e-01 | 0.21 |
7417 | VDAC2 | GSM4909287 | Human | Breast | IDC | 2.78e-02 | -1.87e-01 | 0.2057 |
7417 | VDAC2 | GSM4909288 | Human | Breast | IDC | 2.87e-02 | -1.26e-01 | 0.0988 |
7417 | VDAC2 | GSM4909294 | Human | Breast | IDC | 8.59e-07 | -1.91e-01 | 0.2022 |
7417 | VDAC2 | GSM4909295 | Human | Breast | IDC | 1.95e-04 | -4.33e-01 | 0.0898 |
7417 | VDAC2 | GSM4909296 | Human | Breast | IDC | 9.62e-14 | -4.67e-02 | 0.1524 |
7417 | VDAC2 | GSM4909297 | Human | Breast | IDC | 5.68e-25 | -2.34e-01 | 0.1517 |
7417 | VDAC2 | GSM4909301 | Human | Breast | IDC | 8.21e-24 | -5.13e-01 | 0.1577 |
7417 | VDAC2 | GSM4909302 | Human | Breast | IDC | 1.22e-03 | -2.34e-01 | 0.1545 |
7417 | VDAC2 | GSM4909309 | Human | Breast | IDC | 4.21e-04 | -1.79e-01 | 0.0483 |
7417 | VDAC2 | GSM4909311 | Human | Breast | IDC | 4.96e-47 | -5.51e-01 | 0.1534 |
7417 | VDAC2 | GSM4909312 | Human | Breast | IDC | 2.65e-18 | 6.76e-02 | 0.1552 |
7417 | VDAC2 | GSM4909313 | Human | Breast | IDC | 3.18e-06 | -1.79e-01 | 0.0391 |
7417 | VDAC2 | GSM4909315 | Human | Breast | IDC | 2.27e-13 | 3.46e-01 | 0.21 |
7417 | VDAC2 | GSM4909316 | Human | Breast | IDC | 2.54e-09 | 2.74e-01 | 0.21 |
7417 | VDAC2 | GSM4909318 | Human | Breast | IDC | 4.22e-06 | 3.05e-01 | 0.2031 |
7417 | VDAC2 | GSM4909319 | Human | Breast | IDC | 4.10e-66 | -4.58e-01 | 0.1563 |
7417 | VDAC2 | GSM4909320 | Human | Breast | IDC | 6.94e-12 | -5.62e-01 | 0.1575 |
7417 | VDAC2 | GSM4909321 | Human | Breast | IDC | 2.15e-28 | -9.56e-02 | 0.1559 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00973457 | Endometrium | AEH | mitochondrial outer membrane permeabilization | 10/2100 | 32/18723 | 1.94e-03 | 1.52e-02 | 10 |
GO:00469026 | Endometrium | AEH | regulation of mitochondrial membrane permeability | 15/2100 | 63/18723 | 3.50e-03 | 2.40e-02 | 15 |
GO:00905596 | Endometrium | AEH | regulation of membrane permeability | 17/2100 | 78/18723 | 5.18e-03 | 3.24e-02 | 17 |
GO:00357946 | Endometrium | AEH | positive regulation of mitochondrial membrane permeability | 11/2100 | 43/18723 | 6.60e-03 | 3.89e-02 | 11 |
GO:19021106 | Endometrium | AEH | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 10/2100 | 38/18723 | 7.62e-03 | 4.31e-02 | 10 |
GO:009719317 | Endometrium | EEC | intrinsic apoptotic signaling pathway | 80/2168 | 288/18723 | 3.35e-14 | 9.13e-12 | 80 |
GO:200123317 | Endometrium | EEC | regulation of apoptotic signaling pathway | 91/2168 | 356/18723 | 1.31e-13 | 3.28e-11 | 91 |
GO:200124217 | Endometrium | EEC | regulation of intrinsic apoptotic signaling pathway | 52/2168 | 164/18723 | 4.53e-12 | 8.00e-10 | 52 |
GO:000683915 | Endometrium | EEC | mitochondrial transport | 67/2168 | 254/18723 | 5.04e-11 | 7.03e-09 | 67 |
GO:200123417 | Endometrium | EEC | negative regulation of apoptotic signaling pathway | 53/2168 | 224/18723 | 2.53e-07 | 1.09e-05 | 53 |
GO:005125817 | Endometrium | EEC | protein polymerization | 63/2168 | 297/18723 | 1.24e-06 | 4.07e-05 | 63 |
GO:004325417 | Endometrium | EEC | regulation of protein-containing complex assembly | 83/2168 | 428/18723 | 1.44e-06 | 4.64e-05 | 83 |
GO:200124317 | Endometrium | EEC | negative regulation of intrinsic apoptotic signaling pathway | 28/2168 | 98/18723 | 3.84e-06 | 1.01e-04 | 28 |
GO:003227117 | Endometrium | EEC | regulation of protein polymerization | 50/2168 | 233/18723 | 1.07e-05 | 2.28e-04 | 50 |
