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Gene: ITPA |
Gene summary for ITPA |
Gene summary. |
Gene information | Species | Human | Gene symbol | ITPA | Gene ID | 3704 |
Gene name | inosine triphosphatase | |
Gene Alias | C20orf37 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0S2Z423 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3704 | ITPA | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.22e-03 | 3.14e-01 | -0.1808 |
3704 | ITPA | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.32e-06 | 4.73e-01 | -0.0811 |
3704 | ITPA | HTA11_347_2000001011 | Human | Colorectum | AD | 2.08e-05 | 2.60e-01 | -0.1954 |
3704 | ITPA | HTA11_696_2000001011 | Human | Colorectum | AD | 2.49e-05 | 3.34e-01 | -0.1464 |
3704 | ITPA | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.18e-07 | 5.57e-01 | -0.059 |
3704 | ITPA | HTA11_866_3004761011 | Human | Colorectum | AD | 3.45e-15 | 7.00e-01 | 0.096 |
3704 | ITPA | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.11e-04 | 7.55e-01 | 0.0171 |
3704 | ITPA | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.31e-04 | 4.33e-01 | 0.0338 |
3704 | ITPA | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.00e-14 | 4.77e-01 | 0.0674 |
3704 | ITPA | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.11e-02 | 3.21e-01 | 0.294 |
3704 | ITPA | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.70e-08 | 6.33e-01 | 0.281 |
3704 | ITPA | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.41e-03 | 6.00e-01 | 0.2585 |
3704 | ITPA | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.30e-24 | 7.23e-01 | 0.3005 |
3704 | ITPA | A015-C-203 | Human | Colorectum | FAP | 2.26e-03 | -9.56e-02 | -0.1294 |
3704 | ITPA | A015-C-104 | Human | Colorectum | FAP | 1.48e-04 | 3.79e-03 | -0.1899 |
3704 | ITPA | A002-C-016 | Human | Colorectum | FAP | 5.75e-03 | -1.10e-01 | 0.0521 |
3704 | ITPA | A002-C-116 | Human | Colorectum | FAP | 5.13e-05 | -1.37e-01 | -0.0452 |
3704 | ITPA | LZE4T | Human | Esophagus | ESCC | 3.87e-18 | 3.53e-01 | 0.0811 |
3704 | ITPA | LZE7T | Human | Esophagus | ESCC | 6.73e-10 | 6.85e-01 | 0.0667 |
3704 | ITPA | LZE8T | Human | Esophagus | ESCC | 2.66e-10 | 2.49e-01 | 0.067 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000914426 | Thyroid | PTC | purine nucleoside triphosphate metabolic process | 53/5968 | 88/18723 | 3.91e-08 | 8.51e-07 | 53 |
GO:001969327 | Thyroid | PTC | ribose phosphate metabolic process | 176/5968 | 396/18723 | 8.28e-08 | 1.70e-06 | 176 |
GO:000915028 | Thyroid | PTC | purine ribonucleotide metabolic process | 165/5968 | 368/18723 | 1.03e-07 | 2.05e-06 | 165 |
GO:000920526 | Thyroid | PTC | purine ribonucleoside triphosphate metabolic process | 49/5968 | 82/18723 | 1.78e-07 | 3.33e-06 | 49 |
GO:007252127 | Thyroid | PTC | purine-containing compound metabolic process | 182/5968 | 416/18723 | 1.92e-07 | 3.51e-06 | 182 |
GO:000914127 | Thyroid | PTC | nucleoside triphosphate metabolic process | 62/5968 | 112/18723 | 2.26e-07 | 4.00e-06 | 62 |
GO:000925927 | Thyroid | PTC | ribonucleotide metabolic process | 170/5968 | 385/18723 | 2.32e-07 | 4.08e-06 | 170 |
GO:000919920 | Thyroid | PTC | ribonucleoside triphosphate metabolic process | 50/5968 | 89/18723 | 1.81e-06 | 2.50e-05 | 50 |
GO:000616327 | Thyroid | PTC | purine nucleotide metabolic process | 170/5968 | 396/18723 | 2.02e-06 | 2.75e-05 | 170 |
GO:000675325 | Thyroid | PTC | nucleoside phosphate metabolic process | 205/5968 | 497/18723 | 5.24e-06 | 6.35e-05 | 205 |
GO:000911725 | Thyroid | PTC | nucleotide metabolic process | 202/5968 | 489/18723 | 5.46e-06 | 6.60e-05 | 202 |
GO:00092006 | Thyroid | PTC | deoxyribonucleoside triphosphate metabolic process | 11/5968 | 17/18723 | 5.46e-03 | 2.49e-02 | 11 |
GO:003465525 | Thyroid | ATC | nucleobase-containing compound catabolic process | 217/6293 | 407/18723 | 1.20e-16 | 1.04e-14 | 217 |
