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Gene: RPL10A |
Gene summary for RPL10A |
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Gene information | Species | Human | Gene symbol | RPL10A | Gene ID | 4736 |
Gene name | ribosomal protein L10a | |
Gene Alias | CSA19 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000470 | UniProtAcc | P62906 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4736 | RPL10A | CA_HPV_1 | Human | Cervix | CC | 8.13e-08 | -2.90e-01 | 0.0264 |
4736 | RPL10A | CA_HPV_2 | Human | Cervix | CC | 3.90e-23 | -3.50e-01 | 0.0391 |
4736 | RPL10A | CA_HPV_3 | Human | Cervix | CC | 2.72e-02 | 1.31e-01 | 0.0414 |
4736 | RPL10A | N_HPV_2 | Human | Cervix | N_HPV | 2.30e-02 | -9.41e-02 | -0.0131 |
4736 | RPL10A | CCI_1 | Human | Cervix | CC | 1.89e-47 | -1.66e+00 | 0.528 |
4736 | RPL10A | CCI_2 | Human | Cervix | CC | 7.76e-35 | -1.23e+00 | 0.5249 |
4736 | RPL10A | CCI_3 | Human | Cervix | CC | 1.38e-56 | -1.65e+00 | 0.516 |
4736 | RPL10A | CCII_1 | Human | Cervix | CC | 9.65e-80 | -1.80e+00 | 0.3249 |
4736 | RPL10A | Tumor | Human | Cervix | CC | 2.94e-36 | -3.81e-01 | 0.1241 |
4736 | RPL10A | sample1 | Human | Cervix | CC | 3.16e-03 | -2.24e-01 | 0.0959 |
4736 | RPL10A | sample3 | Human | Cervix | CC | 1.39e-63 | -4.69e-01 | 0.1387 |
4736 | RPL10A | H2 | Human | Cervix | HSIL_HPV | 8.10e-28 | -4.40e-01 | 0.0632 |
4736 | RPL10A | L1 | Human | Cervix | CC | 2.44e-02 | -2.33e-01 | 0.0802 |
4736 | RPL10A | T1 | Human | Cervix | CC | 5.01e-25 | -3.89e-01 | 0.0918 |
4736 | RPL10A | T3 | Human | Cervix | CC | 5.01e-70 | -4.93e-01 | 0.1389 |
4736 | RPL10A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.44e-119 | 2.79e+00 | 0.0155 |
4736 | RPL10A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.06e-48 | 2.88e+00 | -0.1808 |
4736 | RPL10A | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.01e-37 | 3.20e+00 | 0.0216 |
4736 | RPL10A | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.19e-64 | 3.06e+00 | -0.0811 |
4736 | RPL10A | HTA11_78_2000001011 | Human | Colorectum | AD | 1.93e-55 | 2.18e+00 | -0.1088 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160729 | Prostate | BPH | rRNA metabolic process | 65/3107 | 236/18723 | 1.45e-05 | 1.87e-04 | 65 |
GO:009730517 | Prostate | BPH | response to alcohol | 65/3107 | 253/18723 | 1.42e-04 | 1.27e-03 | 65 |
GO:00004705 | Prostate | BPH | maturation of LSU-rRNA | 13/3107 | 28/18723 | 2.22e-04 | 1.78e-03 | 13 |
GO:00344708 | Prostate | BPH | ncRNA processing | 84/3107 | 395/18723 | 8.44e-03 | 3.64e-02 | 84 |
GO:000218119 | Prostate | Tumor | cytoplasmic translation | 115/3246 | 148/18723 | 1.36e-58 | 8.43e-55 | 115 |
GO:002261319 | Prostate | Tumor | ribonucleoprotein complex biogenesis | 159/3246 | 463/18723 | 3.17e-19 | 1.52e-16 | 159 |
GO:004225419 | Prostate | Tumor | ribosome biogenesis | 96/3246 | 299/18723 | 2.76e-10 | 1.51e-08 | 96 |
GO:004227319 | Prostate | Tumor | ribosomal large subunit biogenesis | 34/3246 | 72/18723 | 4.52e-09 | 1.82e-07 | 34 |
GO:000636417 | Prostate | Tumor | rRNA processing | 69/3246 | 225/18723 | 5.98e-07 | 1.26e-05 | 69 |
GO:001607217 | Prostate | Tumor | rRNA metabolic process | 71/3246 | 236/18723 | 9.17e-07 | 1.79e-05 | 71 |
GO:000047014 | Prostate | Tumor | maturation of LSU-rRNA | 14/3246 | 28/18723 | 7.53e-05 | 7.86e-04 | 14 |
GO:009730518 | Prostate | Tumor | response to alcohol | 68/3246 | 253/18723 | 9.02e-05 | 8.88e-04 | 68 |
GO:003447013 | Prostate | Tumor | ncRNA processing | 94/3246 | 395/18723 | 6.02e-04 | 4.31e-03 | 94 |
