Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: FGA

Gene summary for FGA

Gene summary.

Gene information	Species	Human
	Gene symbol	FGA
	Gene ID	2243
	Gene name	fibrinogen alpha chain
	Gene Alias	Fib2
	Cytomap	4q31.3
	Gene Type	protein-coding
	GO ID	GO:0000165
	UniProtAcc	P02671

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
2243	FGA	NAFLD1	Human	Liver	NAFLD	1.94e-07	8.24e-01	-0.04
2243	FGA	S41	Human	Liver	Cirrhotic	1.88e-06	7.12e-01	-0.0343
2243	FGA	S43	Human	Liver	Cirrhotic	6.34e-40	1.12e+00	-0.0187
2243	FGA	S44	Human	Liver	HCC	3.17e-08	1.14e+00	-0.0083
2243	FGA	HCC1_Meng	Human	Liver	HCC	1.24e-62	1.94e-01	0.0246
2243	FGA	HCC2_Meng	Human	Liver	HCC	2.02e-25	-8.38e-01	0.0107
2243	FGA	cirrhotic1	Human	Liver	Cirrhotic	4.26e-22	2.99e-02	0.0202
2243	FGA	cirrhotic2	Human	Liver	Cirrhotic	2.01e-22	2.88e-01	0.0201
2243	FGA	cirrhotic3	Human	Liver	Cirrhotic	5.14e-06	-2.85e-01	0.0215
2243	FGA	p6	Human	Liver	Cyst	2.30e-02	-8.55e-01	-0.0218
2243	FGA	HCC1	Human	Liver	HCC	4.79e-34	6.99e+00	0.5336
2243	FGA	HCC2	Human	Liver	HCC	2.26e-37	8.23e+00	0.5341
2243	FGA	Pt13.a	Human	Liver	HCC	3.56e-41	6.22e-01	0.021
2243	FGA	Pt13.b	Human	Liver	HCC	1.35e-85	5.86e-01	0.0251
2243	FGA	Pt13.c	Human	Liver	HCC	2.13e-46	1.06e+00	0.0076
2243	FGA	Pt14.a	Human	Liver	HCC	2.68e-11	6.82e-01	0.0169
2243	FGA	Pt14.b	Human	Liver	HCC	4.09e-19	5.67e-01	0.018
2243	FGA	Pt14.c	Human	Liver	HCC	3.89e-02	4.04e-01	0.0054
2243	FGA	Pt14.d	Human	Liver	HCC	1.11e-21	6.00e-01	0.0143
2243	FGA	S027	Human	Liver	HCC	7.69e-20	4.19e+00	0.2446

Page: 1 2

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Liver		HCC: Hepatocellular carcinoma
Liver		NAFLD: Non-alcoholic fatty liver disease

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:005122222	Liver	HCC	positive regulation of protein transport	194/7958	303/18723	2.41e-14	1.56e-12	194
GO:000690021	Liver	HCC	vesicle budding from membrane	53/7958	61/18723	7.38e-13	3.80e-11	53
GO:009719122	Liver	HCC	extrinsic apoptotic signaling pathway	143/7958	219/18723	6.99e-12	2.97e-10	143
GO:200123412	Liver	HCC	negative regulation of apoptotic signaling pathway	145/7958	224/18723	1.33e-11	5.36e-10	145
GO:005125822	Liver	HCC	protein polymerization	182/7958	297/18723	4.17e-11	1.58e-09	182
GO:002260422	Liver	HCC	regulation of cell morphogenesis	188/7958	309/18723	4.84e-11	1.82e-09	188
GO:005165621	Liver	HCC	establishment of organelle localization	226/7958	390/18723	4.15e-10	1.34e-08	226
GO:200123621	Liver	HCC	regulation of extrinsic apoptotic signaling pathway	98/7958	151/18723	2.17e-08	5.08e-07	98
GO:005165021	Liver	HCC	establishment of vesicle localization	103/7958	161/18723	2.94e-08	6.69e-07	103
GO:005160412	Liver	HCC	protein maturation	171/7958	294/18723	3.80e-08	8.30e-07	171
GO:001003822	Liver	HCC	response to metal ion	208/7958	373/18723	1.35e-07	2.56e-06	208
GO:00481991	Liver	HCC	vesicle targeting, to, from or within Golgi	20/7958	21/18723	4.57e-07	7.50e-06	20
GO:001076922	Liver	HCC	regulation of cell morphogenesis involved in differentiation	65/7958	96/18723	5.17e-07	8.37e-06	65
GO:000726521	Liver	HCC	Ras protein signal transduction	187/7958	337/18723	8.89e-07	1.35e-05	187
GO:005164821	Liver	HCC	vesicle localization	107/7958	177/18723	1.05e-06	1.57e-05	107
GO:190002422	Liver	HCC	regulation of substrate adhesion-dependent cell spreading	42/7958	57/18723	1.75e-06	2.45e-05	42
GO:000862511	Liver	HCC	extrinsic apoptotic signaling pathway via death domain receptors	55/7958	82/18723	5.97e-06	7.35e-05	55
GO:000690311	Liver	HCC	vesicle targeting	34/7958	45/18723	6.75e-06	8.08e-05	34
GO:00301932	Liver	HCC	regulation of blood coagulation	46/7958	66/18723	7.12e-06	8.47e-05	46
GO:001077022	Liver	HCC	positive regulation of cell morphogenesis involved in differentiation	53/7958	79/18723	8.69e-06	1.02e-04	53

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19

Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa0517114	Liver	NAFLD	Coronavirus disease - COVID-19	111/1043	232/8465	1.01e-41	3.32e-39	2.67e-39	111
hsa04610	Liver	NAFLD	Complement and coagulation cascades	35/1043	86/8465	2.48e-11	2.04e-09	1.64e-09	35
hsa0517115	Liver	NAFLD	Coronavirus disease - COVID-19	111/1043	232/8465	1.01e-41	3.32e-39	2.67e-39	111
hsa046101	Liver	NAFLD	Complement and coagulation cascades	35/1043	86/8465	2.48e-11	2.04e-09	1.64e-09	35
hsa0517122	Liver	Cirrhotic	Coronavirus disease - COVID-19	136/2530	232/8465	3.28e-20	1.82e-18	1.12e-18	136
hsa046102	Liver	Cirrhotic	Complement and coagulation cascades	48/2530	86/8465	4.41e-07	5.44e-06	3.35e-06	48
hsa0517132	Liver	Cirrhotic	Coronavirus disease - COVID-19	136/2530	232/8465	3.28e-20	1.82e-18	1.12e-18	136
hsa046103	Liver	Cirrhotic	Complement and coagulation cascades	48/2530	86/8465	4.41e-07	5.44e-06	3.35e-06	48
hsa0517142	Liver	HCC	Coronavirus disease - COVID-19	167/4020	232/8465	1.50e-14	4.19e-13	2.33e-13	167
hsa046104	Liver	HCC	Complement and coagulation cascades	57/4020	86/8465	3.19e-04	1.45e-03	8.04e-04	57
hsa046112	Liver	HCC	Platelet activation	71/4020	124/8465	1.77e-02	4.15e-02	2.31e-02	71
hsa0517152	Liver	HCC	Coronavirus disease - COVID-19	167/4020	232/8465	1.50e-14	4.19e-13	2.33e-13	167
hsa046105	Liver	HCC	Complement and coagulation cascades	57/4020	86/8465	3.19e-04	1.45e-03	8.04e-04	57
hsa0461111	Liver	HCC	Platelet activation	71/4020	124/8465	1.77e-02	4.15e-02	2.31e-02	71
hsa0517162	Liver	Cyst	Coronavirus disease - COVID-19	75/339	232/8465	2.97e-49	4.27e-47	3.53e-47	75
hsa0517172	Liver	Cyst	Coronavirus disease - COVID-19	75/339	232/8465	2.97e-49	4.27e-47	3.53e-47	75

