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Gene: SEMA3E |
Gene summary for SEMA3E |
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Gene information | Species | Human | Gene symbol | SEMA3E | Gene ID | 9723 |
Gene name | semaphorin 3E | |
Gene Alias | M-SEMAH | |
Cytomap | 7q21.11 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O15041 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9723 | SEMA3E | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.36e-15 | 3.40e-01 | 0.0155 |
9723 | SEMA3E | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.63e-06 | 2.39e-01 | -0.1808 |
9723 | SEMA3E | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.75e-11 | 4.41e-01 | -0.0811 |
9723 | SEMA3E | HTA11_78_2000001011 | Human | Colorectum | AD | 2.36e-05 | 3.48e-01 | -0.1088 |
9723 | SEMA3E | HTA11_347_2000001011 | Human | Colorectum | AD | 3.85e-09 | 2.42e-01 | -0.1954 |
9723 | SEMA3E | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.60e-03 | 2.35e-01 | -0.1207 |
9723 | SEMA3E | HTA11_696_2000001011 | Human | Colorectum | AD | 1.15e-09 | 2.51e-01 | -0.1464 |
9723 | SEMA3E | HTA11_866_2000001011 | Human | Colorectum | AD | 1.17e-05 | 1.86e-01 | -0.1001 |
9723 | SEMA3E | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.76e-07 | 2.45e-01 | -0.059 |
9723 | SEMA3E | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.29e-03 | 3.68e-01 | -0.1706 |
9723 | SEMA3E | HTA11_546_2000001011 | Human | Colorectum | AD | 1.96e-03 | 3.08e-01 | -0.0842 |
9723 | SEMA3E | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.83e-10 | 4.72e-01 | -0.0179 |
9723 | SEMA3E | HTA11_866_3004761011 | Human | Colorectum | AD | 6.95e-06 | 2.83e-01 | 0.096 |
9723 | SEMA3E | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.30e-05 | 1.95e-01 | 0.0674 |
9723 | SEMA3E | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.60e-03 | 2.43e-01 | 0.0588 |
9723 | SEMA3E | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.48e-21 | 5.46e-01 | 0.294 |
9723 | SEMA3E | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.29e-02 | 4.75e-01 | 0.3487 |
9723 | SEMA3E | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.31e-04 | 2.57e-01 | 0.281 |
9723 | SEMA3E | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.18e-14 | 4.71e-01 | 0.3859 |
9723 | SEMA3E | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.49e-65 | 1.22e+00 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604911 | Liver | Cirrhotic | cell growth | 160/4634 | 482/18723 | 1.50e-05 | 2.07e-04 | 160 |
GO:000716011 | Liver | Cirrhotic | cell-matrix adhesion | 85/4634 | 233/18723 | 4.06e-05 | 4.83e-04 | 85 |
GO:000155811 | Liver | Cirrhotic | regulation of cell growth | 132/4634 | 414/18723 | 5.53e-04 | 4.36e-03 | 132 |
GO:00315326 | Liver | Cirrhotic | actin cytoskeleton reorganization | 42/4634 | 107/18723 | 6.28e-04 | 4.81e-03 | 42 |
GO:000166712 | Liver | Cirrhotic | ameboidal-type cell migration | 145/4634 | 475/18723 | 2.23e-03 | 1.36e-02 | 145 |
GO:00071624 | Liver | Cirrhotic | negative regulation of cell adhesion | 93/4634 | 303/18723 | 1.06e-02 | 4.66e-02 | 93 |
GO:004886311 | Liver | Cirrhotic | stem cell differentiation | 66/4634 | 206/18723 | 1.06e-02 | 4.68e-02 | 66 |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:003297022 | Liver | HCC | regulation of actin filament-based process | 222/7958 | 397/18723 | 3.81e-08 | 8.30e-07 | 222 |
