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Gene: SIPA1 |
Gene summary for SIPA1 |
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Gene information | Species | Human | Gene symbol | SIPA1 | Gene ID | 6494 |
Gene name | signal-induced proliferation-associated 1 | |
Gene Alias | SPA1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001101 | UniProtAcc | Q96FS4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6494 | SIPA1 | LZE5T | Human | Esophagus | ESCC | 1.02e-05 | 3.65e-01 | 0.0514 |
6494 | SIPA1 | LZE20T | Human | Esophagus | ESCC | 1.94e-21 | 7.57e-01 | 0.0662 |
6494 | SIPA1 | LZE22T | Human | Esophagus | ESCC | 3.76e-04 | 4.15e-01 | 0.068 |
6494 | SIPA1 | LZE24T | Human | Esophagus | ESCC | 3.32e-33 | 7.78e-01 | 0.0596 |
6494 | SIPA1 | P1T-E | Human | Esophagus | ESCC | 8.04e-17 | 6.33e-01 | 0.0875 |
6494 | SIPA1 | P2T-E | Human | Esophagus | ESCC | 8.98e-11 | 1.34e-01 | 0.1177 |
6494 | SIPA1 | P4T-E | Human | Esophagus | ESCC | 3.70e-17 | 4.04e-01 | 0.1323 |
6494 | SIPA1 | P5T-E | Human | Esophagus | ESCC | 5.61e-14 | 2.49e-01 | 0.1327 |
6494 | SIPA1 | P8T-E | Human | Esophagus | ESCC | 3.34e-50 | 1.04e+00 | 0.0889 |
6494 | SIPA1 | P9T-E | Human | Esophagus | ESCC | 5.26e-04 | 1.25e-01 | 0.1131 |
6494 | SIPA1 | P10T-E | Human | Esophagus | ESCC | 6.95e-03 | 6.97e-02 | 0.116 |
6494 | SIPA1 | P11T-E | Human | Esophagus | ESCC | 3.49e-06 | 2.16e-01 | 0.1426 |
6494 | SIPA1 | P12T-E | Human | Esophagus | ESCC | 1.74e-03 | 1.25e-01 | 0.1122 |
6494 | SIPA1 | P15T-E | Human | Esophagus | ESCC | 4.50e-21 | 4.31e-01 | 0.1149 |
6494 | SIPA1 | P16T-E | Human | Esophagus | ESCC | 8.64e-19 | 3.91e-01 | 0.1153 |
6494 | SIPA1 | P17T-E | Human | Esophagus | ESCC | 4.36e-13 | 5.10e-01 | 0.1278 |
6494 | SIPA1 | P19T-E | Human | Esophagus | ESCC | 3.01e-06 | 4.41e-01 | 0.1662 |
6494 | SIPA1 | P20T-E | Human | Esophagus | ESCC | 6.05e-24 | 4.92e-01 | 0.1124 |
6494 | SIPA1 | P21T-E | Human | Esophagus | ESCC | 2.67e-07 | 2.29e-01 | 0.1617 |
6494 | SIPA1 | P23T-E | Human | Esophagus | ESCC | 4.43e-31 | 7.70e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00435474 | Liver | NAFLD | positive regulation of GTPase activity | 45/1882 | 255/18723 | 1.30e-04 | 2.47e-03 | 45 |
GO:00163585 | Liver | NAFLD | dendrite development | 43/1882 | 243/18723 | 1.70e-04 | 3.07e-03 | 43 |
GO:00488133 | Liver | NAFLD | dendrite morphogenesis | 29/1882 | 146/18723 | 2.63e-04 | 4.26e-03 | 29 |
GO:00609963 | Liver | NAFLD | dendritic spine development | 21/1882 | 99/18723 | 7.26e-04 | 9.27e-03 | 21 |
GO:00109755 | Liver | NAFLD | regulation of neuron projection development | 64/1882 | 445/18723 | 2.12e-03 | 2.08e-02 | 64 |
GO:00906301 | Liver | NAFLD | activation of GTPase activity | 22/1882 | 115/18723 | 2.28e-03 | 2.19e-02 | 22 |
GO:00970615 | Liver | NAFLD | dendritic spine organization | 17/1882 | 84/18723 | 3.76e-03 | 3.21e-02 | 17 |
GO:01060275 | Liver | NAFLD | neuron projection organization | 18/1882 | 93/18723 | 4.80e-03 | 3.81e-02 | 18 |
GO:00615645 | Liver | NAFLD | axon development | 64/1882 | 467/18723 | 6.48e-03 | 4.69e-02 | 64 |
GO:00609973 | Liver | NAFLD | dendritic spine morphogenesis | 13/1882 | 61/18723 | 6.77e-03 | 4.79e-02 | 13 |
GO:00074095 | Liver | NAFLD | axonogenesis | 58/1882 | 418/18723 | 7.16e-03 | 4.96e-02 | 58 |