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

FGA

SNV

Missense_Mutation

c.1663N>G

p.Thr555Ala

p.T555A

P02671

protein_coding

tolerated(0.08)

benign(0.046)

TCGA-A2-A0SW-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Hormone Therapy

arimidex

FGA

SNV

Missense_Mutation

c.1443N>C

p.Glu481Asp

p.E481D

P02671

protein_coding

deleterious(0.01)

probably_damaging(0.998)

TCGA-AR-A24L-01

Breast

breast invasive carcinoma

Female

<65

I/II

Hormone Therapy

tamoxiphen

FGA

SNV

Missense_Mutation

rs745321779

c.878G>T

p.Gly293Val

p.G293V

P02671

protein_coding

deleterious(0.01)

possibly_damaging(0.784)

TCGA-BH-A0DZ-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

docetaxel

FGA

SNV

Missense_Mutation

c.74N>T

p.Gly25Val

p.G25V

P02671

protein_coding

deleterious(0.02)

possibly_damaging(0.861)

TCGA-BH-A18V-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

FGA

SNV

Missense_Mutation

c.633N>A

p.Asp211Glu

p.D211E

P02671

protein_coding

tolerated(0.13)

benign(0.001)

TCGA-C8-A274-01

Breast

breast invasive carcinoma

Female

<65

I/II

Hormone Therapy

tamoxiphen

FGA

SNV

Missense_Mutation

novel

c.2422N>G

p.Trp808Gly

p.W808G

P02671

protein_coding

deleterious(0)

probably_damaging(1)

TCGA-E2-A1LA-01

Breast

breast invasive carcinoma

Female

<65

I/II

Hormone Therapy

arimidex

FGA

insertion

In_Frame_Ins

novel

c.1375_1376insAATTTACTAGTAGCACGAGTTACAACAGAGGAG

p.Arg459delinsGlnPheThrSerSerThrSerTyrAsnArgGlyGly

p.R459delinsQFTSSTSYNRGG

P02671

protein_coding

TCGA-A7-A0CJ-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cytoxan

FGA

insertion

Nonsense_Mutation

novel

c.1980_1981insATCATTACATAAT

p.Val661IlefsTer4

p.V661Ifs*4

P02671

protein_coding

TCGA-A8-A08J-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Unknown

FGA

insertion

Nonsense_Mutation

novel

c.1771_1772insTTCTTTCCTAAATATAAAT

p.Arg591IlefsTer4

p.R591Ifs*4

P02671

protein_coding

TCGA-AO-A03R-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

FGA

SNV

Missense_Mutation

c.2245N>A

p.Glu749Lys

p.E749K

P02671

protein_coding

deleterious(0.02)

benign(0.121)

TCGA-C5-A1BQ-01

Cervix

cervical & endocervical cancer

Female

>=65

III/IV

Chemotherapy

cisplatin

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID	Symbol	Category	Interaction Types	Drug Claim Name	Drug Name	PMIDs
2243	FGA	CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, FIBRINOGEN		RETEPLASE	RETEPLASE
2243	FGA	CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, FIBRINOGEN		RECOMBINANT FACTOR IX FC FUSION PROTEIN
2243	FGA	CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, FIBRINOGEN		ALFIMEPRASE	ALFIMEPRASE
2243	FGA	CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, FIBRINOGEN		ANISTREPLASE	ANISTREPLASE
2243	FGA	CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, FIBRINOGEN	inhibitor	CHEMBL1201505	FIBRINOLYSIN, HUMAN
2243	FGA	CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, FIBRINOGEN		eptifibatide	EPTIFIBATIDE	20938371
2243	FGA	CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, FIBRINOGEN		tirofiban	TIROFIBAN	20938371
2243	FGA	CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, FIBRINOGEN		abciximab	ABCIXIMAB	20938371
2243	FGA	CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, FIBRINOGEN		ALTEPLASE	ALTEPLASE

Page: 1