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Gene: RPL26 |
Gene summary for RPL26 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RPL26 | Gene ID | 6154 |
Gene name | ribosomal protein L26 | |
Gene Alias | DBA11 | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | P61254 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6154 | RPL26 | GSM4909281 | Human | Breast | IDC | 1.10e-39 | -2.65e-01 | 0.21 |
6154 | RPL26 | GSM4909282 | Human | Breast | IDC | 1.26e-105 | -5.75e-01 | -0.0288 |
6154 | RPL26 | GSM4909285 | Human | Breast | IDC | 2.01e-33 | -2.30e-01 | 0.21 |
6154 | RPL26 | GSM4909286 | Human | Breast | IDC | 6.74e-38 | -2.42e-01 | 0.1081 |
6154 | RPL26 | GSM4909287 | Human | Breast | IDC | 1.06e-87 | -6.99e-01 | 0.2057 |
6154 | RPL26 | GSM4909289 | Human | Breast | IDC | 9.69e-09 | -3.05e-01 | 0.1064 |
6154 | RPL26 | GSM4909290 | Human | Breast | IDC | 7.34e-75 | -5.17e-01 | 0.2096 |
6154 | RPL26 | GSM4909291 | Human | Breast | IDC | 3.55e-19 | -2.21e-01 | 0.1753 |
6154 | RPL26 | GSM4909292 | Human | Breast | IDC | 8.47e-23 | -5.89e-01 | 0.1236 |
6154 | RPL26 | GSM4909293 | Human | Breast | IDC | 9.12e-51 | -2.79e-01 | 0.1581 |
6154 | RPL26 | GSM4909294 | Human | Breast | IDC | 2.81e-33 | -3.54e-01 | 0.2022 |
6154 | RPL26 | GSM4909295 | Human | Breast | IDC | 3.59e-07 | -2.25e-01 | 0.0898 |
6154 | RPL26 | GSM4909296 | Human | Breast | IDC | 1.57e-06 | -1.35e-01 | 0.1524 |
6154 | RPL26 | GSM4909304 | Human | Breast | IDC | 7.89e-31 | -1.96e-01 | 0.1636 |
6154 | RPL26 | GSM4909307 | Human | Breast | IDC | 1.15e-41 | -2.77e-01 | 0.1569 |
6154 | RPL26 | GSM4909308 | Human | Breast | IDC | 1.48e-45 | -2.99e-01 | 0.158 |
6154 | RPL26 | GSM4909309 | Human | Breast | IDC | 1.53e-02 | -1.47e-01 | 0.0483 |
6154 | RPL26 | GSM4909311 | Human | Breast | IDC | 1.04e-08 | -1.92e-01 | 0.1534 |
6154 | RPL26 | GSM4909312 | Human | Breast | IDC | 1.41e-31 | -2.66e-01 | 0.1552 |
6154 | RPL26 | GSM4909315 | Human | Breast | IDC | 4.20e-44 | -3.82e-01 | 0.21 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190225315 | Cervix | HSIL_HPV | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 8/737 | 29/18723 | 1.14e-05 | 3.77e-04 | 8 |
GO:000863014 | Cervix | HSIL_HPV | intrinsic apoptotic signaling pathway in response to DNA damage | 14/737 | 99/18723 | 3.25e-05 | 9.15e-04 | 14 |
GO:004277114 | Cervix | HSIL_HPV | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 8/737 | 43/18723 | 2.37e-04 | 4.15e-03 | 8 |
GO:190216514 | Cervix | HSIL_HPV | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 5/737 | 16/18723 | 2.83e-04 | 4.69e-03 | 5 |
GO:190222913 | Cervix | HSIL_HPV | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 7/737 | 36/18723 | 4.38e-04 | 6.51e-03 | 7 |
GO:000641715 | Cervix | HSIL_HPV | regulation of translation | 34/737 | 468/18723 | 4.66e-04 | 6.83e-03 | 34 |
GO:001033212 | Cervix | HSIL_HPV | response to gamma radiation | 8/737 | 56/18723 | 1.48e-03 | 1.65e-02 | 8 |
GO:00435165 | Cervix | HSIL_HPV | regulation of DNA damage response, signal transduction by p53 class mediator | 6/737 | 34/18723 | 1.91e-03 | 2.01e-02 | 6 |
GO:007147914 | Cervix | HSIL_HPV | cellular response to ionizing radiation | 9/737 | 72/18723 | 2.00e-03 | 2.08e-02 | 9 |
GO:001021214 | Cervix | HSIL_HPV | response to ionizing radiation | 14/737 | 148/18723 | 2.15e-03 | 2.18e-02 | 14 |
GO:00344706 | Cervix | HSIL_HPV | ncRNA processing | 27/737 | 395/18723 | 4.01e-03 | 3.45e-02 | 27 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0072331 | Colorectum | AD | signal transduction by p53 class mediator | 58/3918 | 163/18723 | 1.04e-05 | 2.40e-04 | 58 |
GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
GO:1901796 | Colorectum | AD | regulation of signal transduction by p53 class mediator | 36/3918 | 93/18723 | 6.58e-05 | 1.07e-03 | 36 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL26 | SNV | Missense_Mutation | c.149G>A | p.Arg50Gln | p.R50Q | P61254 | protein_coding | tolerated(0.11) | benign(0.029) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPL26 | SNV | Missense_Mutation | c.377N>A | p.Arg126His | p.R126H | P61254 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-E2-A1LL-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | docetaxel | PD | |
RPL26 | SNV | Missense_Mutation | novel | c.175N>G | p.Arg59Gly | p.R59G | P61254 | protein_coding | deleterious(0.02) | benign(0.131) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RPL26 | SNV | Missense_Mutation | rs757117420 | c.358N>A | p.Glu120Lys | p.E120K | P61254 | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RPL26 | SNV | Missense_Mutation | c.377G>A | p.Arg126His | p.R126H | P61254 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RPL26 | SNV | Missense_Mutation | novel | c.344N>A | p.Arg115His | p.R115H | P61254 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
RPL26 | SNV | Missense_Mutation | novel | c.87N>G | p.Ile29Met | p.I29M | P61254 | protein_coding | tolerated(0.06) | benign(0.024) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
RPL26 | SNV | Missense_Mutation | novel | c.92C>A | p.Ser31Tyr | p.S31Y | P61254 | protein_coding | deleterious(0) | benign(0.289) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
RPL26 | SNV | Missense_Mutation | novel | c.188A>C | p.Lys63Thr | p.K63T | P61254 | protein_coding | deleterious(0) | possibly_damaging(0.528) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL26 | SNV | Missense_Mutation | c.149N>A | p.Arg50Gln | p.R50Q | P61254 | protein_coding | tolerated(0.11) | benign(0.029) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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