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Gene: JUND |
Gene summary for JUND |
Gene summary. |
Gene information | Species | Human | Gene symbol | JUND | Gene ID | 3727 |
Gene name | JunD proto-oncogene, AP-1 transcription factor subunit | |
Gene Alias | AP-1 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | P17535 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3727 | JUND | GSM4909281 | Human | Breast | IDC | 2.81e-18 | -6.16e-01 | 0.21 |
3727 | JUND | GSM4909282 | Human | Breast | IDC | 3.34e-05 | -3.72e-01 | -0.0288 |
3727 | JUND | GSM4909285 | Human | Breast | IDC | 2.27e-22 | -6.72e-01 | 0.21 |
3727 | JUND | GSM4909286 | Human | Breast | IDC | 2.66e-24 | -6.41e-01 | 0.1081 |
3727 | JUND | GSM4909290 | Human | Breast | IDC | 4.59e-10 | -6.03e-01 | 0.2096 |
3727 | JUND | GSM4909291 | Human | Breast | IDC | 6.16e-07 | 4.49e-01 | 0.1753 |
3727 | JUND | GSM4909293 | Human | Breast | IDC | 5.51e-51 | 8.27e-01 | 0.1581 |
3727 | JUND | GSM4909294 | Human | Breast | IDC | 6.19e-06 | -3.06e-01 | 0.2022 |
3727 | JUND | GSM4909296 | Human | Breast | IDC | 3.16e-08 | -3.86e-01 | 0.1524 |
3727 | JUND | GSM4909297 | Human | Breast | IDC | 5.89e-30 | -6.39e-01 | 0.1517 |
3727 | JUND | GSM4909301 | Human | Breast | IDC | 1.52e-30 | 5.55e-01 | 0.1577 |
3727 | JUND | GSM4909303 | Human | Breast | IDC | 4.47e-11 | 6.50e-01 | 0.0438 |
3727 | JUND | GSM4909304 | Human | Breast | IDC | 2.71e-14 | 4.39e-01 | 0.1636 |
3727 | JUND | GSM4909306 | Human | Breast | IDC | 1.38e-10 | -4.98e-01 | 0.1564 |
3727 | JUND | GSM4909307 | Human | Breast | IDC | 1.68e-08 | -4.63e-01 | 0.1569 |
3727 | JUND | GSM4909308 | Human | Breast | IDC | 6.04e-07 | -1.77e-01 | 0.158 |
3727 | JUND | GSM4909311 | Human | Breast | IDC | 3.96e-31 | -3.44e-01 | 0.1534 |
3727 | JUND | GSM4909313 | Human | Breast | IDC | 4.00e-07 | 3.05e-01 | 0.0391 |
3727 | JUND | GSM4909315 | Human | Breast | IDC | 1.71e-06 | 2.17e-01 | 0.21 |
3727 | JUND | GSM4909319 | Human | Breast | IDC | 2.05e-40 | -5.52e-01 | 0.1563 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004343422 | Liver | HCC | response to peptide hormone | 247/7958 | 414/18723 | 9.55e-13 | 4.77e-11 | 247 |
GO:001003822 | Liver | HCC | response to metal ion | 208/7958 | 373/18723 | 1.35e-07 | 2.56e-06 | 208 |
GO:000756822 | Liver | HCC | aging | 185/7958 | 339/18723 | 4.28e-06 | 5.50e-05 | 185 |
GO:000762321 | Liver | HCC | circadian rhythm | 117/7958 | 210/18723 | 7.29e-05 | 6.54e-04 | 117 |
GO:004851121 | Liver | HCC | rhythmic process | 156/7958 | 298/18723 | 3.54e-04 | 2.46e-03 | 156 |
GO:003249611 | Liver | HCC | response to lipopolysaccharide | 174/7958 | 343/18723 | 1.19e-03 | 6.62e-03 | 174 |
GO:007124112 | Liver | HCC | cellular response to inorganic substance | 119/7958 | 226/18723 | 1.26e-03 | 6.92e-03 | 119 |
GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
GO:005159221 | Liver | HCC | response to calcium ion | 81/7958 | 149/18723 | 2.26e-03 | 1.13e-02 | 81 |
GO:000223711 | Liver | HCC | response to molecule of bacterial origin | 181/7958 | 363/18723 | 2.58e-03 | 1.24e-02 | 181 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
GO:007124812 | Liver | HCC | cellular response to metal ion | 101/7958 | 197/18723 | 7.82e-03 | 3.10e-02 | 101 |
GO:000164911 | Liver | HCC | osteoblast differentiation | 115/7958 | 229/18723 | 1.08e-02 | 3.99e-02 | 115 |
GO:000756818 | Oral cavity | OSCC | aging | 194/7305 | 339/18723 | 6.18e-12 | 2.33e-10 | 194 |
GO:000931416 | Oral cavity | OSCC | response to radiation | 241/7305 | 456/18723 | 9.76e-10 | 2.40e-08 | 241 |
GO:003249617 | Oral cavity | OSCC | response to lipopolysaccharide | 178/7305 | 343/18723 | 7.27e-07 | 1.03e-05 | 178 |
GO:004851116 | Oral cavity | OSCC | rhythmic process | 157/7305 | 298/18723 | 1.00e-06 | 1.36e-05 | 157 |
GO:004343419 | Oral cavity | OSCC | response to peptide hormone | 208/7305 | 414/18723 | 1.83e-06 | 2.35e-05 | 208 |
