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Gene: PIR |
Gene summary for PIR |
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Gene information | Species | Human | Gene symbol | PIR | Gene ID | 8544 |
Gene name | pirin | |
Gene Alias | PIR | |
Cytomap | Xp22.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | A0A024RBX6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8544 | PIR | LZE2T | Human | Esophagus | ESCC | 1.97e-07 | 1.01e+00 | 0.082 |
8544 | PIR | LZE4T | Human | Esophagus | ESCC | 3.27e-38 | 1.53e+00 | 0.0811 |
8544 | PIR | LZE7T | Human | Esophagus | ESCC | 2.64e-11 | 7.92e-01 | 0.0667 |
8544 | PIR | LZE8T | Human | Esophagus | ESCC | 9.11e-14 | 5.65e-01 | 0.067 |
8544 | PIR | LZE20T | Human | Esophagus | ESCC | 4.09e-11 | 4.20e-01 | 0.0662 |
8544 | PIR | LZE22T | Human | Esophagus | ESCC | 6.35e-08 | 7.24e-01 | 0.068 |
8544 | PIR | LZE24T | Human | Esophagus | ESCC | 2.43e-09 | 2.26e-01 | 0.0596 |
8544 | PIR | LZE21T | Human | Esophagus | ESCC | 4.06e-10 | 9.19e-01 | 0.0655 |
8544 | PIR | LZE6T | Human | Esophagus | ESCC | 2.33e-03 | 3.98e-01 | 0.0845 |
8544 | PIR | P2T-E | Human | Esophagus | ESCC | 5.40e-38 | 7.92e-01 | 0.1177 |
8544 | PIR | P4T-E | Human | Esophagus | ESCC | 2.15e-37 | 1.07e+00 | 0.1323 |
8544 | PIR | P5T-E | Human | Esophagus | ESCC | 5.38e-21 | 4.67e-01 | 0.1327 |
8544 | PIR | P8T-E | Human | Esophagus | ESCC | 9.93e-24 | 4.22e-01 | 0.0889 |
8544 | PIR | P9T-E | Human | Esophagus | ESCC | 1.05e-39 | 1.03e+00 | 0.1131 |
8544 | PIR | P10T-E | Human | Esophagus | ESCC | 9.57e-30 | 4.92e-01 | 0.116 |
8544 | PIR | P11T-E | Human | Esophagus | ESCC | 1.25e-06 | 4.85e-01 | 0.1426 |
8544 | PIR | P12T-E | Human | Esophagus | ESCC | 9.99e-35 | 6.27e-01 | 0.1122 |
8544 | PIR | P15T-E | Human | Esophagus | ESCC | 3.44e-71 | 1.75e+00 | 0.1149 |
8544 | PIR | P16T-E | Human | Esophagus | ESCC | 2.24e-16 | 3.05e-01 | 0.1153 |
8544 | PIR | P19T-E | Human | Esophagus | ESCC | 8.88e-07 | 7.60e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005125819 | Prostate | Tumor | protein polymerization | 93/3246 | 297/18723 | 2.22e-09 | 9.58e-08 | 93 |
GO:003227119 | Prostate | Tumor | regulation of protein polymerization | 77/3246 | 233/18723 | 3.76e-09 | 1.54e-07 | 77 |
GO:003227318 | Prostate | Tumor | positive regulation of protein polymerization | 51/3246 | 138/18723 | 2.78e-08 | 9.10e-07 | 51 |
GO:003253518 | Prostate | Tumor | regulation of cellular component size | 109/3246 | 383/18723 | 3.56e-08 | 1.12e-06 | 109 |
GO:000815417 | Prostate | Tumor | actin polymerization or depolymerization | 70/3246 | 218/18723 | 6.91e-08 | 1.97e-06 | 70 |
GO:005165614 | Prostate | Tumor | establishment of organelle localization | 109/3246 | 390/18723 | 9.97e-08 | 2.67e-06 | 109 |
GO:003004117 | Prostate | Tumor | actin filament polymerization | 62/3246 | 191/18723 | 2.47e-07 | 5.72e-06 | 62 |
GO:000806416 | Prostate | Tumor | regulation of actin polymerization or depolymerization | 60/3246 | 188/18723 | 7.30e-07 | 1.47e-05 | 60 |
GO:003083317 | Prostate | Tumor | regulation of actin filament polymerization | 56/3246 | 172/18723 | 8.27e-07 | 1.64e-05 | 56 |
GO:003083215 | Prostate | Tumor | regulation of actin filament length | 60/3246 | 189/18723 | 8.91e-07 | 1.75e-05 | 60 |
