Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NMT1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NMT1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NMT1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NMT1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NMT1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19054755 | Liver | Cirrhotic | regulation of protein localization to membrane | 76/4634 | 175/18723 | 4.55e-08 | 1.45e-06 | 76 |
GO:00017015 | Liver | Cirrhotic | in utero embryonic development | 134/4634 | 367/18723 | 2.78e-07 | 6.86e-06 | 134 |
GO:00435431 | Liver | Cirrhotic | protein acylation | 95/4634 | 243/18723 | 4.73e-07 | 1.07e-05 | 95 |
GO:00108216 | Liver | Cirrhotic | regulation of mitochondrion organization | 62/4634 | 144/18723 | 1.09e-06 | 2.22e-05 | 62 |
GO:00973455 | Liver | Cirrhotic | mitochondrial outer membrane permeabilization | 20/4634 | 32/18723 | 6.64e-06 | 1.04e-04 | 20 |
GO:00901515 | Liver | Cirrhotic | establishment of protein localization to mitochondrial membrane | 19/4634 | 30/18723 | 8.57e-06 | 1.27e-04 | 19 |
GO:00086377 | Liver | Cirrhotic | apoptotic mitochondrial changes | 47/4634 | 107/18723 | 1.10e-05 | 1.57e-04 | 47 |
GO:004218011 | Liver | Cirrhotic | cellular ketone metabolic process | 80/4634 | 211/18723 | 1.40e-05 | 1.95e-04 | 80 |
GO:19037493 | Liver | Cirrhotic | positive regulation of establishment of protein localization to mitochondrion | 21/4634 | 36/18723 | 1.80e-05 | 2.44e-04 | 21 |
GO:00512053 | Liver | Cirrhotic | protein insertion into membrane | 29/4634 | 57/18723 | 1.88e-05 | 2.53e-04 | 29 |
GO:007121411 | Liver | Cirrhotic | cellular response to abiotic stimulus | 115/4634 | 331/18723 | 2.62e-05 | 3.38e-04 | 115 |
GO:010400411 | Liver | Cirrhotic | cellular response to environmental stimulus | 115/4634 | 331/18723 | 2.62e-05 | 3.38e-04 | 115 |
GO:00512044 | Liver | Cirrhotic | protein insertion into mitochondrial membrane | 16/4634 | 25/18723 | 3.72e-05 | 4.47e-04 | 16 |
GO:00469024 | Liver | Cirrhotic | regulation of mitochondrial membrane permeability | 30/4634 | 63/18723 | 6.83e-05 | 7.74e-04 | 30 |
GO:00905594 | Liver | Cirrhotic | regulation of membrane permeability | 35/4634 | 78/18723 | 8.26e-05 | 9.01e-04 | 35 |
GO:19037473 | Liver | Cirrhotic | regulation of establishment of protein localization to mitochondrion | 25/4634 | 50/18723 | 1.01e-04 | 1.05e-03 | 25 |
GO:19054775 | Liver | Cirrhotic | positive regulation of protein localization to membrane | 44/4634 | 106/18723 | 1.07e-04 | 1.10e-03 | 44 |
GO:0042157 | Liver | Cirrhotic | lipoprotein metabolic process | 53/4634 | 135/18723 | 1.32e-04 | 1.29e-03 | 53 |
GO:19026865 | Liver | Cirrhotic | mitochondrial outer membrane permeabilization involved in programmed cell death | 21/4634 | 40/18723 | 1.48e-04 | 1.42e-03 | 21 |
GO:00357944 | Liver | Cirrhotic | positive regulation of mitochondrial membrane permeability | 22/4634 | 43/18723 | 1.69e-04 | 1.59e-03 | 22 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NMT1 | SNV | Missense_Mutation | | c.344N>A | p.Arg115Gln | p.R115Q | P30419 | protein_coding | tolerated(0.08) | benign(0.138) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | novel | c.763N>T | p.Arg255Cys | p.R255C | P30419 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | novel | c.177N>T | p.Lys59Asn | p.K59N | P30419 | protein_coding | tolerated(0.12) | benign(0.264) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | | c.732N>T | p.Glu244Asp | p.E244D | P30419 | protein_coding | deleterious(0.02) | benign(0.232) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NMT1 | insertion | Frame_Shift_Ins | novel | c.965_966insAGGTATTCATTGTCTGGTGACTTTATATAAGAAAGGAA | p.Thr323GlyfsTer15 | p.T323Gfs*15 | P30419 | protein_coding | | | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD |
NMT1 | insertion | Frame_Shift_Ins | novel | c.792_793insAGTT | p.Arg265SerfsTer45 | p.R265Sfs*45 | P30419 | protein_coding | | | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NMT1 | insertion | Frame_Shift_Ins | novel | c.793_794insCTACCATGCCAGGGGGCAGAAGGATTTGT | p.Arg265ProfsTer47 | p.R265Pfs*47 | P30419 | protein_coding | | | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | novel | c.532G>C | p.Glu178Gln | p.E178Q | P30419 | protein_coding | tolerated(0.1) | probably_damaging(0.996) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
NMT1 | SNV | Missense_Mutation | novel | c.1368N>T | p.Met456Ile | p.M456I | P30419 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | | c.10G>A | p.Glu4Lys | p.E4K | P30419 | protein_coding | deleterious_low_confidence(0.04) | benign(0.017) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |