Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SH3RF1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SH3RF1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SH3RF1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/SH3RF1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SH3RF1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SH3RF1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/SH3RF1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SH3RF1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SH3RF1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SH3RF1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004328117 | Endometrium | EEC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 46/2168 | 209/18723 | 1.20e-05 | 2.46e-04 | 46 |
GO:005134615 | Endometrium | EEC | negative regulation of hydrolase activity | 72/2168 | 379/18723 | 1.46e-05 | 2.87e-04 | 72 |
GO:200011617 | Endometrium | EEC | regulation of cysteine-type endopeptidase activity | 49/2168 | 235/18723 | 2.91e-05 | 5.08e-04 | 49 |
GO:004211014 | Endometrium | EEC | T cell activation | 85/2168 | 487/18723 | 6.81e-05 | 1.01e-03 | 85 |
GO:200123717 | Endometrium | EEC | negative regulation of extrinsic apoptotic signaling pathway | 25/2168 | 97/18723 | 8.28e-05 | 1.19e-03 | 25 |
GO:190370615 | Endometrium | EEC | regulation of hemopoiesis | 67/2168 | 367/18723 | 1.01e-04 | 1.40e-03 | 67 |
GO:005086313 | Endometrium | EEC | regulation of T cell activation | 60/2168 | 329/18723 | 2.33e-04 | 2.75e-03 | 60 |
GO:00017641 | Endometrium | EEC | neuron migration | 33/2168 | 156/18723 | 4.17e-04 | 4.38e-03 | 33 |
GO:001046615 | Endometrium | EEC | negative regulation of peptidase activity | 49/2168 | 262/18723 | 4.64e-04 | 4.79e-03 | 49 |
GO:001095114 | Endometrium | EEC | negative regulation of endopeptidase activity | 47/2168 | 252/18723 | 6.37e-04 | 6.25e-03 | 47 |
GO:003287411 | Endometrium | EEC | positive regulation of stress-activated MAPK cascade | 27/2168 | 126/18723 | 1.09e-03 | 9.43e-03 | 27 |
GO:004315410 | Endometrium | EEC | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 19/2168 | 78/18723 | 1.19e-03 | 1.00e-02 | 19 |
GO:007030411 | Endometrium | EEC | positive regulation of stress-activated protein kinase signaling cascade | 27/2168 | 128/18723 | 1.39e-03 | 1.14e-02 | 27 |
GO:000725414 | Endometrium | EEC | JNK cascade | 33/2168 | 167/18723 | 1.44e-03 | 1.17e-02 | 33 |
GO:200011715 | Endometrium | EEC | negative regulation of cysteine-type endopeptidase activity | 20/2168 | 86/18723 | 1.65e-03 | 1.29e-02 | 20 |
GO:004209814 | Endometrium | EEC | T cell proliferation | 37/2168 | 199/18723 | 2.40e-03 | 1.77e-02 | 37 |
GO:00463286 | Endometrium | EEC | regulation of JNK cascade | 27/2168 | 133/18723 | 2.50e-03 | 1.83e-02 | 27 |
GO:004212913 | Endometrium | EEC | regulation of T cell proliferation | 32/2168 | 171/18723 | 4.09e-03 | 2.69e-02 | 32 |
GO:19021057 | Endometrium | EEC | regulation of leukocyte differentiation | 47/2168 | 279/18723 | 5.30e-03 | 3.29e-02 | 47 |
GO:007066313 | Endometrium | EEC | regulation of leukocyte proliferation | 42/2168 | 245/18723 | 5.94e-03 | 3.54e-02 | 42 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SH3RF1 | SNV | Missense_Mutation | novel | c.2350N>T | p.Ala784Ser | p.A784S | Q7Z6J0 | protein_coding | tolerated(1) | benign(0) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD |
SH3RF1 | SNV | Missense_Mutation | novel | c.2125N>C | p.Asp709His | p.D709H | Q7Z6J0 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SH3RF1 | SNV | Missense_Mutation | novel | c.1762N>G | p.Asn588Asp | p.N588D | Q7Z6J0 | protein_coding | tolerated(0.06) | benign(0.112) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
SH3RF1 | SNV | Missense_Mutation | | c.1033G>A | p.Glu345Lys | p.E345K | Q7Z6J0 | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-AR-A250-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
SH3RF1 | SNV | Missense_Mutation | novel | c.1129N>A | p.Gly377Ser | p.G377S | Q7Z6J0 | protein_coding | tolerated(0.11) | possibly_damaging(0.661) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
SH3RF1 | insertion | Frame_Shift_Ins | novel | c.411_412insGCCCACCTGGTGTCCTTTCCAAC | p.Cys138AlafsTer80 | p.C138Afs*80 | Q7Z6J0 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
SH3RF1 | insertion | Nonsense_Mutation | novel | c.2194_2195insGTTCCAGGAAAAAACTAAAAAATGAACAATAG | p.Pro732ArgfsTer11 | p.P732Rfs*11 | Q7Z6J0 | protein_coding | | | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
SH3RF1 | SNV | Missense_Mutation | novel | c.1726N>T | p.His576Tyr | p.H576Y | Q7Z6J0 | protein_coding | deleterious(0.01) | benign(0.172) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SH3RF1 | SNV | Missense_Mutation | novel | c.578C>T | p.Pro193Leu | p.P193L | Q7Z6J0 | protein_coding | deleterious(0) | benign(0.158) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SH3RF1 | SNV | Missense_Mutation | rs755524119 | c.1569N>C | p.Gln523His | p.Q523H | Q7Z6J0 | protein_coding | tolerated(0.15) | possibly_damaging(0.556) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |