Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/TIPARP_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TIPARP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TIPARP_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/TIPARP_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TIPARP_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/TIPARP_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TIPARP_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TIPARP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009896112 | Skin | SCCIS | positive regulation of catabolic process | 49/919 | 492/18723 | 2.10e-06 | 1.09e-04 | 49 |
GO:000165515 | Skin | SCCIS | urogenital system development | 30/919 | 338/18723 | 1.31e-03 | 1.52e-02 | 30 |
GO:00465453 | Skin | SCCIS | development of primary female sexual characteristics | 12/919 | 100/18723 | 3.59e-03 | 3.17e-02 | 12 |
GO:000182214 | Skin | SCCIS | kidney development | 25/919 | 293/18723 | 5.28e-03 | 4.21e-02 | 25 |
GO:00015706 | Skin | SCCIS | vasculogenesis | 10/919 | 80/18723 | 5.65e-03 | 4.44e-02 | 10 |
GO:000979113 | Skin | SCCIS | post-embryonic development | 10/919 | 80/18723 | 5.65e-03 | 4.44e-02 | 10 |
GO:004800814 | Skin | SCCIS | platelet-derived growth factor receptor signaling pathway | 8/919 | 56/18723 | 5.73e-03 | 4.46e-02 | 8 |
GO:004217629 | Skin | cSCC | regulation of protein catabolic process | 198/4864 | 391/18723 | 6.03e-26 | 1.89e-23 | 198 |
GO:000989628 | Skin | cSCC | positive regulation of catabolic process | 206/4864 | 492/18723 | 6.06e-15 | 4.64e-13 | 206 |
GO:004573229 | Skin | cSCC | positive regulation of protein catabolic process | 112/4864 | 231/18723 | 1.37e-13 | 8.40e-12 | 112 |
GO:006145825 | Skin | cSCC | reproductive system development | 149/4864 | 427/18723 | 2.30e-05 | 2.65e-04 | 149 |
GO:004860824 | Skin | cSCC | reproductive structure development | 148/4864 | 424/18723 | 2.40e-05 | 2.74e-04 | 148 |
GO:000979122 | Skin | cSCC | post-embryonic development | 32/4864 | 80/18723 | 4.18e-03 | 2.21e-02 | 32 |
GO:004800822 | Skin | cSCC | platelet-derived growth factor receptor signaling pathway | 24/4864 | 56/18723 | 4.44e-03 | 2.29e-02 | 24 |
GO:004217630 | Thyroid | HT | regulation of protein catabolic process | 70/1272 | 391/18723 | 5.96e-14 | 1.66e-11 | 70 |
GO:006053718 | Thyroid | HT | muscle tissue development | 62/1272 | 403/18723 | 1.10e-09 | 1.20e-07 | 62 |
GO:004573230 | Thyroid | HT | positive regulation of protein catabolic process | 40/1272 | 231/18723 | 3.91e-08 | 2.65e-06 | 40 |
GO:000989629 | Thyroid | HT | positive regulation of catabolic process | 63/1272 | 492/18723 | 8.49e-07 | 3.45e-05 | 63 |
GO:00015707 | Thyroid | HT | vasculogenesis | 15/1272 | 80/18723 | 2.81e-04 | 3.84e-03 | 15 |
GO:004860820 | Thyroid | HT | reproductive structure development | 46/1272 | 424/18723 | 1.14e-03 | 1.13e-02 | 46 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIPARP | SNV | Missense_Mutation | | c.443N>T | p.Ser148Ile | p.S148I | Q7Z3E1 | protein_coding | tolerated_low_confidence(0.09) | benign(0.058) | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TIPARP | SNV | Missense_Mutation | | c.1731N>C | p.Lys577Asn | p.K577N | Q7Z3E1 | protein_coding | tolerated(0.07) | possibly_damaging(0.874) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TIPARP | SNV | Missense_Mutation | | c.244G>A | p.Glu82Lys | p.E82K | Q7Z3E1 | protein_coding | tolerated_low_confidence(0.71) | benign(0.015) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
TIPARP | insertion | Frame_Shift_Ins | novel | c.559_560insGACTTTATTGGGCACCTAGGAT | p.Ile188LeufsTer24 | p.I188Lfs*24 | Q7Z3E1 | protein_coding | | | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TIPARP | insertion | Frame_Shift_Ins | novel | c.1587_1588insA | p.Leu530IlefsTer19 | p.L530Ifs*19 | Q7Z3E1 | protein_coding | | | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TIPARP | insertion | In_Frame_Ins | novel | c.1588_1589insCAGCACATTTGGAAGAAAACA | p.Leu530delinsSerAlaHisLeuGluGluAsnIle | p.L530delinsSAHLEENI | Q7Z3E1 | protein_coding | | | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TIPARP | deletion | Frame_Shift_Del | novel | c.260delN | p.Glu87AspfsTer3 | p.E87Dfs*3 | Q7Z3E1 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TIPARP | SNV | Missense_Mutation | rs745377501 | c.1097G>A | p.Arg366Gln | p.R366Q | Q7Z3E1 | protein_coding | tolerated(0.18) | benign(0.044) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TIPARP | SNV | Missense_Mutation | rs767797746 | c.1165N>G | p.Ile389Val | p.I389V | Q7Z3E1 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
TIPARP | SNV | Missense_Mutation | novel | c.1778N>T | p.Thr593Met | p.T593M | Q7Z3E1 | protein_coding | tolerated(0.06) | probably_damaging(0.986) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |