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Gene: PDPN |
Gene summary for PDPN |
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Gene information | Species | Human | Gene symbol | PDPN | Gene ID | 10630 |
Gene name | podoplanin | |
Gene Alias | AGGRUS | |
Cytomap | 1p36.21 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q86YL7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10630 | PDPN | LZE6T | Human | Esophagus | ESCC | 3.16e-06 | 3.45e-01 | 0.0845 |
10630 | PDPN | P2T-E | Human | Esophagus | ESCC | 4.40e-21 | 6.38e-01 | 0.1177 |
10630 | PDPN | P4T-E | Human | Esophagus | ESCC | 4.93e-05 | 9.30e-01 | 0.1323 |
10630 | PDPN | P5T-E | Human | Esophagus | ESCC | 2.38e-69 | 1.87e+00 | 0.1327 |
10630 | PDPN | P8T-E | Human | Esophagus | ESCC | 2.76e-07 | 3.79e-01 | 0.0889 |
10630 | PDPN | P9T-E | Human | Esophagus | ESCC | 9.68e-21 | 1.38e+00 | 0.1131 |
10630 | PDPN | P10T-E | Human | Esophagus | ESCC | 2.27e-100 | 3.29e+00 | 0.116 |
10630 | PDPN | P11T-E | Human | Esophagus | ESCC | 3.37e-29 | 2.09e+00 | 0.1426 |
10630 | PDPN | P12T-E | Human | Esophagus | ESCC | 7.94e-30 | 8.49e-01 | 0.1122 |
10630 | PDPN | P15T-E | Human | Esophagus | ESCC | 1.04e-19 | 1.14e+00 | 0.1149 |
10630 | PDPN | P16T-E | Human | Esophagus | ESCC | 8.78e-03 | -4.02e-02 | 0.1153 |
10630 | PDPN | P17T-E | Human | Esophagus | ESCC | 1.36e-09 | 1.12e+00 | 0.1278 |
10630 | PDPN | P19T-E | Human | Esophagus | ESCC | 1.60e-13 | 1.92e+00 | 0.1662 |
10630 | PDPN | P21T-E | Human | Esophagus | ESCC | 4.83e-40 | 1.16e+00 | 0.1617 |
10630 | PDPN | P22T-E | Human | Esophagus | ESCC | 5.67e-44 | 1.12e+00 | 0.1236 |
10630 | PDPN | P23T-E | Human | Esophagus | ESCC | 4.73e-02 | 6.86e-01 | 0.108 |
10630 | PDPN | P26T-E | Human | Esophagus | ESCC | 1.07e-09 | 2.27e-01 | 0.1276 |
10630 | PDPN | P27T-E | Human | Esophagus | ESCC | 5.79e-07 | 3.83e-01 | 0.1055 |
10630 | PDPN | P28T-E | Human | Esophagus | ESCC | 3.45e-09 | 5.16e-01 | 0.1149 |
10630 | PDPN | P30T-E | Human | Esophagus | ESCC | 6.82e-09 | 1.10e+00 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00303237 | Prostate | BPH | respiratory tube development | 48/3107 | 181/18723 | 4.65e-04 | 3.33e-03 | 48 |
GO:00303247 | Prostate | BPH | lung development | 47/3107 | 177/18723 | 5.13e-04 | 3.63e-03 | 47 |
GO:002240915 | Prostate | BPH | positive regulation of cell-cell adhesion | 67/3107 | 284/18723 | 1.41e-03 | 8.40e-03 | 67 |
GO:00341103 | Prostate | BPH | regulation of homotypic cell-cell adhesion | 13/3107 | 33/18723 | 1.50e-03 | 8.85e-03 | 13 |
GO:00075968 | Prostate | BPH | blood coagulation | 53/3107 | 217/18723 | 1.91e-03 | 1.09e-02 | 53 |
GO:00508178 | Prostate | BPH | coagulation | 54/3107 | 222/18723 | 1.92e-03 | 1.09e-02 | 54 |
GO:00605415 | Prostate | BPH | respiratory system development | 50/3107 | 203/18723 | 2.09e-03 | 1.17e-02 | 50 |
GO:00341122 | Prostate | BPH | positive regulation of homotypic cell-cell adhesion | 7/3107 | 13/18723 | 2.33e-03 | 1.27e-02 | 7 |
GO:0010717 | Prostate | BPH | regulation of epithelial to mesenchymal transition | 28/3107 | 99/18723 | 2.42e-03 | 1.31e-02 | 28 |
