Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ERP29

Gene summary for ERP29

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ERP29

Gene ID

10961

Gene nameendoplasmic reticulum protein 29
Gene AliasC12orf8
Cytomap12q24.13
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

P30040


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10961ERP29CA_HPV_1HumanCervixCC8.62e-116.48e-020.0264
10961ERP29CA_HPV_3HumanCervixCC1.02e-021.98e-010.0414
10961ERP29CCI_1HumanCervixCC5.69e-08-5.86e-010.528
10961ERP29CCI_3HumanCervixCC3.53e-05-5.36e-010.516
10961ERP29CCII_1HumanCervixCC6.01e-19-7.08e-010.3249
10961ERP29sample3HumanCervixCC4.02e-025.51e-020.1387
10961ERP29L1HumanCervixCC3.21e-11-4.04e-010.0802
10961ERP29HTA11_3410_2000001011HumanColorectumAD8.00e-255.45e-010.0155
10961ERP29HTA11_2487_2000001011HumanColorectumSER3.45e-217.47e-01-0.1808
10961ERP29HTA11_2951_2000001011HumanColorectumAD3.72e-117.48e-010.0216
10961ERP29HTA11_1938_2000001011HumanColorectumAD3.08e-187.71e-01-0.0811
10961ERP29HTA11_78_2000001011HumanColorectumAD4.52e-155.78e-01-0.1088
10961ERP29HTA11_347_2000001011HumanColorectumAD6.00e-481.04e+00-0.1954
10961ERP29HTA11_411_2000001011HumanColorectumSER3.33e-079.64e-01-0.2602
10961ERP29HTA11_2112_2000001011HumanColorectumSER2.86e-046.92e-01-0.2196
10961ERP29HTA11_3361_2000001011HumanColorectumAD2.27e-259.90e-01-0.1207
10961ERP29HTA11_83_2000001011HumanColorectumSER5.41e-229.20e-01-0.1526
10961ERP29HTA11_696_2000001011HumanColorectumAD2.20e-451.07e+00-0.1464
10961ERP29HTA11_866_2000001011HumanColorectumAD1.17e-267.62e-01-0.1001
10961ERP29HTA11_1391_2000001011HumanColorectumAD1.17e-351.09e+00-0.059
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00434107Oral cavityOSCCpositive regulation of MAPK cascade213/7305480/187238.71e-033.16e-02213
GO:000645719Oral cavityLPprotein folding125/4623212/187231.62e-268.45e-24125
GO:0097193110Oral cavityLPintrinsic apoptotic signaling pathway146/4623288/187239.76e-222.78e-19146
GO:0034976110Oral cavityLPresponse to endoplasmic reticulum stress133/4623256/187233.84e-219.24e-19133
GO:2001233110Oral cavityLPregulation of apoptotic signaling pathway168/4623356/187231.35e-203.02e-18168
GO:2001242110Oral cavityLPregulation of intrinsic apoptotic signaling pathway95/4623164/187239.85e-201.99e-1795
GO:1905897110Oral cavityLPregulation of response to endoplasmic reticulum stress45/462382/187234.58e-091.91e-0745
GO:0070059110Oral cavityLPintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress33/462363/187232.09e-064.76e-0533
GO:190223515Oral cavityLPregulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway20/462332/187236.39e-061.26e-0420
GO:007190015Oral cavityLPregulation of protein serine/threonine kinase activity119/4623359/187231.70e-041.90e-03119
GO:004340512Oral cavityLPregulation of MAP kinase activity62/4623177/187231.29e-031.04e-0262
GO:190495012Oral cavityLPnegative regulation of establishment of protein localization47/4623131/187232.73e-031.92e-0247
GO:005122412Oral cavityLPnegative regulation of protein transport45/4623127/187234.33e-032.78e-0245
GO:200123318ProstateBPHregulation of apoptotic signaling pathway134/3107356/187235.06e-227.84e-19134
GO:009719318ProstateBPHintrinsic apoptotic signaling pathway110/3107288/187237.36e-192.85e-16110
GO:000645716ProstateBPHprotein folding85/3107212/187232.37e-164.74e-1485
GO:003497618ProstateBPHresponse to endoplasmic reticulum stress95/3107256/187231.54e-152.52e-1395
GO:200124218ProstateBPHregulation of intrinsic apoptotic signaling pathway70/3107164/187232.34e-153.72e-1370
GO:190589718ProstateBPHregulation of response to endoplasmic reticulum stress34/310782/187238.14e-082.05e-0634