GO:004670024 | Thyroid | ATC | heterocycle catabolic process | 228/6293 | 445/18723 | 7.26e-15 | 4.50e-13 | 228 |
GO:004427025 | Thyroid | ATC | cellular nitrogen compound catabolic process | 229/6293 | 451/18723 | 2.25e-14 | 1.27e-12 | 229 |
GO:001943924 | Thyroid | ATC | aromatic compound catabolic process | 232/6293 | 467/18723 | 3.05e-13 | 1.44e-11 | 232 |
GO:190136124 | Thyroid | ATC | organic cyclic compound catabolic process | 238/6293 | 495/18723 | 1.12e-11 | 4.12e-10 | 238 |
GO:001969328 | Thyroid | ATC | ribose phosphate metabolic process | 184/6293 | 396/18723 | 5.87e-08 | 1.05e-06 | 184 |
GO:000915029 | Thyroid | ATC | purine ribonucleotide metabolic process | 172/6293 | 368/18723 | 9.58e-08 | 1.64e-06 | 172 |
GO:000925928 | Thyroid | ATC | ribonucleotide metabolic process | 178/6293 | 385/18723 | 1.47e-07 | 2.39e-06 | 178 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa00983 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa009831 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa009832 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa009833 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0123221 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0123231 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITPA | SNV | Missense_Mutation | c.481N>A | p.Glu161Lys | p.E161K | Q9BY32 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ITPA | SNV | Missense_Mutation | rs142979373 | c.128N>T | p.Pro43Leu | p.P43L | Q9BY32 | protein_coding | tolerated(0.07) | benign(0.17) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
ITPA | SNV | Missense_Mutation | novel | c.562T>G | p.Tyr188Asp | p.Y188D | Q9BY32 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR |
ITPA | SNV | Missense_Mutation | rs777033296 | c.70N>A | p.Val24Ile | p.V24I | Q9BY32 | protein_coding | tolerated(0.32) | benign(0) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITPA | SNV | Missense_Mutation | rs776945646 | c.202N>A | p.Val68Met | p.V68M | Q9BY32 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ITPA | SNV | Missense_Mutation | rs538432614 | c.117N>C | p.Lys39Asn | p.K39N | Q9BY32 | protein_coding | tolerated(0.28) | benign(0.009) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ITPA | SNV | Missense_Mutation | rs201119006 | c.184N>T | p.Arg62Cys | p.R62C | Q9BY32 | protein_coding | deleterious(0.01) | benign(0.018) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ITPA | SNV | Missense_Mutation | novel | c.457N>T | p.Pro153Ser | p.P153S | Q9BY32 | protein_coding | tolerated(0.13) | benign(0.21) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPA | SNV | Missense_Mutation | novel | c.19N>A | p.Gly7Arg | p.G7R | Q9BY32 | protein_coding | tolerated(0.14) | benign(0.005) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
ITPA | SNV | Missense_Mutation | novel | c.424G>A | p.Ala142Thr | p.A142T | Q9BY32 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3704 | ITPA | ENZYME | peginterferon alfa-2b | 26441325,23730840,21274861,26916827,26670100,20173735,26071337,23707372,26438033,21246582,27833958,20547162,21503919,20637204 | ||
3704 | ITPA | ENZYME | ribavirin | RIBAVIRIN | 26441325,25713999,23730840,21274861,26916827,26670100,20173735,26071337,23707372,26438033,21246582,27833958,20547162,21503919,20637204 | |
3704 | ITPA | ENZYME | peginterferon alfa-2a | 25713999 | ||
3704 | ITPA | ENZYME | mercaptopurine | MERCAPTOPURINE | 26237184,18685564,21395650 | |
3704 | ITPA | ENZYME | methotrexate | METHOTREXATE | 26237184,19858780,27217051,29520081,16947783 | |
3704 | ITPA | ENZYME | purine analogues | 19129747 | ||
3704 | ITPA | ENZYME | azathioprine | AZATHIOPRINE | 26674571,16431304,21961091,18616518,18662289,15973722,19129747 | |
3704 | ITPA | ENZYME | interferon alfa-2b, recombinant | 21503919 |
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