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Gene: SRP9 |
Gene summary for SRP9 |
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Gene information | Species | Human | Gene symbol | SRP9 | Gene ID | 6726 |
Gene name | signal recognition particle 9 | |
Gene Alias | ALURBP | |
Cytomap | 1q42.12 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A0A024R3P3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6726 | SRP9 | GSM4909281 | Human | Breast | IDC | 9.28e-15 | 4.69e-01 | 0.21 |
6726 | SRP9 | GSM4909285 | Human | Breast | IDC | 2.61e-03 | 3.76e-01 | 0.21 |
6726 | SRP9 | GSM4909286 | Human | Breast | IDC | 1.38e-04 | 2.32e-01 | 0.1081 |
6726 | SRP9 | GSM4909287 | Human | Breast | IDC | 3.65e-02 | 1.60e-01 | 0.2057 |
6726 | SRP9 | GSM4909288 | Human | Breast | IDC | 3.61e-05 | 1.01e-01 | 0.0988 |
6726 | SRP9 | GSM4909289 | Human | Breast | IDC | 1.95e-11 | 6.58e-01 | 0.1064 |
6726 | SRP9 | GSM4909290 | Human | Breast | IDC | 3.35e-18 | 5.71e-01 | 0.2096 |
6726 | SRP9 | GSM4909293 | Human | Breast | IDC | 1.88e-18 | 5.36e-01 | 0.1581 |
6726 | SRP9 | GSM4909294 | Human | Breast | IDC | 2.66e-21 | 4.31e-01 | 0.2022 |
6726 | SRP9 | GSM4909296 | Human | Breast | IDC | 2.11e-19 | -4.44e-01 | 0.1524 |
6726 | SRP9 | GSM4909297 | Human | Breast | IDC | 1.11e-22 | 5.12e-03 | 0.1517 |
6726 | SRP9 | GSM4909298 | Human | Breast | IDC | 4.08e-26 | 6.04e-01 | 0.1551 |
6726 | SRP9 | GSM4909301 | Human | Breast | IDC | 4.20e-10 | -4.06e-01 | 0.1577 |
6726 | SRP9 | GSM4909305 | Human | Breast | IDC | 2.74e-02 | 3.01e-01 | 0.0436 |
6726 | SRP9 | GSM4909306 | Human | Breast | IDC | 5.57e-30 | 6.05e-01 | 0.1564 |
6726 | SRP9 | GSM4909307 | Human | Breast | IDC | 3.78e-13 | 4.21e-01 | 0.1569 |
6726 | SRP9 | GSM4909308 | Human | Breast | IDC | 2.69e-72 | 8.86e-01 | 0.158 |
6726 | SRP9 | GSM4909311 | Human | Breast | IDC | 2.36e-43 | -4.89e-01 | 0.1534 |
6726 | SRP9 | GSM4909312 | Human | Breast | IDC | 8.01e-23 | 2.68e-01 | 0.1552 |
6726 | SRP9 | GSM4909313 | Human | Breast | IDC | 1.20e-05 | 1.47e-01 | 0.0391 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00171488 | Thyroid | HT | negative regulation of translation | 32/1272 | 245/18723 | 2.85e-04 | 3.86e-03 | 32 |
GO:00066137 | Thyroid | HT | cotranslational protein targeting to membrane | 8/1272 | 31/18723 | 8.56e-04 | 9.17e-03 | 8 |
GO:000641424 | Thyroid | HT | translational elongation | 11/1272 | 55/18723 | 1.02e-03 | 1.04e-02 | 11 |
GO:00066143 | Thyroid | HT | SRP-dependent cotranslational protein targeting to membrane | 6/1272 | 26/18723 | 6.89e-03 | 4.20e-02 | 6 |
GO:0072594112 | Thyroid | PTC | establishment of protein localization to organelle | 244/5968 | 422/18723 | 1.18e-28 | 4.97e-26 | 244 |
GO:0006605113 | Thyroid | PTC | protein targeting | 180/5968 | 314/18723 | 6.81e-21 | 1.19e-18 | 180 |
GO:0090150112 | Thyroid | PTC | establishment of protein localization to membrane | 149/5968 | 260/18723 | 1.64e-17 | 1.59e-15 | 149 |
GO:0006417113 | Thyroid | PTC | regulation of translation | 236/5968 | 468/18723 | 2.70e-17 | 2.52e-15 | 236 |
GO:0070972111 | Thyroid | PTC | protein localization to endoplasmic reticulum | 51/5968 | 74/18723 | 6.57e-11 | 2.30e-09 | 51 |
GO:007259918 | Thyroid | PTC | establishment of protein localization to endoplasmic reticulum | 31/5968 | 46/18723 | 8.06e-07 | 1.24e-05 | 31 |
GO:004504716 | Thyroid | PTC | protein targeting to ER | 28/5968 | 42/18723 | 3.83e-06 | 4.80e-05 | 28 |
GO:003424916 | Thyroid | PTC | negative regulation of cellular amide metabolic process | 122/5968 | 273/18723 | 5.50e-06 | 6.64e-05 | 122 |
GO:00066126 | Thyroid | PTC | protein targeting to membrane | 64/5968 | 131/18723 | 3.67e-05 | 3.41e-04 | 64 |
