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Gene: TP53INP1 |
Gene summary for TP53INP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TP53INP1 | Gene ID | 94241 |
| Gene name | tumor protein p53 inducible nuclear protein 1 | |
| Gene Alias | SIP | |
| Cytomap | 8q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q96A56 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 94241 | TP53INP1 | LZE24T | Human | Esophagus | ESCC | 1.27e-21 | 6.26e-01 | 0.0596 |
| 94241 | TP53INP1 | P2T-E | Human | Esophagus | ESCC | 1.11e-08 | 1.35e-01 | 0.1177 |
| 94241 | TP53INP1 | P8T-E | Human | Esophagus | ESCC | 7.02e-11 | 1.46e-01 | 0.0889 |
| 94241 | TP53INP1 | P9T-E | Human | Esophagus | ESCC | 4.04e-06 | 9.56e-02 | 0.1131 |
| 94241 | TP53INP1 | P10T-E | Human | Esophagus | ESCC | 2.53e-16 | 3.30e-01 | 0.116 |
| 94241 | TP53INP1 | P12T-E | Human | Esophagus | ESCC | 5.98e-09 | 2.10e-01 | 0.1122 |
| 94241 | TP53INP1 | P15T-E | Human | Esophagus | ESCC | 4.78e-02 | 1.36e-01 | 0.1149 |
| 94241 | TP53INP1 | P16T-E | Human | Esophagus | ESCC | 2.52e-03 | 9.69e-02 | 0.1153 |
| 94241 | TP53INP1 | P20T-E | Human | Esophagus | ESCC | 4.49e-02 | 7.49e-02 | 0.1124 |
| 94241 | TP53INP1 | P21T-E | Human | Esophagus | ESCC | 7.13e-04 | 2.62e-02 | 0.1617 |
| 94241 | TP53INP1 | P22T-E | Human | Esophagus | ESCC | 3.09e-05 | 9.06e-02 | 0.1236 |
| 94241 | TP53INP1 | P23T-E | Human | Esophagus | ESCC | 2.02e-03 | 1.88e-01 | 0.108 |
| 94241 | TP53INP1 | P26T-E | Human | Esophagus | ESCC | 7.09e-04 | 4.77e-02 | 0.1276 |
| 94241 | TP53INP1 | P27T-E | Human | Esophagus | ESCC | 8.37e-08 | 2.14e-01 | 0.1055 |
| 94241 | TP53INP1 | P31T-E | Human | Esophagus | ESCC | 2.50e-09 | 2.06e-01 | 0.1251 |
| 94241 | TP53INP1 | P32T-E | Human | Esophagus | ESCC | 1.71e-02 | 1.75e-02 | 0.1666 |
| 94241 | TP53INP1 | P36T-E | Human | Esophagus | ESCC | 1.49e-05 | 1.65e-01 | 0.1187 |
| 94241 | TP53INP1 | P39T-E | Human | Esophagus | ESCC | 7.08e-04 | 8.66e-02 | 0.0894 |
| 94241 | TP53INP1 | P42T-E | Human | Esophagus | ESCC | 6.12e-03 | 1.10e-01 | 0.1175 |
| 94241 | TP53INP1 | P48T-E | Human | Esophagus | ESCC | 3.52e-05 | 7.99e-02 | 0.0959 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009266111 | Thyroid | PTC | response to temperature stimulus | 81/5968 | 178/18723 | 9.20e-05 | 7.63e-04 | 81 |
| GO:1990748112 | Thyroid | PTC | cellular detoxification | 56/5968 | 116/18723 | 1.63e-04 | 1.26e-03 | 56 |
| GO:0097237112 | Thyroid | PTC | cellular response to toxic substance | 59/5968 | 124/18723 | 1.83e-04 | 1.39e-03 | 59 |
| GO:004814516 | Thyroid | PTC | regulation of fibroblast proliferation | 41/5968 | 80/18723 | 2.43e-04 | 1.75e-03 | 41 |
| GO:0097305113 | Thyroid | PTC | response to alcohol | 107/5968 | 253/18723 | 2.92e-04 | 2.07e-03 | 107 |
| GO:004814416 | Thyroid | PTC | fibroblast proliferation | 41/5968 | 81/18723 | 3.41e-04 | 2.35e-03 | 41 |
| GO:0098869111 | Thyroid | PTC | cellular oxidant detoxification | 49/5968 | 101/18723 | 3.52e-04 | 2.41e-03 | 49 |
| GO:00094167 | Thyroid | PTC | response to light stimulus | 127/5968 | 320/18723 | 1.76e-03 | 9.58e-03 | 127 |
| GO:00714823 | Thyroid | PTC | cellular response to light stimulus | 53/5968 | 123/18723 | 5.73e-03 | 2.59e-02 | 53 |
