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Gene: HSD17B1 |
Gene summary for HSD17B1 |
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Gene information | Species | Human | Gene symbol | HSD17B1 | Gene ID | 3292 |
Gene name | hydroxysteroid 17-beta dehydrogenase 1 | |
Gene Alias | 17-beta-HSD | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P14061 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3292 | HSD17B1 | LZE4T | Human | Esophagus | ESCC | 2.61e-07 | 1.87e-01 | 0.0811 |
3292 | HSD17B1 | P2T-E | Human | Esophagus | ESCC | 2.51e-05 | 1.49e-01 | 0.1177 |
3292 | HSD17B1 | P4T-E | Human | Esophagus | ESCC | 7.59e-11 | 3.06e-01 | 0.1323 |
3292 | HSD17B1 | P5T-E | Human | Esophagus | ESCC | 5.00e-29 | 5.68e-01 | 0.1327 |
3292 | HSD17B1 | P8T-E | Human | Esophagus | ESCC | 6.64e-11 | 1.01e-01 | 0.0889 |
3292 | HSD17B1 | P9T-E | Human | Esophagus | ESCC | 5.28e-04 | 1.92e-01 | 0.1131 |
3292 | HSD17B1 | P12T-E | Human | Esophagus | ESCC | 1.69e-02 | 2.64e-02 | 0.1122 |
3292 | HSD17B1 | P15T-E | Human | Esophagus | ESCC | 2.10e-02 | 6.50e-02 | 0.1149 |
3292 | HSD17B1 | P16T-E | Human | Esophagus | ESCC | 3.87e-03 | 3.75e-02 | 0.1153 |
3292 | HSD17B1 | P21T-E | Human | Esophagus | ESCC | 9.51e-11 | 2.40e-01 | 0.1617 |
3292 | HSD17B1 | P22T-E | Human | Esophagus | ESCC | 2.73e-49 | 8.56e-01 | 0.1236 |
3292 | HSD17B1 | P23T-E | Human | Esophagus | ESCC | 4.40e-05 | 2.12e-01 | 0.108 |
3292 | HSD17B1 | P24T-E | Human | Esophagus | ESCC | 1.81e-08 | 2.32e-01 | 0.1287 |
3292 | HSD17B1 | P26T-E | Human | Esophagus | ESCC | 3.90e-15 | 3.21e-01 | 0.1276 |
3292 | HSD17B1 | P27T-E | Human | Esophagus | ESCC | 3.07e-08 | 1.47e-01 | 0.1055 |
3292 | HSD17B1 | P28T-E | Human | Esophagus | ESCC | 4.39e-23 | 4.17e-01 | 0.1149 |
3292 | HSD17B1 | P30T-E | Human | Esophagus | ESCC | 6.24e-04 | 2.13e-01 | 0.137 |
3292 | HSD17B1 | P31T-E | Human | Esophagus | ESCC | 3.13e-07 | 1.08e-01 | 0.1251 |
3292 | HSD17B1 | P32T-E | Human | Esophagus | ESCC | 2.65e-24 | 3.65e-01 | 0.1666 |
3292 | HSD17B1 | P37T-E | Human | Esophagus | ESCC | 8.23e-08 | 2.31e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00344707 | Endometrium | AEH | ncRNA processing | 62/2100 | 395/18723 | 3.93e-03 | 2.65e-02 | 62 |
GO:003447012 | Endometrium | EEC | ncRNA processing | 63/2168 | 395/18723 | 5.20e-03 | 3.26e-02 | 63 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:003158919 | Esophagus | ESCC | cell-substrate adhesion | 221/8552 | 363/18723 | 3.06e-09 | 6.62e-08 | 221 |
GO:001081020 | Esophagus | ESCC | regulation of cell-substrate adhesion | 144/8552 | 221/18723 | 3.55e-09 | 7.45e-08 | 144 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:004578527 | Esophagus | ESCC | positive regulation of cell adhesion | 255/8552 | 437/18723 | 5.07e-08 | 9.11e-07 | 255 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:001081126 | Esophagus | ESCC | positive regulation of cell-substrate adhesion | 84/8552 | 123/18723 | 3.18e-07 | 4.50e-06 | 84 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSD17B1 | SNV | Missense_Mutation | novel | c.367N>A | p.Leu123Met | p.L123M | protein_coding | deleterious(0.04) | possibly_damaging(0.697) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HSD17B1 | SNV | Missense_Mutation | c.400N>A | p.Gly134Ser | p.G134S | protein_coding | tolerated(0.13) | benign(0.206) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
HSD17B1 | SNV | Missense_Mutation | c.144N>T | p.Glu48Asp | p.E48D | protein_coding | tolerated(0.07) | possibly_damaging(0.717) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HSD17B1 | SNV | Missense_Mutation | c.609G>T | p.Glu203Asp | p.E203D | protein_coding | tolerated(0.62) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
HSD17B1 | SNV | Missense_Mutation | rs773613890 | c.530N>G | p.Phe177Cys | p.F177C | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AX-A2H2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD17B1 | SNV | Missense_Mutation | c.320N>T | p.Ala107Val | p.A107V | protein_coding | deleterious(0.02) | possibly_damaging(0.571) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
HSD17B1 | SNV | Missense_Mutation | novel | c.337N>A | p.Asp113Asn | p.D113N | protein_coding | deleterious(0.04) | benign(0.359) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HSD17B1 | SNV | Missense_Mutation | novel | c.283G>T | p.Gly95Cys | p.G95C | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD17B1 | SNV | Missense_Mutation | c.404N>G | p.Ser135Trp | p.S135W | protein_coding | tolerated(0.05) | benign(0.35) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
HSD17B1 | SNV | Missense_Mutation | c.868C>T | p.Pro290Ser | p.P290S | protein_coding | tolerated(0.15) | benign(0.023) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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