GO:001714815 | Thyroid | PTC | negative regulation of translation | 108/5968 | 245/18723 | 3.75e-05 | 3.48e-04 | 108 |
GO:000661313 | Thyroid | PTC | cotranslational protein targeting to membrane | 19/5968 | 31/18723 | 7.02e-04 | 4.39e-03 | 19 |
GO:007259429 | Thyroid | ATC | establishment of protein localization to organelle | 247/6293 | 422/18723 | 2.88e-26 | 1.40e-23 | 247 |
GO:000660533 | Thyroid | ATC | protein targeting | 180/6293 | 314/18723 | 3.54e-18 | 4.39e-16 | 180 |
GO:009015031 | Thyroid | ATC | establishment of protein localization to membrane | 150/6293 | 260/18723 | 1.05e-15 | 7.96e-14 | 150 |
GO:000641735 | Thyroid | ATC | regulation of translation | 236/6293 | 468/18723 | 2.39e-14 | 1.34e-12 | 236 |
GO:007097232 | Thyroid | ATC | protein localization to endoplasmic reticulum | 53/6293 | 74/18723 | 2.52e-11 | 8.69e-10 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030602 | Colorectum | MSS | Protein export | 15/1875 | 23/8465 | 1.13e-05 | 1.26e-04 | 7.71e-05 | 15 |
hsa030603 | Colorectum | MSS | Protein export | 15/1875 | 23/8465 | 1.13e-05 | 1.26e-04 | 7.71e-05 | 15 |
hsa0306023 | Endometrium | EEC | Protein export | 11/1237 | 23/8465 | 1.54e-04 | 1.41e-03 | 1.05e-03 | 11 |
hsa0306033 | Endometrium | EEC | Protein export | 11/1237 | 23/8465 | 1.54e-04 | 1.41e-03 | 1.05e-03 | 11 |
hsa0306026 | Esophagus | ESCC | Protein export | 22/4205 | 23/8465 | 2.43e-06 | 1.43e-05 | 7.32e-06 | 22 |
hsa0306036 | Esophagus | ESCC | Protein export | 22/4205 | 23/8465 | 2.43e-06 | 1.43e-05 | 7.32e-06 | 22 |
hsa030608 | Liver | Cirrhotic | Protein export | 20/2530 | 23/8465 | 2.00e-08 | 3.51e-07 | 2.17e-07 | 20 |
hsa0306011 | Liver | Cirrhotic | Protein export | 20/2530 | 23/8465 | 2.00e-08 | 3.51e-07 | 2.17e-07 | 20 |
hsa0306021 | Liver | HCC | Protein export | 21/4020 | 23/8465 | 1.20e-05 | 8.53e-05 | 4.74e-05 | 21 |
hsa0306031 | Liver | HCC | Protein export | 21/4020 | 23/8465 | 1.20e-05 | 8.53e-05 | 4.74e-05 | 21 |
hsa0306018 | Oral cavity | OSCC | Protein export | 21/3704 | 23/8465 | 2.42e-06 | 1.27e-05 | 6.45e-06 | 21 |
hsa0306019 | Oral cavity | OSCC | Protein export | 21/3704 | 23/8465 | 2.42e-06 | 1.27e-05 | 6.45e-06 | 21 |
hsa0306025 | Oral cavity | LP | Protein export | 21/2418 | 23/8465 | 4.72e-10 | 8.28e-09 | 5.34e-09 | 21 |
hsa0306035 | Oral cavity | LP | Protein export | 21/2418 | 23/8465 | 4.72e-10 | 8.28e-09 | 5.34e-09 | 21 |
hsa0306016 | Prostate | BPH | Protein export | 18/1718 | 23/8465 | 3.72e-09 | 5.11e-08 | 3.16e-08 | 18 |
hsa0306017 | Prostate | BPH | Protein export | 18/1718 | 23/8465 | 3.72e-09 | 5.11e-08 | 3.16e-08 | 18 |
hsa0306024 | Prostate | Tumor | Protein export | 18/1791 | 23/8465 | 7.50e-09 | 1.03e-07 | 6.42e-08 | 18 |
hsa0306034 | Prostate | Tumor | Protein export | 18/1791 | 23/8465 | 7.50e-09 | 1.03e-07 | 6.42e-08 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRP9 | SNV | Missense_Mutation | novel | c.166N>A | p.Ala56Thr | p.A56T | P49458 | protein_coding | tolerated(0.12) | possibly_damaging(0.573) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SRP9 | SNV | Missense_Mutation | novel | c.133N>T | p.Asp45Tyr | p.D45Y | P49458 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SRP9 | SNV | Missense_Mutation | c.181A>G | p.Lys61Glu | p.K61E | P49458 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-95-7947-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SRP9 | SNV | Missense_Mutation | c.77G>A | p.Arg26His | p.R26H | P49458 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
SRP9 | SNV | Missense_Mutation | novel | c.220N>A | p.Val74Ile | p.V74I | P49458 | protein_coding | tolerated(0.08) | benign(0.077) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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