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Gene: UCP2 |
Gene summary for UCP2 |
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Gene information | Species | Human | Gene symbol | UCP2 | Gene ID | 7351 |
Gene name | uncoupling protein 2 | |
Gene Alias | BMIQ4 | |
Cytomap | 11q13.4 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R5N5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7351 | UCP2 | GSM4909288 | Human | Breast | IDC | 4.04e-05 | 1.70e-01 | 0.0988 |
7351 | UCP2 | GSM4909290 | Human | Breast | IDC | 8.76e-11 | 4.50e-01 | 0.2096 |
7351 | UCP2 | GSM4909291 | Human | Breast | IDC | 2.73e-13 | 5.52e-01 | 0.1753 |
7351 | UCP2 | GSM4909297 | Human | Breast | IDC | 4.70e-02 | -8.43e-02 | 0.1517 |
7351 | UCP2 | GSM4909308 | Human | Breast | IDC | 2.54e-07 | 3.41e-01 | 0.158 |
7351 | UCP2 | GSM4909311 | Human | Breast | IDC | 2.31e-04 | -6.56e-02 | 0.1534 |
7351 | UCP2 | GSM4909312 | Human | Breast | IDC | 2.71e-04 | 2.66e-01 | 0.1552 |
7351 | UCP2 | GSM4909313 | Human | Breast | IDC | 1.70e-08 | 4.08e-01 | 0.0391 |
7351 | UCP2 | GSM4909316 | Human | Breast | IDC | 1.66e-07 | 5.51e-01 | 0.21 |
7351 | UCP2 | GSM4909319 | Human | Breast | IDC | 5.94e-07 | -9.74e-02 | 0.1563 |
7351 | UCP2 | GSM4909321 | Human | Breast | IDC | 2.98e-03 | 1.65e-01 | 0.1559 |
7351 | UCP2 | brca2 | Human | Breast | Precancer | 3.69e-10 | 4.51e-01 | -0.024 |
7351 | UCP2 | M2 | Human | Breast | IDC | 4.97e-06 | 4.94e-01 | 0.21 |
7351 | UCP2 | M5 | Human | Breast | IDC | 6.07e-07 | 6.86e-01 | 0.1598 |
7351 | UCP2 | NCCBC11 | Human | Breast | DCIS | 2.28e-02 | 4.39e-01 | 0.1232 |
7351 | UCP2 | NCCBC14 | Human | Breast | DCIS | 2.16e-06 | 3.36e-01 | 0.2021 |
7351 | UCP2 | NCCBC3 | Human | Breast | DCIS | 7.14e-04 | 3.23e-01 | 0.1198 |
7351 | UCP2 | NCCBC5 | Human | Breast | DCIS | 7.88e-09 | 4.19e-01 | 0.2046 |
7351 | UCP2 | P2 | Human | Breast | IDC | 8.72e-10 | 5.62e-01 | 0.21 |
7351 | UCP2 | DCIS2 | Human | Breast | DCIS | 4.17e-03 | -1.14e-01 | 0.0085 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001666 | Colorectum | AD | response to hypoxia | 86/3918 | 307/18723 | 1.77e-03 | 1.46e-02 | 86 |
GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
GO:0090087 | Colorectum | AD | regulation of peptide transport | 60/3918 | 202/18723 | 1.94e-03 | 1.58e-02 | 60 |
GO:0031669 | Colorectum | AD | cellular response to nutrient levels | 63/3918 | 215/18723 | 2.19e-03 | 1.73e-02 | 63 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0002791 | Colorectum | AD | regulation of peptide secretion | 59/3918 | 200/18723 | 2.50e-03 | 1.92e-02 | 59 |
GO:0090276 | Colorectum | AD | regulation of peptide hormone secretion | 58/3918 | 196/18723 | 2.51e-03 | 1.92e-02 | 58 |
GO:0002790 | Colorectum | AD | peptide secretion | 69/3918 | 242/18723 | 2.97e-03 | 2.22e-02 | 69 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0036293 | Colorectum | AD | response to decreased oxygen levels | 88/3918 | 322/18723 | 3.42e-03 | 2.49e-02 | 88 |
GO:0120162 | Colorectum | AD | positive regulation of cold-induced thermogenesis | 32/3918 | 97/18723 | 3.74e-03 | 2.63e-02 | 32 |
GO:0031100 | Colorectum | AD | animal organ regeneration | 26/3918 | 76/18723 | 4.94e-03 | 3.32e-02 | 26 |
GO:0002792 | Colorectum | AD | negative regulation of peptide secretion | 17/3918 | 44/18723 | 5.46e-03 | 3.56e-02 | 17 |
GO:0046676 | Colorectum | AD | negative regulation of insulin secretion | 15/3918 | 38/18723 | 7.01e-03 | 4.31e-02 | 15 |
GO:0106106 | Colorectum | AD | cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
GO:0120161 | Colorectum | AD | regulation of cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
GO:1990845 | Colorectum | AD | adaptive thermogenesis | 46/3918 | 157/18723 | 7.97e-03 | 4.73e-02 | 46 |
GO:0061179 | Colorectum | AD | negative regulation of insulin secretion involved in cellular response to glucose stimulus | 6/3918 | 10/18723 | 8.03e-03 | 4.73e-02 | 6 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
GO:19026001 | Colorectum | SER | proton transmembrane transport | 60/2897 | 157/18723 | 3.12e-12 | 7.08e-10 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UCP2 | SNV | Missense_Mutation | novel | c.22N>A | p.Asp8Asn | p.D8N | P55851 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-A2-A3XZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
UCP2 | SNV | Missense_Mutation | c.452G>C | p.Gly151Ala | p.G151A | P55851 | protein_coding | tolerated(0.57) | benign(0.006) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UCP2 | SNV | Missense_Mutation | c.94N>A | p.Phe32Ile | p.F32I | P55851 | protein_coding | tolerated(0.51) | possibly_damaging(0.643) | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
UCP2 | SNV | Missense_Mutation | c.52N>A | p.Leu18Ile | p.L18I | P55851 | protein_coding | tolerated(0.23) | benign(0.031) | TCGA-AQ-A7U7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | rituximab | CR | |
UCP2 | SNV | Missense_Mutation | c.488N>T | p.Tyr163Phe | p.Y163F | P55851 | protein_coding | deleterious(0) | possibly_damaging(0.738) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
UCP2 | deletion | Frame_Shift_Del | rs770840871 | c.143_144delAG | p.Gln48ArgfsTer25 | p.Q48Rfs*25 | P55851 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
UCP2 | SNV | Missense_Mutation | rs780835346 | c.292G>A | p.Gly98Ser | p.G98S | P55851 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UCP2 | SNV | Missense_Mutation | rs781271646 | c.154N>T | p.Arg52Cys | p.R52C | P55851 | protein_coding | deleterious(0.05) | benign(0.09) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
UCP2 | deletion | Frame_Shift_Del | c.32delN | p.Pro11LeufsTer5 | p.P11Lfs*5 | P55851 | protein_coding | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
UCP2 | SNV | Missense_Mutation | rs145061662 | c.263G>A | p.Arg88His | p.R88H | P55851 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | INTRALIPID | SOYBEAN OIL | 10868951 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | BRL49653 | 9299560 | ||
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | HEPARIN | HEPARIN | 10868951 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | ANTIOXIDANT | 15642337 | ||
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | TRIIODOTHYRONINE | LIOTHYRONINE SODIUM | 9428737,10444435 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | SALINE | SODIUM CHLORIDE | 10868951 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | CL-316,243 |
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