Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/HNRNPL_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/HNRNPL_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/HNRNPL_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HNRNPL_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HNRNPL_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HNRNPL_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/HNRNPL_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HNRNPL_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004802428 | Skin | cSCC | regulation of mRNA splicing, via spliceosome | 67/4864 | 101/18723 | 1.83e-17 | 1.98e-15 | 67 |
GO:0000380110 | Skin | cSCC | alternative mRNA splicing, via spliceosome | 47/4864 | 77/18723 | 9.03e-11 | 4.04e-09 | 47 |
GO:0033120111 | Skin | cSCC | positive regulation of RNA splicing | 27/4864 | 37/18723 | 2.95e-09 | 1.03e-07 | 27 |
GO:0000381110 | Skin | cSCC | regulation of alternative mRNA splicing, via spliceosome | 33/4864 | 60/18723 | 1.66e-06 | 2.79e-05 | 33 |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:0000375113 | Thyroid | PTC | RNA splicing, via transesterification reactions | 202/5968 | 324/18723 | 6.81e-30 | 3.91e-27 | 202 |
GO:0000377113 | Thyroid | PTC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:0000398113 | Thyroid | PTC | mRNA splicing, via spliceosome | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:1903311112 | Thyroid | PTC | regulation of mRNA metabolic process | 181/5968 | 288/18723 | 1.60e-27 | 5.94e-25 | 181 |
GO:0050684112 | Thyroid | PTC | regulation of mRNA processing | 98/5968 | 137/18723 | 1.53e-21 | 3.10e-19 | 98 |
GO:0043484113 | Thyroid | PTC | regulation of RNA splicing | 102/5968 | 148/18723 | 2.03e-20 | 3.21e-18 | 102 |
GO:0048024113 | Thyroid | PTC | regulation of mRNA splicing, via spliceosome | 71/5968 | 101/18723 | 2.39e-15 | 1.71e-13 | 71 |
GO:0000380111 | Thyroid | PTC | alternative mRNA splicing, via spliceosome | 51/5968 | 77/18723 | 6.09e-10 | 1.92e-08 | 51 |
GO:0000381111 | Thyroid | PTC | regulation of alternative mRNA splicing, via spliceosome | 37/5968 | 60/18723 | 1.93e-06 | 2.64e-05 | 37 |
GO:0043484210 | Thyroid | goiters | regulation of RNA splicing | 19/497 | 148/18723 | 1.44e-08 | 1.49e-06 | 19 |
GO:0048024210 | Thyroid | goiters | regulation of mRNA splicing, via spliceosome | 14/497 | 101/18723 | 4.46e-07 | 3.02e-05 | 14 |
GO:000037728 | Thyroid | goiters | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 26/497 | 320/18723 | 4.75e-07 | 3.12e-05 | 26 |
GO:000039828 | Thyroid | goiters | mRNA splicing, via spliceosome | 26/497 | 320/18723 | 4.75e-07 | 3.12e-05 | 26 |
GO:000037528 | Thyroid | goiters | RNA splicing, via transesterification reactions | 26/497 | 324/18723 | 6.03e-07 | 3.78e-05 | 26 |
GO:000838029 | Thyroid | goiters | RNA splicing | 31/497 | 434/18723 | 6.49e-07 | 3.95e-05 | 31 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPL | SNV | Missense_Mutation | | c.1540N>A | p.Glu514Lys | p.E514K | P14866 | protein_coding | deleterious(0.03) | benign(0.033) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
HNRNPL | SNV | Missense_Mutation | novel | c.502N>A | p.Pro168Thr | p.P168T | P14866 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-A7-A3RF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD |
HNRNPL | SNV | Missense_Mutation | | c.1391N>T | p.Ser464Leu | p.S464L | P14866 | protein_coding | tolerated(0.51) | benign(0.059) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HNRNPL | SNV | Missense_Mutation | novel | c.1560N>G | p.Ile520Met | p.I520M | P14866 | protein_coding | tolerated(0.23) | benign(0.001) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
HNRNPL | insertion | Frame_Shift_Ins | novel | c.850_851insCCTTAGAAACCAGCAGTGGCTCCTTTGAGAGTCTGGTGAGGGT | p.Asp284AlafsTer26 | p.D284Afs*26 | P14866 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
HNRNPL | insertion | Frame_Shift_Ins | novel | c.1284_1285insAG | p.Gly429ArgfsTer5 | p.G429Rfs*5 | P14866 | protein_coding | | | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPL | insertion | In_Frame_Ins | novel | c.1283_1284insGGGCCCAATTTCACAAGAACCGCATTGGCG | p.Asp428delinsGluGlyProIleSerGlnGluProHisTrpArg | p.D428delinsEGPISQEPHWR | P14866 | protein_coding | | | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPL | SNV | Missense_Mutation | | c.1021N>A | p.Glu341Lys | p.E341K | P14866 | protein_coding | tolerated(0.56) | benign(0.018) | TCGA-C5-A1MI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
HNRNPL | SNV | Missense_Mutation | | c.719N>T | p.Ser240Leu | p.S240L | P14866 | protein_coding | tolerated(0.09) | benign(0.057) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HNRNPL | SNV | Missense_Mutation | | c.796N>A | p.Glu266Lys | p.E266K | P14866 | protein_coding | deleterious(0.02) | benign(0.017) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |