Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: INSIG2

Gene summary for INSIG2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

INSIG2

Gene ID

51141

Gene nameinsulin induced gene 2
Gene AliasINSIG-2
Cytomap2q14.1-q14.2
Gene Typeprotein-coding
GO ID

GO:0001501

UniProtAcc

A0A024RAI2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51141INSIG2GSM4909296HumanBreastIDC6.97e-03-1.15e-010.1524
51141INSIG2GSM4909301HumanBreastIDC7.26e-03-1.21e-010.1577
51141INSIG2GSM4909302HumanBreastIDC6.39e-05-1.47e-010.1545
51141INSIG2GSM4909311HumanBreastIDC2.13e-09-1.07e-010.1534
51141INSIG2GSM4909319HumanBreastIDC1.78e-08-1.51e-010.1563
51141INSIG2GSM4909321HumanBreastIDC1.41e-05-1.38e-010.1559
51141INSIG2ctrl6HumanBreastPrecancer3.36e-085.47e-01-0.0061
51141INSIG2brca1HumanBreastPrecancer1.20e-023.17e-01-0.0338
51141INSIG2brca3HumanBreastPrecancer1.88e-114.68e-01-0.0263
51141INSIG2brca10HumanBreastPrecancer1.38e-064.19e-01-0.0029
51141INSIG2NCCBC14HumanBreastDCIS3.06e-028.68e-020.2021
51141INSIG2NCCBC3HumanBreastDCIS4.70e-03-1.23e-020.1198
51141INSIG2NCCBC5HumanBreastDCIS3.38e-02-8.35e-020.2046
51141INSIG2P1HumanBreastIDC8.85e-05-8.61e-020.1527
51141INSIG2DCIS2HumanBreastDCIS7.27e-341.51e-020.0085
51141INSIG2LZE4THumanEsophagusESCC7.12e-073.24e-010.0811
51141INSIG2LZE7THumanEsophagusESCC1.09e-052.54e-010.0667
51141INSIG2LZE8THumanEsophagusESCC1.96e-071.54e-010.067
51141INSIG2LZE24THumanEsophagusESCC3.39e-151.86e-010.0596
51141INSIG2LZE6THumanEsophagusESCC5.56e-031.73e-010.0845
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00363141LiverHCCresponse to sterol24/795836/187232.95e-031.38e-0224
GO:00192172LiverHCCregulation of fatty acid metabolic process53/795893/187233.36e-031.53e-0253
GO:00192182LiverHCCregulation of steroid metabolic process55/7958100/187237.79e-033.09e-0255
GO:005123518Oral cavityOSCCmaintenance of location182/7305327/187236.16e-101.58e-08182
GO:003250710Oral cavityOSCCmaintenance of protein location in cell49/730565/187232.61e-096.03e-0849
GO:004518520Oral cavityOSCCmaintenance of protein location65/730594/187233.00e-096.88e-0865
GO:190165316Oral cavityOSCCcellular response to peptide194/7305359/187234.31e-099.57e-08194
GO:00725958Oral cavityOSCCmaintenance of protein localization in organelle35/730542/187234.58e-091.01e-0735
GO:00069849Oral cavityOSCCER-nucleus signaling pathway36/730546/187236.49e-081.16e-0636
GO:005165120Oral cavityOSCCmaintenance of location in cell121/7305214/187231.39e-072.32e-06121
GO:003286916Oral cavityOSCCcellular response to insulin stimulus114/7305203/187235.07e-077.41e-06114
GO:00709729Oral cavityOSCCprotein localization to endoplasmic reticulum50/730574/187236.03e-078.64e-0650
GO:007137510Oral cavityOSCCcellular response to peptide hormone stimulus153/7305290/187231.23e-061.63e-05153
GO:004343419Oral cavityOSCCresponse to peptide hormone208/7305414/187231.83e-062.35e-05208
GO:00060667Oral cavityOSCCalcohol metabolic process179/7305353/187234.54e-065.21e-05179
GO:003286816Oral cavityOSCCresponse to insulin138/7305264/187237.54e-068.15e-05138
GO:00421804Oral cavityOSCCcellular ketone metabolic process111/7305211/187233.94e-053.45e-04111
GO:00461652Oral cavityOSCCalcohol biosynthetic process77/7305140/187238.77e-056.70e-0477
GO:00160537Oral cavityOSCCorganic acid biosynthetic process155/7305316/187231.64e-041.13e-03155
GO:00463947Oral cavityOSCCcarboxylic acid biosynthetic process154/7305314/187231.73e-041.19e-03154
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
INSIG2SNVMissense_Mutationnovelc.439N>Gp.Thr147Alap.T147AQ9Y5U4protein_codingtolerated(0.54)probably_damaging(0.983)TCGA-A2-A0T1-01Breastbreast invasive carcinomaFemale<65III/IVTargeted Molecular therapyherceptinSD
INSIG2SNVMissense_Mutationrs758358013c.382N>Ap.Asp128Asnp.D128NQ9Y5U4protein_codingdeleterious(0.04)benign(0.083)TCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
INSIG2SNVMissense_Mutationc.565N>Tp.Arg189Cysp.R189CQ9Y5U4protein_codingdeleterious(0)benign(0.007)TCGA-D8-A1JA-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinPD
INSIG2SNVMissense_Mutationc.365G>Ap.Ser122Asnp.S122NQ9Y5U4protein_codingtolerated(0.07)benign(0.095)TCGA-E2-A15J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydocetaxelSD
INSIG2SNVMissense_Mutationnovelc.362C>Tp.Ala121Valp.A121VQ9Y5U4protein_codingdeleterious(0)benign(0.183)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
INSIG2SNVMissense_Mutationc.623G>Ap.Arg208Glnp.R208QQ9Y5U4protein_codingdeleterious(0)probably_damaging(0.988)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
INSIG2SNVMissense_Mutationnovelc.44G>Ap.Gly15Aspp.G15DQ9Y5U4protein_codingdeleterious_low_confidence(0.01)benign(0.133)TCGA-AA-3949-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownSD
INSIG2SNVMissense_Mutationrs758358013c.382N>Ap.Asp128Asnp.D128NQ9Y5U4protein_codingdeleterious(0.04)benign(0.083)TCGA-CK-4951-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
INSIG2SNVMissense_Mutationc.565N>Tp.Arg189Cysp.R189CQ9Y5U4protein_codingdeleterious(0)benign(0.007)TCGA-F5-6814-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
INSIG2insertionFrame_Shift_Insnovelc.585_586insTp.Ala198CysfsTer19p.A198Cfs*19Q9Y5U4protein_codingTCGA-G4-6628-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
51141INSIG2NAantipsychotics20877301,18195716,20373477
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