GO:001003820 | Oral cavity | OSCC | response to metal ion | 188/7305 | 373/18723 | 4.34e-06 | 5.00e-05 | 188 |
GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0465716 | Breast | Precancer | IL-17 signaling pathway | 20/684 | 94/8465 | 4.74e-05 | 4.54e-04 | 3.48e-04 | 20 |
hsa0465717 | Breast | Precancer | IL-17 signaling pathway | 20/684 | 94/8465 | 4.74e-05 | 4.54e-04 | 3.48e-04 | 20 |
hsa0465721 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465731 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465741 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465751 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465718 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0492812 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0465719 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0492813 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa0401012 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0465742 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465752 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa04928 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa049281 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa049282 | Colorectum | SER | Parathyroid hormone synthesis, secretion and action | 31/1580 | 106/8465 | 5.20e-03 | 3.28e-02 | 2.38e-02 | 31 |
hsa049283 | Colorectum | SER | Parathyroid hormone synthesis, secretion and action | 31/1580 | 106/8465 | 5.20e-03 | 3.28e-02 | 2.38e-02 | 31 |
hsa049284 | Colorectum | MSS | Parathyroid hormone synthesis, secretion and action | 37/1875 | 106/8465 | 1.72e-03 | 9.13e-03 | 5.59e-03 | 37 |
hsa049285 | Colorectum | MSS | Parathyroid hormone synthesis, secretion and action | 37/1875 | 106/8465 | 1.72e-03 | 9.13e-03 | 5.59e-03 | 37 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JUND | SNV | Missense_Mutation | novel | c.412N>A | p.Glu138Lys | p.E138K | P17535 | protein_coding | deleterious(0) | possibly_damaging(0.812) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
JUND | SNV | Missense_Mutation | c.790N>T | p.Asp264Tyr | p.D264Y | P17535 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
JUND | SNV | Missense_Mutation | c.856N>T | p.Arg286Cys | p.R286C | P17535 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
JUND | SNV | Missense_Mutation | c.344N>T | p.Thr115Ile | p.T115I | P17535 | protein_coding | tolerated(0.16) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
JUND | SNV | Missense_Mutation | novel | c.979A>G | p.Lys327Glu | p.K327E | P17535 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
JUND | SNV | Missense_Mutation | rs751981092 | c.436G>A | p.Asp146Asn | p.D146N | P17535 | protein_coding | deleterious(0.04) | probably_damaging(0.954) | TCGA-UB-A7MA-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Chemotherapy | gemcitabine | PD |
JUND | SNV | Missense_Mutation | c.654N>T | p.Glu218Asp | p.E218D | P17535 | protein_coding | tolerated(0.79) | benign(0.003) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
JUND | SNV | Missense_Mutation | c.362C>T | p.Ser121Leu | p.S121L | P17535 | protein_coding | tolerated(0.08) | benign(0.013) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
JUND | SNV | Missense_Mutation | novel | c.410C>T | p.Ala137Val | p.A137V | P17535 | protein_coding | deleterious(0.02) | possibly_damaging(0.645) | TCGA-77-A5GH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
JUND | deletion | Frame_Shift_Del | novel | c.256_289delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Gly86SerfsTer101 | p.G86Sfs*101 | P17535 | protein_coding | TCGA-62-8394-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3727 | JUND | TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR | CLOZAPINE | CLOZAPINE | 12093589 |
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