| GO:0098754110 | Thyroid | PTC | detoxification | 63/5968 | 152/18723 | 7.92e-03 | 3.34e-02 | 63 |
| GO:0009896210 | Thyroid | ATC | positive regulation of catabolic process | 290/6293 | 492/18723 | 2.15e-31 | 1.94e-28 | 290 |
| GO:0031331210 | Thyroid | ATC | positive regulation of cellular catabolic process | 258/6293 | 427/18723 | 2.09e-30 | 1.65e-27 | 258 |
| GO:000697934 | Thyroid | ATC | response to oxidative stress | 246/6293 | 446/18723 | 2.98e-21 | 6.09e-19 | 246 |
| GO:001623623 | Thyroid | ATC | macroautophagy | 169/6293 | 291/18723 | 6.56e-18 | 7.69e-16 | 169 |
| GO:001050632 | Thyroid | ATC | regulation of autophagy | 180/6293 | 317/18723 | 1.34e-17 | 1.46e-15 | 180 |
| GO:006219734 | Thyroid | ATC | cellular response to chemical stress | 188/6293 | 337/18723 | 3.16e-17 | 3.07e-15 | 188 |
| GO:003459934 | Thyroid | ATC | cellular response to oxidative stress | 158/6293 | 288/18723 | 7.35e-14 | 3.94e-12 | 158 |
| GO:007121427 | Thyroid | ATC | cellular response to abiotic stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
| GO:010400427 | Thyroid | ATC | cellular response to environmental stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
| GO:000703322 | Thyroid | ATC | vacuole organization | 100/6293 | 180/18723 | 1.07e-09 | 2.71e-08 | 100 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TP53INP1 | SNV | Missense_Mutation | novel | c.379N>T | p.Pro127Ser | p.P127S | Q96A56 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| TP53INP1 | SNV | Missense_Mutation | c.649N>A | p.Asp217Asn | p.D217N | Q96A56 | protein_coding | tolerated(0.13) | possibly_damaging(0.536) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| TP53INP1 | SNV | Missense_Mutation | novel | c.82N>T | p.Asp28Tyr | p.D28Y | Q96A56 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TP53INP1 | insertion | Frame_Shift_Ins | novel | c.511_512insATCAGTG | p.Cys171TyrfsTer32 | p.C171Yfs*32 | Q96A56 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
| TP53INP1 | insertion | Frame_Shift_Ins | novel | c.509_510insACCAATTGATAACCAATCACATAGTT | p.His170GlnfsTer35 | p.H170Qfs*35 | Q96A56 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
| TP53INP1 | insertion | In_Frame_Ins | novel | c.139_140insTCTTCTTTCTCTTCATTTATACCC | p.Glu47delinsValPhePheLeuPheIleTyrThrGln | p.E47delinsVFFLFIYTQ | Q96A56 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| TP53INP1 | SNV | Missense_Mutation | c.136N>A | p.Glu46Lys | p.E46K | Q96A56 | protein_coding | tolerated(0.12) | benign(0.049) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| TP53INP1 | SNV | Missense_Mutation | novel | c.421N>T | p.Leu141Phe | p.L141F | Q96A56 | protein_coding | deleterious(0.02) | possibly_damaging(0.787) | TCGA-VS-A8QF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| TP53INP1 | deletion | Frame_Shift_Del | novel | c.26_29delTTGT | p.Phe9TrpfsTer28 | p.F9Wfs*28 | Q96A56 | protein_coding | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| TP53INP1 | SNV | Missense_Mutation | c.649N>A | p.Asp217Asn | p.D217N | Q96A56 | protein_coding | tolerated(0.13) | possibly_damaging(0.536) | TCGA-AA-3837-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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