GO:00315326 | Liver | Cirrhotic | actin cytoskeleton reorganization | 42/4634 | 107/18723 | 6.28e-04 | 4.81e-03 | 42 |
GO:007149622 | Liver | HCC | cellular response to external stimulus | 191/7958 | 320/18723 | 3.40e-10 | 1.13e-08 | 191 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:003166812 | Liver | HCC | cellular response to extracellular stimulus | 149/7958 | 246/18723 | 7.35e-09 | 1.86e-07 | 149 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:0045786 | Liver | HCC | negative regulation of cell cycle | 204/7958 | 385/18723 | 1.84e-05 | 1.99e-04 | 204 |
GO:000110111 | Liver | HCC | response to acid chemical | 79/7958 | 135/18723 | 1.24e-04 | 1.03e-03 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0467042 | Liver | HCC | Leukocyte transendothelial migration | 68/4020 | 114/8465 | 5.79e-03 | 1.64e-02 | 9.15e-03 | 68 |
hsa0467052 | Liver | HCC | Leukocyte transendothelial migration | 68/4020 | 114/8465 | 5.79e-03 | 1.64e-02 | 9.15e-03 | 68 |
hsa0467030 | Oral cavity | OSCC | Leukocyte transendothelial migration | 63/3704 | 114/8465 | 8.46e-03 | 1.96e-02 | 9.95e-03 | 63 |
hsa0401518 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
hsa04670113 | Oral cavity | OSCC | Leukocyte transendothelial migration | 63/3704 | 114/8465 | 8.46e-03 | 1.96e-02 | 9.95e-03 | 63 |
hsa0401519 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIPA1 | SNV | Missense_Mutation | rs747257834 | c.2644N>A | p.Pro882Thr | p.P882T | Q96FS4 | protein_coding | tolerated(0.07) | benign(0.025) | TCGA-AC-A5XU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
SIPA1 | SNV | Missense_Mutation | c.724N>A | p.Ala242Thr | p.A242T | Q96FS4 | protein_coding | deleterious(0) | possibly_damaging(0.679) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIPA1 | SNV | Missense_Mutation | c.3118N>C | p.Asp1040His | p.D1040H | Q96FS4 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.995) | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD | |
SIPA1 | SNV | Missense_Mutation | c.3120N>A | p.Asp1040Glu | p.D1040E | Q96FS4 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.935) | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD | |
SIPA1 | SNV | Missense_Mutation | novel | c.1247N>G | p.Pro416Arg | p.P416R | Q96FS4 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SIPA1 | insertion | In_Frame_Ins | novel | c.726_727insCCC | p.Ala242_Val243insPro | p.A242_V243insP | Q96FS4 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SIPA1 | SNV | Missense_Mutation | c.2530N>G | p.Leu844Val | p.L844V | Q96FS4 | protein_coding | tolerated(0.15) | benign(0.025) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
SIPA1 | SNV | Missense_Mutation | c.803C>T | p.Thr268Met | p.T268M | Q96FS4 | protein_coding | deleterious(0) | possibly_damaging(0.799) | TCGA-EA-A3HQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SIPA1 | SNV | Missense_Mutation | c.778N>G | p.Ser260Gly | p.S260G | Q96FS4 | protein_coding | deleterious(0.02) | benign(0.281) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIPA1 | SNV | Missense_Mutation | novel | c.2713N>T | p.Arg905Cys | p.R905C | Q96FS4 | protein_coding | deleterious(0) | possibly_damaging(0.799) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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