GO:000700615 | Endometrium | EEC | mitochondrial membrane organization | 29/2168 | 116/18723 | 4.28e-05 | 7.09e-04 | 29 |
GO:000863715 | Endometrium | EEC | apoptotic mitochondrial changes | 27/2168 | 107/18723 | 6.52e-05 | 9.68e-04 | 27 |
GO:003133315 | Endometrium | EEC | negative regulation of protein-containing complex assembly | 32/2168 | 141/18723 | 1.32e-04 | 1.73e-03 | 32 |
GO:009734513 | Endometrium | EEC | mitochondrial outer membrane permeabilization | 11/2168 | 32/18723 | 6.20e-04 | 6.11e-03 | 11 |
GO:003227214 | Endometrium | EEC | negative regulation of protein polymerization | 19/2168 | 80/18723 | 1.64e-03 | 1.29e-02 | 19 |
GO:004690214 | Endometrium | EEC | regulation of mitochondrial membrane permeability | 16/2168 | 63/18723 | 1.77e-03 | 1.38e-02 | 16 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501714 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa042189 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0421610 | Breast | Precancer | Ferroptosis | 11/684 | 41/8465 | 2.95e-04 | 2.45e-03 | 1.88e-03 | 11 |
hsa0516618 | Breast | Precancer | Human T-cell leukemia virus 1 infection | 33/684 | 222/8465 | 4.29e-04 | 3.31e-03 | 2.53e-03 | 33 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501715 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0421814 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VDAC2 | SNV | Missense_Mutation | novel | c.731N>A | p.Arg244His | p.R244H | P45880 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VDAC2 | SNV | Missense_Mutation | c.698N>T | p.Asn233Ile | p.N233I | P45880 | protein_coding | deleterious(0.01) | possibly_damaging(0.582) | TCGA-AN-A0FD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VDAC2 | SNV | Missense_Mutation | novel | c.862C>G | p.Leu288Val | p.L288V | P45880 | protein_coding | tolerated(0.06) | benign(0.027) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VDAC2 | SNV | Missense_Mutation | novel | c.311A>C | p.Asp104Ala | p.D104A | P45880 | protein_coding | deleterious(0) | benign(0.14) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
VDAC2 | SNV | Missense_Mutation | rs759303647 | c.910G>A | p.Ala304Thr | p.A304T | P45880 | protein_coding | deleterious(0.02) | benign(0.221) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
VDAC2 | SNV | Missense_Mutation | c.223N>G | p.Thr75Ala | p.T75A | P45880 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-RU-A8FL-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
VDAC2 | SNV | Missense_Mutation | rs759303647 | c.910G>A | p.Ala304Thr | p.A304T | P45880 | protein_coding | deleterious(0.02) | benign(0.221) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VDAC2 | deletion | Frame_Shift_Del | c.177_178delNN | p.Lys60ValfsTer14 | p.K60Vfs*14 | P45880 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
VDAC2 | SNV | Missense_Mutation | novel | c.83N>A | p.Cys28Tyr | p.C28Y | P45880 | protein_coding | deleterious(0) | benign(0.245) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
VDAC2 | SNV | Missense_Mutation | novel | c.157G>T | p.Val53Leu | p.V53L | P45880 | protein_coding | tolerated(0.16) | benign(0.01) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7417 | VDAC2 | NA | OLESOXIME | OLESOXIME | ||
7417 | VDAC2 | NA | TCDD | 17998243 |
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