GO:000218128 | Skin | AK | cytoplasmic translation | 101/1910 | 148/18723 | 5.98e-65 | 3.54e-61 | 101 |
GO:002261328 | Skin | AK | ribonucleoprotein complex biogenesis | 108/1910 | 463/18723 | 8.48e-17 | 6.27e-14 | 108 |
GO:004225427 | Skin | AK | ribosome biogenesis | 73/1910 | 299/18723 | 8.44e-13 | 2.08e-10 | 73 |
GO:000636420 | Skin | AK | rRNA processing | 53/1910 | 225/18723 | 4.35e-09 | 3.30e-07 | 53 |
GO:001607220 | Skin | AK | rRNA metabolic process | 54/1910 | 236/18723 | 9.23e-09 | 6.07e-07 | 54 |
GO:004227327 | Skin | AK | ribosomal large subunit biogenesis | 24/1910 | 72/18723 | 8.63e-08 | 4.02e-06 | 24 |
GO:003447016 | Skin | AK | ncRNA processing | 68/1910 | 395/18723 | 1.12e-05 | 2.33e-04 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0517145 | Cervix | N_HPV | Coronavirus disease - COVID-19 | 47/349 | 232/8465 | 1.79e-20 | 4.86e-18 | 3.80e-18 | 47 |
hsa0301045 | Cervix | N_HPV | Ribosome | 39/349 | 167/8465 | 2.05e-19 | 2.79e-17 | 2.18e-17 | 39 |
hsa0517155 | Cervix | N_HPV | Coronavirus disease - COVID-19 | 47/349 | 232/8465 | 1.79e-20 | 4.86e-18 | 3.80e-18 | 47 |
hsa0301055 | Cervix | N_HPV | Ribosome | 39/349 | 167/8465 | 2.05e-19 | 2.79e-17 | 2.18e-17 | 39 |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa05171 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa030101 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa051711 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa030102 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa051712 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
hsa030103 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa051713 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL10A | SNV | Missense_Mutation | c.193N>C | p.Val65Leu | p.V65L | P62906 | protein_coding | tolerated(0.1) | benign(0.013) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RPL10A | SNV | Missense_Mutation | c.519N>T | p.Lys173Asn | p.K173N | P62906 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
RPL10A | SNV | Missense_Mutation | c.497N>T | p.Ala166Val | p.A166V | P62906 | protein_coding | deleterious(0.04) | possibly_damaging(0.71) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RPL10A | deletion | Frame_Shift_Del | c.404delC | p.Pro135LeufsTer17 | p.P135Lfs*17 | P62906 | protein_coding | TCGA-AA-3692-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | PD | |||
RPL10A | SNV | Missense_Mutation | novel | c.284A>C | p.Lys95Thr | p.K95T | P62906 | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
RPL10A | SNV | Missense_Mutation | novel | c.491N>A | p.Cys164Tyr | p.C164Y | P62906 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-BG-A2L7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
RPL10A | SNV | Missense_Mutation | c.404N>T | p.Pro135Leu | p.P135L | P62906 | protein_coding | deleterious(0.03) | possibly_damaging(0.738) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPL10A | SNV | Missense_Mutation | novel | c.644N>A | p.Arg215His | p.R215H | P62906 | protein_coding | tolerated(0.09) | benign(0.017) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RPL10A | SNV | Missense_Mutation | c.292A>C | p.Lys98Gln | p.K98Q | P62906 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BC-A112-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RPL10A | SNV | Missense_Mutation | novel | c.19N>G | p.Arg7Gly | p.R7G | P62906 | protein_coding | tolerated(0.4) | benign(0.015) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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