Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/MICALL2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/MICALL2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MICALL2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/MICALL2_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/MICALL2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/MICALL2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/MICALL2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003432916 | Oral cavity | OSCC | cell junction assembly | 190/7305 | 420/18723 | 4.99e-03 | 1.96e-02 | 190 |
GO:003158932 | Oral cavity | NEOLP | cell-substrate adhesion | 93/2005 | 363/18723 | 4.93e-16 | 2.93e-13 | 93 |
GO:000701534 | Oral cavity | NEOLP | actin filament organization | 94/2005 | 442/18723 | 4.49e-11 | 5.80e-09 | 94 |
GO:003238631 | Oral cavity | NEOLP | regulation of intracellular transport | 77/2005 | 337/18723 | 7.66e-11 | 8.58e-09 | 77 |
GO:003432923 | Oral cavity | NEOLP | cell junction assembly | 88/2005 | 420/18723 | 4.18e-10 | 3.44e-08 | 88 |
GO:005125833 | Oral cavity | NEOLP | protein polymerization | 67/2005 | 297/18723 | 2.27e-09 | 1.40e-07 | 67 |
GO:007259432 | Oral cavity | NEOLP | establishment of protein localization to organelle | 84/2005 | 422/18723 | 1.30e-08 | 6.10e-07 | 84 |
GO:190382932 | Oral cavity | NEOLP | positive regulation of cellular protein localization | 61/2005 | 276/18723 | 2.63e-08 | 1.14e-06 | 61 |
GO:003315731 | Oral cavity | NEOLP | regulation of intracellular protein transport | 53/2005 | 229/18723 | 4.28e-08 | 1.77e-06 | 53 |
GO:003444633 | Oral cavity | NEOLP | substrate adhesion-dependent cell spreading | 32/2005 | 108/18723 | 5.34e-08 | 2.16e-06 | 32 |
GO:004521625 | Oral cavity | NEOLP | cell-cell junction organization | 47/2005 | 200/18723 | 1.51e-07 | 5.21e-06 | 47 |
GO:003238831 | Oral cavity | NEOLP | positive regulation of intracellular transport | 45/2005 | 202/18723 | 1.35e-06 | 3.46e-05 | 45 |
GO:000815431 | Oral cavity | NEOLP | actin polymerization or depolymerization | 47/2005 | 218/18723 | 2.11e-06 | 4.91e-05 | 47 |
GO:190495133 | Oral cavity | NEOLP | positive regulation of establishment of protein localization | 61/2005 | 319/18723 | 4.85e-06 | 1.03e-04 | 61 |
GO:003153232 | Oral cavity | NEOLP | actin cytoskeleton reorganization | 28/2005 | 107/18723 | 5.43e-06 | 1.12e-04 | 28 |
GO:003004132 | Oral cavity | NEOLP | actin filament polymerization | 41/2005 | 191/18723 | 1.03e-05 | 1.94e-04 | 41 |
GO:009031631 | Oral cavity | NEOLP | positive regulation of intracellular protein transport | 36/2005 | 160/18723 | 1.18e-05 | 2.15e-04 | 36 |
GO:005122233 | Oral cavity | NEOLP | positive regulation of protein transport | 57/2005 | 303/18723 | 1.62e-05 | 2.79e-04 | 57 |
GO:000704318 | Oral cavity | NEOLP | cell-cell junction assembly | 33/2005 | 146/18723 | 2.42e-05 | 3.84e-04 | 33 |
GO:004329717 | Oral cavity | NEOLP | apical junction assembly | 20/2005 | 78/18723 | 1.55e-04 | 1.76e-03 | 20 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MICALL2 | SNV | Missense_Mutation | | c.288G>C | p.Leu96Phe | p.L96F | Q8IY33 | protein_coding | deleterious(0.01) | possibly_damaging(0.906) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
MICALL2 | SNV | Missense_Mutation | novel | c.1862N>A | p.Pro621His | p.P621H | Q8IY33 | protein_coding | deleterious(0) | possibly_damaging(0.737) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
MICALL2 | SNV | Missense_Mutation | rs747674926 | c.1451N>G | p.Ser484Cys | p.S484C | Q8IY33 | protein_coding | tolerated(0.05) | benign(0.009) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MICALL2 | insertion | Frame_Shift_Ins | rs751396826 | c.1284_1285insC | p.Gly429ArgfsTer61 | p.G429Rfs*61 | Q8IY33 | protein_coding | | | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MICALL2 | SNV | Missense_Mutation | novel | c.1291A>G | p.Ser431Gly | p.S431G | Q8IY33 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MICALL2 | SNV | Missense_Mutation | rs374682289 | c.1910N>A | p.Thr637Asn | p.T637N | Q8IY33 | protein_coding | tolerated(0.07) | benign(0.307) | TCGA-C5-A2M1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MICALL2 | SNV | Missense_Mutation | rs760862909 | c.1138G>A | p.Gly380Arg | p.G380R | Q8IY33 | protein_coding | tolerated(0.53) | benign(0.086) | TCGA-C5-A2M2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MICALL2 | SNV | Missense_Mutation | novel | c.362N>T | p.Ala121Val | p.A121V | Q8IY33 | protein_coding | deleterious(0) | benign(0.042) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MICALL2 | SNV | Missense_Mutation | | c.2625N>A | p.Met875Ile | p.M875I | Q8IY33 | protein_coding | deleterious(0.01) | benign(0.231) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MICALL2 | SNV | Missense_Mutation | | c.1010N>A | p.Arg337His | p.R337H | Q8IY33 | protein_coding | tolerated(0.17) | benign(0) | TCGA-LP-A7HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |