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Gene: FZD6 |
Gene summary for FZD6 |
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Gene information | Species | Human | Gene symbol | FZD6 | Gene ID | 8323 |
Gene name | frizzled class receptor 6 | |
Gene Alias | FZ-6 | |
Cytomap | 8q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001736 | UniProtAcc | A0A024R9E9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8323 | FZD6 | CA_HPV_1 | Human | Cervix | CC | 2.54e-02 | -1.49e-01 | 0.0264 |
8323 | FZD6 | CCI_2 | Human | Cervix | CC | 1.09e-04 | 8.08e-01 | 0.5249 |
8323 | FZD6 | Tumor | Human | Cervix | CC | 7.08e-28 | 6.57e-01 | 0.1241 |
8323 | FZD6 | sample3 | Human | Cervix | CC | 2.55e-27 | 5.94e-01 | 0.1387 |
8323 | FZD6 | T3 | Human | Cervix | CC | 4.15e-25 | 5.80e-01 | 0.1389 |
8323 | FZD6 | LZE2T | Human | Esophagus | ESCC | 1.30e-05 | 8.66e-01 | 0.082 |
8323 | FZD6 | LZE4T | Human | Esophagus | ESCC | 4.54e-29 | 9.92e-01 | 0.0811 |
8323 | FZD6 | LZE7T | Human | Esophagus | ESCC | 2.15e-07 | 4.01e-01 | 0.0667 |
8323 | FZD6 | LZE8T | Human | Esophagus | ESCC | 1.43e-05 | 2.23e-01 | 0.067 |
8323 | FZD6 | LZE20T | Human | Esophagus | ESCC | 5.23e-11 | 3.83e-01 | 0.0662 |
8323 | FZD6 | LZE24T | Human | Esophagus | ESCC | 2.72e-21 | 7.38e-01 | 0.0596 |
8323 | FZD6 | LZE21T | Human | Esophagus | ESCC | 2.49e-04 | 3.15e-01 | 0.0655 |
8323 | FZD6 | LZE6T | Human | Esophagus | ESCC | 1.35e-03 | 3.76e-02 | 0.0845 |
8323 | FZD6 | P1T-E | Human | Esophagus | ESCC | 2.07e-03 | 2.97e-01 | 0.0875 |
8323 | FZD6 | P2T-E | Human | Esophagus | ESCC | 2.05e-39 | 7.79e-01 | 0.1177 |
8323 | FZD6 | P4T-E | Human | Esophagus | ESCC | 1.27e-22 | 6.34e-01 | 0.1323 |
8323 | FZD6 | P5T-E | Human | Esophagus | ESCC | 2.78e-21 | 4.13e-01 | 0.1327 |
8323 | FZD6 | P8T-E | Human | Esophagus | ESCC | 2.68e-22 | 5.78e-01 | 0.0889 |
8323 | FZD6 | P9T-E | Human | Esophagus | ESCC | 1.01e-18 | 6.00e-01 | 0.1131 |
8323 | FZD6 | P10T-E | Human | Esophagus | ESCC | 2.36e-60 | 1.11e+00 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000184310 | Thyroid | PTC | neural tube closure | 49/5968 | 88/18723 | 3.24e-06 | 4.20e-05 | 49 |
GO:00606069 | Thyroid | PTC | tube closure | 49/5968 | 89/18723 | 4.99e-06 | 6.08e-05 | 49 |
GO:003514819 | Thyroid | PTC | tube formation | 73/5968 | 148/18723 | 7.04e-06 | 8.31e-05 | 73 |
GO:006056219 | Thyroid | PTC | epithelial tube morphogenesis | 141/5968 | 325/18723 | 7.52e-06 | 8.73e-05 | 141 |
GO:007217515 | Thyroid | PTC | epithelial tube formation | 66/5968 | 132/18723 | 1.08e-05 | 1.19e-04 | 66 |
GO:0030901111 | Thyroid | PTC | midbrain development | 48/5968 | 90/18723 | 1.95e-05 | 1.99e-04 | 48 |
GO:00163318 | Thyroid | PTC | morphogenesis of embryonic epithelium | 71/5968 | 147/18723 | 2.31e-05 | 2.29e-04 | 71 |
GO:005109016 | Thyroid | PTC | regulation of DNA-binding transcription factor activity | 178/5968 | 440/18723 | 7.63e-05 | 6.54e-04 | 178 |
GO:003017810 | Thyroid | PTC | negative regulation of Wnt signaling pathway | 74/5968 | 170/18723 | 8.99e-04 | 5.48e-03 | 74 |
GO:00900907 | Thyroid | PTC | negative regulation of canonical Wnt signaling pathway | 59/5968 | 137/18723 | 3.76e-03 | 1.80e-02 | 59 |
GO:00017389 | Thyroid | PTC | morphogenesis of a polarized epithelium | 41/5968 | 94/18723 | 1.10e-02 | 4.38e-02 | 41 |
GO:001605525 | Thyroid | ATC | Wnt signaling pathway | 234/6293 | 444/18723 | 4.64e-17 | 4.31e-15 | 234 |
GO:019873825 | Thyroid | ATC | cell-cell signaling by wnt | 234/6293 | 446/18723 | 9.26e-17 | 8.25e-15 | 234 |
GO:003011125 | Thyroid | ATC | regulation of Wnt signaling pathway | 177/6293 | 328/18723 | 1.83e-14 | 1.05e-12 | 177 |
GO:004206034 | Thyroid | ATC | wound healing | 210/6293 | 422/18723 | 3.33e-12 | 1.37e-10 | 210 |
GO:006082825 | Thyroid | ATC | regulation of canonical Wnt signaling pathway | 134/6293 | 253/18723 | 1.49e-10 | 4.56e-09 | 134 |
GO:006007025 | Thyroid | ATC | canonical Wnt signaling pathway | 154/6293 | 303/18723 | 3.68e-10 | 1.02e-08 | 154 |
GO:006056222 | Thyroid | ATC | epithelial tube morphogenesis | 156/6293 | 325/18723 | 4.48e-08 | 8.14e-07 | 156 |
