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Gene: ULK1 |
Gene summary for ULK1 |
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Gene information | Species | Human | Gene symbol | ULK1 | Gene ID | 8408 |
Gene name | unc-51 like autophagy activating kinase 1 | |
Gene Alias | ATG1 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | O75385 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8408 | ULK1 | HCC1_Meng | Human | Liver | HCC | 1.92e-22 | 5.09e-03 | 0.0246 |
8408 | ULK1 | HCC2_Meng | Human | Liver | HCC | 3.18e-08 | 4.85e-02 | 0.0107 |
8408 | ULK1 | HCC1 | Human | Liver | HCC | 2.70e-02 | 3.02e+00 | 0.5336 |
8408 | ULK1 | HCC2 | Human | Liver | HCC | 6.07e-10 | 2.67e+00 | 0.5341 |
8408 | ULK1 | S014 | Human | Liver | HCC | 1.58e-04 | 4.24e-01 | 0.2254 |
8408 | ULK1 | S015 | Human | Liver | HCC | 2.96e-05 | 4.89e-01 | 0.2375 |
8408 | ULK1 | S016 | Human | Liver | HCC | 1.62e-03 | 3.27e-01 | 0.2243 |
8408 | ULK1 | S027 | Human | Liver | HCC | 1.68e-07 | 8.42e-01 | 0.2446 |
8408 | ULK1 | S028 | Human | Liver | HCC | 1.30e-11 | 6.24e-01 | 0.2503 |
8408 | ULK1 | S029 | Human | Liver | HCC | 1.11e-06 | 5.11e-01 | 0.2581 |
8408 | ULK1 | C30 | Human | Oral cavity | OSCC | 2.30e-11 | 6.00e-01 | 0.3055 |
8408 | ULK1 | C38 | Human | Oral cavity | OSCC | 1.51e-06 | 9.25e-01 | 0.172 |
8408 | ULK1 | C43 | Human | Oral cavity | OSCC | 2.39e-15 | 2.66e-01 | 0.1704 |
8408 | ULK1 | C51 | Human | Oral cavity | OSCC | 5.20e-09 | 5.87e-01 | 0.2674 |
8408 | ULK1 | C57 | Human | Oral cavity | OSCC | 2.88e-02 | 2.63e-01 | 0.1679 |
8408 | ULK1 | C08 | Human | Oral cavity | OSCC | 3.18e-05 | 1.53e-01 | 0.1919 |
8408 | ULK1 | LN22 | Human | Oral cavity | OSCC | 2.98e-03 | 6.13e-01 | 0.1733 |
8408 | ULK1 | EOLP-1 | Human | Oral cavity | EOLP | 4.01e-04 | 1.27e-01 | -0.0202 |
8408 | ULK1 | SYSMH1 | Human | Oral cavity | OSCC | 6.71e-15 | 2.94e-01 | 0.1127 |
8408 | ULK1 | SYSMH2 | Human | Oral cavity | OSCC | 1.85e-06 | 1.58e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042594111 | Thyroid | PTC | response to starvation | 98/5968 | 197/18723 | 1.24e-07 | 2.41e-06 | 98 |
GO:004677716 | Thyroid | PTC | protein autophosphorylation | 110/5968 | 227/18723 | 1.25e-07 | 2.44e-06 | 110 |
GO:001810518 | Thyroid | PTC | peptidyl-serine phosphorylation | 143/5968 | 315/18723 | 2.94e-07 | 5.04e-06 | 143 |
GO:001820916 | Thyroid | PTC | peptidyl-serine modification | 151/5968 | 338/18723 | 4.61e-07 | 7.51e-06 | 151 |
GO:006156419 | Thyroid | PTC | axon development | 199/5968 | 467/18723 | 5.27e-07 | 8.53e-06 | 199 |
GO:0031667113 | Thyroid | PTC | response to nutrient levels | 201/5968 | 474/18723 | 7.00e-07 | 1.10e-05 | 201 |
GO:001821017 | Thyroid | PTC | peptidyl-threonine modification | 66/5968 | 125/18723 | 9.50e-07 | 1.43e-05 | 66 |
GO:001810717 | Thyroid | PTC | peptidyl-threonine phosphorylation | 62/5968 | 116/18723 | 1.16e-06 | 1.69e-05 | 62 |
GO:004867517 | Thyroid | PTC | axon extension | 63/5968 | 120/18723 | 2.14e-06 | 2.89e-05 | 63 |
GO:000740918 | Thyroid | PTC | axonogenesis | 178/5968 | 418/18723 | 2.17e-06 | 2.91e-05 | 178 |
GO:000004514 | Thyroid | PTC | autophagosome assembly | 54/5968 | 99/18723 | 2.46e-06 | 3.22e-05 | 54 |
GO:190503713 | Thyroid | PTC | autophagosome organization | 55/5968 | 103/18723 | 4.75e-06 | 5.79e-05 | 55 |
GO:005076716 | Thyroid | PTC | regulation of neurogenesis | 156/5968 | 364/18723 | 5.86e-06 | 7.05e-05 | 156 |
GO:190211516 | Thyroid | PTC | regulation of organelle assembly | 88/5968 | 186/18723 | 7.41e-06 | 8.65e-05 | 88 |