GO:003295622 | Liver | HCC | regulation of actin cytoskeleton organization | 202/7958 | 358/18723 | 6.18e-08 | 1.29e-06 | 202 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:000836022 | Liver | HCC | regulation of cell shape | 92/7958 | 154/18723 | 1.15e-05 | 1.31e-04 | 92 |
GO:001081022 | Liver | HCC | regulation of cell-substrate adhesion | 123/7958 | 221/18723 | 5.15e-05 | 4.90e-04 | 123 |
GO:003158922 | Liver | HCC | cell-substrate adhesion | 188/7958 | 363/18723 | 2.00e-04 | 1.55e-03 | 188 |
GO:000195221 | Liver | HCC | regulation of cell-matrix adhesion | 74/7958 | 128/18723 | 3.34e-04 | 2.34e-03 | 74 |
GO:006056011 | Liver | HCC | developmental growth involved in morphogenesis | 124/7958 | 234/18723 | 7.37e-04 | 4.47e-03 | 124 |
GO:000716021 | Liver | HCC | cell-matrix adhesion | 123/7958 | 233/18723 | 9.34e-04 | 5.47e-03 | 123 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04360 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043601 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa0436010 | Endometrium | AEH | Axon guidance | 39/1197 | 182/8465 | 4.47e-03 | 2.46e-02 | 1.80e-02 | 39 |
hsa0436013 | Endometrium | AEH | Axon guidance | 39/1197 | 182/8465 | 4.47e-03 | 2.46e-02 | 1.80e-02 | 39 |
hsa0436022 | Endometrium | EEC | Axon guidance | 39/1237 | 182/8465 | 7.78e-03 | 3.66e-02 | 2.73e-02 | 39 |
hsa0436032 | Endometrium | EEC | Axon guidance | 39/1237 | 182/8465 | 7.78e-03 | 3.66e-02 | 2.73e-02 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
SEMA3E | PLXND1 | SEMA3E_PLXND1 | SEMA3 | CRC | MSI-H |
SEMA3E | PLXND1 | SEMA3E_PLXND1 | SEMA3 | CRC | MSS |
SEMA3E | PLXND1 | SEMA3E_PLXND1 | SEMA3 | Esophagus | ESCC |
SEMA3E | PLXND1 | SEMA3E_PLXND1 | SEMA3 | Liver | Healthy |
SEMA3E | PLXND1 | SEMA3E_PLXND1 | SEMA3 | Liver | Precancer |
SEMA3E | PLXND1 | SEMA3E_PLXND1 | SEMA3 | Prostate | BPH |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEMA3E | SNV | Missense_Mutation | novel | c.109N>T | p.His37Tyr | p.H37Y | O15041 | protein_coding | tolerated(1) | benign(0) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
SEMA3E | SNV | Missense_Mutation | rs121918341 | c.2108N>T | p.Ser703Leu | p.S703L | O15041 | protein_coding | tolerated(0.26) | benign(0.001) | TCGA-BH-A0RX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
SEMA3E | SNV | Missense_Mutation | novel | c.637N>T | p.Arg213Cys | p.R213C | O15041 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
SEMA3E | insertion | Frame_Shift_Ins | novel | c.338_339insAATGCAGGAGGAGGGAAGATTTCAAACT | p.Glu114MetfsTer10 | p.E114Mfs*10 | O15041 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SEMA3E | insertion | Frame_Shift_Ins | novel | c.337-1_337insCA | p.Gly113GlnfsTer20 | p.G113Qfs*20 | O15041 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SEMA3E | insertion | Nonsense_Mutation | novel | c.748_749insTTTAA | p.Glu250ValfsTer2 | p.E250Vfs*2 | O15041 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
SEMA3E | insertion | Frame_Shift_Ins | novel | c.747_748insCAGTA | p.Glu250GlnfsTer2 | p.E250Qfs*2 | O15041 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
SEMA3E | deletion | Frame_Shift_Del | novel | c.2307delN | p.Arg770GlyfsTer16 | p.R770Gfs*16 | O15041 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SEMA3E | SNV | Missense_Mutation | c.1637G>A | p.Arg546Gln | p.R546Q | O15041 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SEMA3E | SNV | Missense_Mutation | novel | c.1684G>A | p.Asp562Asn | p.D562N | O15041 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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