GO:19031156 | Prostate | BPH | regulation of actin filament-based movement | 14/3107 | 39/18723 | 2.81e-03 | 1.48e-02 | 14 |
GO:00075998 | Prostate | BPH | hemostasis | 53/3107 | 222/18723 | 3.21e-03 | 1.67e-02 | 53 |
GO:00107182 | Prostate | BPH | positive regulation of epithelial to mesenchymal transition | 17/3107 | 52/18723 | 3.30e-03 | 1.71e-02 | 17 |
GO:00726733 | Prostate | BPH | lamellipodium morphogenesis | 8/3107 | 17/18723 | 3.36e-03 | 1.73e-02 | 8 |
GO:00430621 | Prostate | BPH | extracellular structure organization | 67/3107 | 302/18723 | 6.67e-03 | 3.00e-02 | 67 |
GO:00301981 | Prostate | BPH | extracellular matrix organization | 66/3107 | 301/18723 | 9.20e-03 | 3.92e-02 | 66 |
GO:00452291 | Prostate | BPH | external encapsulating structure organization | 66/3107 | 304/18723 | 1.15e-02 | 4.66e-02 | 66 |
GO:003297019 | Prostate | Tumor | regulation of actin filament-based process | 133/3246 | 397/18723 | 2.59e-15 | 4.35e-13 | 133 |
GO:002260418 | Prostate | Tumor | regulation of cell morphogenesis | 102/3246 | 309/18723 | 1.25e-11 | 9.49e-10 | 102 |
GO:004206019 | Prostate | Tumor | wound healing | 127/3246 | 422/18723 | 5.32e-11 | 3.41e-09 | 127 |
GO:003158916 | Prostate | Tumor | cell-substrate adhesion | 109/3246 | 363/18723 | 1.41e-09 | 6.71e-08 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDPN | deletion | Frame_Shift_Del | novel | c.640delG | p.Val214SerfsTer3 | p.V214Sfs*3 | Q86YL7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PDPN | SNV | Missense_Mutation | c.16G>A | p.Gly6Arg | p.G6R | Q86YL7 | protein_coding | tolerated_low_confidence(0.07) | benign(0.013) | TCGA-3L-AA1B-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDPN | SNV | Missense_Mutation | rs140760055 | c.263N>A | p.Gly88Glu | p.G88E | Q86YL7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
PDPN | SNV | Missense_Mutation | c.353N>T | p.Ala118Val | p.A118V | Q86YL7 | protein_coding | tolerated(1) | benign(0) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDPN | SNV | Missense_Mutation | rs377220172 | c.676G>A | p.Val226Ile | p.V226I | Q86YL7 | protein_coding | tolerated(1) | benign(0) | TCGA-AG-4005-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | CR |
PDPN | deletion | Frame_Shift_Del | c.113delN | p.Pro40HisfsTer16 | p.P40Hfs*16 | Q86YL7 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PDPN | SNV | Missense_Mutation | novel | c.327N>T | p.Glu109Asp | p.E109D | Q86YL7 | protein_coding | tolerated(0.53) | benign(0.114) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PDPN | SNV | Missense_Mutation | c.517N>T | p.Pro173Ser | p.P173S | Q86YL7 | protein_coding | tolerated(0.26) | benign(0.086) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PDPN | SNV | Missense_Mutation | c.582N>T | p.Gln194His | p.Q194H | Q86YL7 | protein_coding | deleterious(0.03) | possibly_damaging(0.871) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDPN | SNV | Missense_Mutation | novel | c.434C>T | p.Ala145Val | p.A145V | Q86YL7 | protein_coding | tolerated(0.22) | benign(0.097) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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