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Gene: OBSL1 |
Gene summary for OBSL1 |
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Gene information | Species | Human | Gene symbol | OBSL1 | Gene ID | 23363 |
Gene name | obscurin like cytoskeletal adaptor 1 | |
Gene Alias | OBSL1 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O75147 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23363 | OBSL1 | LZE8T | Human | Esophagus | ESCC | 9.25e-05 | 4.48e-02 | 0.067 |
23363 | OBSL1 | P2T-E | Human | Esophagus | ESCC | 2.55e-15 | 1.74e-01 | 0.1177 |
23363 | OBSL1 | P4T-E | Human | Esophagus | ESCC | 2.02e-06 | 8.24e-02 | 0.1323 |
23363 | OBSL1 | P5T-E | Human | Esophagus | ESCC | 3.55e-09 | 5.74e-02 | 0.1327 |
23363 | OBSL1 | P8T-E | Human | Esophagus | ESCC | 1.10e-17 | 2.64e-01 | 0.0889 |
23363 | OBSL1 | P9T-E | Human | Esophagus | ESCC | 2.73e-12 | 1.63e-01 | 0.1131 |
23363 | OBSL1 | P10T-E | Human | Esophagus | ESCC | 5.78e-26 | 9.04e-02 | 0.116 |
23363 | OBSL1 | P11T-E | Human | Esophagus | ESCC | 9.15e-03 | 2.82e-01 | 0.1426 |
23363 | OBSL1 | P12T-E | Human | Esophagus | ESCC | 1.15e-20 | 1.42e-01 | 0.1122 |
23363 | OBSL1 | P15T-E | Human | Esophagus | ESCC | 9.69e-16 | 1.08e-01 | 0.1149 |
23363 | OBSL1 | P16T-E | Human | Esophagus | ESCC | 1.06e-15 | 2.18e-01 | 0.1153 |
23363 | OBSL1 | P17T-E | Human | Esophagus | ESCC | 4.24e-02 | 7.30e-02 | 0.1278 |
23363 | OBSL1 | P20T-E | Human | Esophagus | ESCC | 6.30e-09 | 1.52e-01 | 0.1124 |
23363 | OBSL1 | P21T-E | Human | Esophagus | ESCC | 1.71e-20 | 2.23e-01 | 0.1617 |
23363 | OBSL1 | P22T-E | Human | Esophagus | ESCC | 5.94e-22 | 1.08e-01 | 0.1236 |
23363 | OBSL1 | P23T-E | Human | Esophagus | ESCC | 9.25e-03 | -6.90e-02 | 0.108 |
23363 | OBSL1 | P24T-E | Human | Esophagus | ESCC | 1.23e-13 | 1.59e-02 | 0.1287 |
23363 | OBSL1 | P26T-E | Human | Esophagus | ESCC | 8.48e-15 | 6.04e-02 | 0.1276 |
23363 | OBSL1 | P27T-E | Human | Esophagus | ESCC | 4.27e-13 | 8.10e-02 | 0.1055 |
23363 | OBSL1 | P28T-E | Human | Esophagus | ESCC | 1.30e-09 | 8.27e-02 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005500112 | Thyroid | ATC | muscle cell development | 81/6293 | 184/18723 | 2.02e-03 | 9.60e-03 | 81 |
GO:003505111 | Thyroid | ATC | cardiocyte differentiation | 70/6293 | 156/18723 | 2.18e-03 | 1.02e-02 | 70 |
GO:005077511 | Thyroid | ATC | positive regulation of dendrite morphogenesis | 20/6293 | 37/18723 | 8.24e-03 | 3.16e-02 | 20 |
GO:005077312 | Thyroid | ATC | regulation of dendrite development | 46/6293 | 103/18723 | 1.26e-02 | 4.42e-02 | 46 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OBSL1 | SNV | Missense_Mutation | c.2265G>T | p.Lys755Asn | p.K755N | O75147 | protein_coding | tolerated(0.28) | benign(0.142) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
OBSL1 | SNV | Missense_Mutation | novel | c.1249N>G | p.Arg417Gly | p.R417G | O75147 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
OBSL1 | SNV | Missense_Mutation | rs768834976 | c.2161N>A | p.Gln721Lys | p.Q721K | O75147 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
OBSL1 | SNV | Missense_Mutation | c.2407N>A | p.Asp803Asn | p.D803N | O75147 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
OBSL1 | SNV | Missense_Mutation | rs757910265 | c.3254N>A | p.Ala1085Glu | p.A1085E | O75147 | protein_coding | tolerated(0.99) | possibly_damaging(0.741) | TCGA-AC-A2QJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
OBSL1 | SNV | Missense_Mutation | rs757910265 | c.3254N>A | p.Ala1085Glu | p.A1085E | O75147 | protein_coding | tolerated(0.99) | possibly_damaging(0.741) | TCGA-AC-A3QP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
OBSL1 | SNV | Missense_Mutation | rs765704645 | c.4766C>T | p.Ser1589Leu | p.S1589L | O75147 | protein_coding | tolerated(0.05) | benign(0.021) | TCGA-AC-A6IV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OBSL1 | SNV | Missense_Mutation | c.4189N>A | p.Ala1397Thr | p.A1397T | O75147 | protein_coding | tolerated(0.51) | benign(0.01) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OBSL1 | SNV | Missense_Mutation | novel | c.2329G>C | p.Glu777Gln | p.E777Q | O75147 | protein_coding | tolerated(0.11) | benign(0.328) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
OBSL1 | SNV | Missense_Mutation | rs757910265 | c.3254N>A | p.Ala1085Glu | p.A1085E | O75147 | protein_coding | tolerated(0.99) | possibly_damaging(0.741) | TCGA-BH-A5J0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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