GO:000091014 | Prostate | Tumor | cytokinesis | 55/3246 | 173/18723 | 2.37e-06 | 4.02e-05 | 55 |
GO:003083816 | Prostate | Tumor | positive regulation of actin filament polymerization | 36/3246 | 99/18723 | 4.51e-06 | 7.06e-05 | 36 |
GO:004501012 | Prostate | Tumor | actin nucleation | 22/3246 | 52/18723 | 2.14e-05 | 2.75e-04 | 22 |
GO:001082116 | Prostate | Tumor | regulation of mitochondrion organization | 44/3246 | 144/18723 | 6.75e-05 | 7.21e-04 | 44 |
GO:005105413 | Prostate | Tumor | positive regulation of DNA metabolic process | 57/3246 | 201/18723 | 6.77e-05 | 7.21e-04 | 57 |
GO:006164013 | Prostate | Tumor | cytoskeleton-dependent cytokinesis | 33/3246 | 100/18723 | 1.04e-04 | 1.00e-03 | 33 |
GO:200102016 | Prostate | Tumor | regulation of response to DNA damage stimulus | 59/3246 | 219/18723 | 2.37e-04 | 2.01e-03 | 59 |
GO:005105212 | Prostate | Tumor | regulation of DNA metabolic process | 88/3246 | 359/18723 | 3.23e-04 | 2.59e-03 | 88 |
GO:001082213 | Prostate | Tumor | positive regulation of mitochondrion organization | 25/3246 | 74/18723 | 4.62e-04 | 3.47e-03 | 25 |
GO:003250612 | Prostate | Tumor | cytokinetic process | 15/3246 | 39/18723 | 1.42e-03 | 8.80e-03 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PIR | DPC | Skin | ADJ | NAA25,PCAT1,FZD8, etc. | 1.26e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIR | SNV | Missense_Mutation | c.334N>G | p.His112Asp | p.H112D | O00625 | protein_coding | tolerated(0.4) | possibly_damaging(0.455) | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PIR | SNV | Missense_Mutation | rs200350682 | c.587C>T | p.Thr196Met | p.T196M | O00625 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-D8-A1XJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
PIR | SNV | Missense_Mutation | novel | c.397N>C | p.Glu133Gln | p.E133Q | O00625 | protein_coding | deleterious(0) | possibly_damaging(0.806) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PIR | insertion | Frame_Shift_Ins | novel | c.338_339insA | p.Leu114ProfsTer6 | p.L114Pfs*6 | O00625 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
PIR | insertion | Nonsense_Mutation | novel | c.337_338insATTTTGTTTTGTGTTTCTAGTGCAAACAAAAGTAATT | p.Gly113AspfsTer7 | p.G113Dfs*7 | O00625 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
PIR | SNV | Missense_Mutation | rs757971715 | c.539N>T | p.Ala180Val | p.A180V | O00625 | protein_coding | deleterious(0.01) | benign(0.329) | TCGA-EX-A69M-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
PIR | SNV | Missense_Mutation | novel | c.448N>A | p.Ala150Thr | p.A150T | O00625 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PIR | SNV | Missense_Mutation | c.623C>T | p.Ala208Val | p.A208V | O00625 | protein_coding | tolerated(0.37) | benign(0.014) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIR | SNV | Missense_Mutation | c.554C>T | p.Pro185Leu | p.P185L | O00625 | protein_coding | deleterious(0.03) | benign(0.013) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIR | SNV | Missense_Mutation | c.776N>G | p.Asn259Ser | p.N259S | O00625 | protein_coding | tolerated(0.09) | probably_damaging(0.922) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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