GO:004858819 | Thyroid | PTC | developmental cell growth | 106/5968 | 234/18723 | 1.07e-05 | 1.19e-04 | 106 |
GO:006056018 | Thyroid | PTC | developmental growth involved in morphogenesis | 105/5968 | 234/18723 | 1.94e-05 | 1.98e-04 | 105 |
GO:00507708 | Thyroid | PTC | regulation of axonogenesis | 74/5968 | 154/18723 | 1.96e-05 | 2.00e-04 | 74 |
GO:199013817 | Thyroid | PTC | neuron projection extension | 81/5968 | 172/18723 | 2.07e-05 | 2.08e-04 | 81 |
GO:00162395 | Thyroid | PTC | positive regulation of macroautophagy | 36/5968 | 63/18723 | 2.98e-05 | 2.86e-04 | 36 |
GO:006191210 | Thyroid | PTC | selective autophagy | 38/5968 | 68/18723 | 3.59e-05 | 3.36e-04 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501622 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0501022 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0413741 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0501721 | Liver | HCC | Spinocerebellar ataxia | 92/4020 | 143/8465 | 3.20e-05 | 1.88e-04 | 1.04e-04 | 92 |
hsa0421121 | Liver | HCC | Longevity regulating pathway | 61/4020 | 89/8465 | 4.46e-05 | 2.37e-04 | 1.32e-04 | 61 |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0501632 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0501032 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0413751 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0501731 | Liver | HCC | Spinocerebellar ataxia | 92/4020 | 143/8465 | 3.20e-05 | 1.88e-04 | 1.04e-04 | 92 |
hsa0421131 | Liver | HCC | Longevity regulating pathway | 61/4020 | 89/8465 | 4.46e-05 | 2.37e-04 | 1.32e-04 | 61 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0501628 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ULK1 | SNV | Missense_Mutation | novel | c.989N>T | p.Ser330Phe | p.S330F | O75385 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
ULK1 | SNV | Missense_Mutation | c.644T>C | p.Leu215Pro | p.L215P | O75385 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ULK1 | insertion | In_Frame_Ins | novel | c.247-1_247insTTTAAGTTTTGTATTTTTAGTAGA | p.Gln82_Glu83insPheLysPheCysIlePheSerArg | p.Q82_E83insFKFCIFSR | O75385 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ULK1 | deletion | Frame_Shift_Del | novel | c.1470delN | p.Ala491ProfsTer156 | p.A491Pfs*156 | O75385 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ULK1 | SNV | Missense_Mutation | novel | c.2048N>G | p.Glu683Gly | p.E683G | O75385 | protein_coding | tolerated(0.13) | benign(0.054) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ULK1 | SNV | Missense_Mutation | novel | c.448N>A | p.Ala150Thr | p.A150T | O75385 | protein_coding | tolerated(0.27) | benign(0.017) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ULK1 | SNV | Missense_Mutation | rs757530790 | c.2009N>C | p.Phe670Ser | p.F670S | O75385 | protein_coding | tolerated(0.17) | benign(0.074) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ULK1 | SNV | Missense_Mutation | c.1379N>G | p.Ser460Cys | p.S460C | O75385 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ULK1 | SNV | Missense_Mutation | rs761511646 | c.848N>T | p.Ser283Leu | p.S283L | O75385 | protein_coding | deleterious(0.02) | benign(0.132) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
ULK1 | SNV | Missense_Mutation | rs150697369 | c.1631C>G | p.Ser544Cys | p.S544C | O75385 | protein_coding | tolerated(0.08) | possibly_damaging(0.635) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8408 | ULK1 | KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | inhibitor | 249565893 |
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