GO:000184119 | Thyroid | ATC | neural tube formation | 59/6293 | 102/18723 | 4.28e-07 | 6.25e-06 | 59 |
GO:002191515 | Thyroid | ATC | neural tube development | 80/6293 | 152/18723 | 9.87e-07 | 1.29e-05 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0522510 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
hsa05224 | Cervix | CC | Breast cancer | 32/1267 | 147/8465 | 1.66e-02 | 4.88e-02 | 2.88e-02 | 32 |
hsa0501019 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0520517 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0516512 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa0431012 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0522513 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
hsa052241 | Cervix | CC | Breast cancer | 32/1267 | 147/8465 | 1.66e-02 | 4.88e-02 | 2.88e-02 | 32 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
WNT5A | FZD6 | WNT5A_FZD6 | ncWNT | Cervix | ADJ |
WNT7B | FZD6_LRP5 | WNT7B_FZD6_LRP5 | WNT | Cervix | ADJ |
WNT5A | FZD6 | WNT5A_FZD6 | ncWNT | Cervix | CC |
WNT5B | FZD6 | WNT5B_FZD6 | ncWNT | Cervix | CC |
WNT2B | FZD6_LRP5 | WNT2B_FZD6_LRP5 | WNT | Cervix | CC |
WNT9A | FZD6_LRP5 | WNT9A_FZD6_LRP5 | WNT | Cervix | CC |
WNT2B | FZD6_LRP6 | WNT2B_FZD6_LRP6 | WNT | Cervix | CC |
WNT9A | FZD6_LRP6 | WNT9A_FZD6_LRP6 | WNT | Cervix | CC |
WNT5B | FZD6 | WNT5B_FZD6 | ncWNT | CRC | MSI-H |
WNT5A | FZD6 | WNT5A_FZD6 | ncWNT | Endometrium | ADJ |
WNT2 | FZD6_LRP5 | WNT2_FZD6_LRP5 | WNT | Endometrium | ADJ |
WNT4 | FZD6_LRP5 | WNT4_FZD6_LRP5 | WNT | Endometrium | ADJ |
WNT2 | FZD6_LRP6 | WNT2_FZD6_LRP6 | WNT | Endometrium | ADJ |
WNT4 | FZD6_LRP6 | WNT4_FZD6_LRP6 | WNT | Endometrium | ADJ |
WNT2 | FZD6_LRP6 | WNT2_FZD6_LRP6 | WNT | Endometrium | EEC |
WNT2B | FZD6_LRP6 | WNT2B_FZD6_LRP6 | WNT | Endometrium | EEC |
WNT5A | FZD6 | WNT5A_FZD6 | ncWNT | Esophagus | ESCC |
WNT5B | FZD6 | WNT5B_FZD6 | ncWNT | Esophagus | ESCC |
WNT10A | FZD6_LRP6 | WNT10A_FZD6_LRP6 | WNT | Esophagus | ESCC |
WNT10B | FZD6_LRP6 | WNT10B_FZD6_LRP6 | WNT | Esophagus | ESCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FZD6 | SNV | Missense_Mutation | c.795N>C | p.Glu265Asp | p.E265D | O60353 | protein_coding | tolerated(0.47) | benign(0.02) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
FZD6 | SNV | Missense_Mutation | novel | c.1516N>G | p.Phe506Val | p.F506V | O60353 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FZD6 | SNV | Missense_Mutation | rs201432167 | c.1939N>T | p.Arg647Trp | p.R647W | O60353 | protein_coding | deleterious_low_confidence(0) | benign(0.394) | TCGA-BH-A204-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FZD6 | SNV | Missense_Mutation | c.1045N>A | p.Glu349Lys | p.E349K | O60353 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
FZD6 | SNV | Missense_Mutation | novel | c.226N>C | p.Phe76Leu | p.F76L | O60353 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
FZD6 | SNV | Missense_Mutation | rs186016315 | c.1213C>T | p.Arg405Trp | p.R405W | O60353 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FZD6 | SNV | Missense_Mutation | c.683N>C | p.Arg228Thr | p.R228T | O60353 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EK-A2H0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FZD6 | SNV | Missense_Mutation | rs763949530 | c.1247N>A | p.Arg416Gln | p.R416Q | O60353 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FZD6 | SNV | Missense_Mutation | c.683N>C | p.Arg228Thr | p.R228T | O60353 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-ZJ-A8QQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
FZD6 | SNV | Missense_Mutation | novel | c.383N>G | p.Tyr128Cys | p.Y128C | O60353 | protein_coding | tolerated(0.17) | possibly_damaging(0.796) | TCGA-AA-3837-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8323 | FZD6 | CELL SURFACE, G PROTEIN COUPLED RECEPTOR, KINASE | agonist | 135651914 | ||
8323 | FZD6 | CELL SURFACE, G PROTEIN COUPLED RECEPTOR, KINASE | agonist | 135651915 | ||
8323 | FZD6 | CELL SURFACE, G PROTEIN COUPLED RECEPTOR, KINASE | agonist | 135651916 | ||
8323 | FZD6 | CELL SURFACE, G PROTEIN COUPLED RECEPTOR, KINASE | agonist | 381745008 |
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