GO:003367416ProstateBPHpositive regulation of kinase activity122/3107467/187238.59e-082.14e-06122
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0414120CervixCCProtein processing in endoplasmic reticulum55/1267174/84651.74e-082.68e-071.58e-0755
hsa04141110CervixCCProtein processing in endoplasmic reticulum55/1267174/84651.74e-082.68e-071.58e-0755
hsa04141ColorectumADProtein processing in endoplasmic reticulum80/2092174/84655.96e-101.25e-087.96e-0980
hsa041411ColorectumADProtein processing in endoplasmic reticulum80/2092174/84655.96e-101.25e-087.96e-0980
hsa041412ColorectumSERProtein processing in endoplasmic reticulum60/1580174/84654.20e-077.33e-065.32e-0660
hsa041413ColorectumSERProtein processing in endoplasmic reticulum60/1580174/84654.20e-077.33e-065.32e-0660
hsa041414ColorectumMSSProtein processing in endoplasmic reticulum75/1875174/84653.78e-108.44e-095.17e-0975
hsa041415ColorectumMSSProtein processing in endoplasmic reticulum75/1875174/84653.78e-108.44e-095.17e-0975
hsa041416ColorectumMSI-HProtein processing in endoplasmic reticulum46/797174/84654.53e-119.78e-108.19e-1046
hsa041417ColorectumMSI-HProtein processing in endoplasmic reticulum46/797174/84654.53e-119.78e-108.19e-1046
hsa0414126EndometriumAEHProtein processing in endoplasmic reticulum62/1197174/84655.97e-131.39e-111.01e-1162
hsa04141111EndometriumAEHProtein processing in endoplasmic reticulum62/1197174/84655.97e-131.39e-111.01e-1162
hsa0414127EndometriumEECProtein processing in endoplasmic reticulum64/1237174/84652.17e-135.09e-123.80e-1264
hsa0414136EndometriumEECProtein processing in endoplasmic reticulum64/1237174/84652.17e-135.09e-123.80e-1264
hsa0414139EsophagusHGINProtein processing in endoplasmic reticulum67/1383174/84651.06e-122.16e-111.72e-1167
hsa04141114EsophagusHGINProtein processing in endoplasmic reticulum67/1383174/84651.06e-122.16e-111.72e-1167
hsa04141211EsophagusESCCProtein processing in endoplasmic reticulum147/4205174/84653.29e-221.10e-195.64e-20147
hsa04141310EsophagusESCCProtein processing in endoplasmic reticulum147/4205174/84653.29e-221.10e-195.64e-20147
hsa0414114LiverCirrhoticProtein processing in endoplasmic reticulum114/2530174/84651.16e-229.67e-215.96e-21114
hsa0414115LiverCirrhoticProtein processing in endoplasmic reticulum114/2530174/84651.16e-229.67e-215.96e-21114
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ERP29SNVMissense_Mutationrs755173279c.364N>Tp.Arg122Trpp.R122WP30040protein_codingtolerated(0.19)benign(0.003)TCGA-A8-A06R-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilCR
ERP29SNVMissense_Mutationc.200N>Ap.Gly67Aspp.G67DP30040protein_codingdeleterious(0)probably_damaging(0.998)TCGA-BH-A18U-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
ERP29deletionFrame_Shift_Delnovelc.476delCp.Pro159LeufsTer23p.P159Lfs*23P30040protein_codingTCGA-A7-A4SA-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinCR
ERP29insertionIn_Frame_Insnovelc.277_278insCTAGCTp.Ile93delinsThrSerPhep.I93delinsTSFP30040protein_codingTCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
ERP29insertionNonsense_Mutationnovelc.282_283insTACTAATGGp.Ser94_Asp95insTyrTerTrpp.S94_D95insY*WP30040protein_codingTCGA-BH-A0HK-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
ERP29SNVMissense_Mutationc.699N>Ap.Met233Ilep.M233IP30040protein_codingtolerated(0.41)benign(0.003)TCGA-DR-A0ZL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ERP29SNVMissense_Mutationrs201620890c.484N>Ap.Asp162Asnp.D162NP30040protein_codingdeleterious(0.01)benign(0.394)TCGA-EA-A3HS-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ERP29SNVMissense_Mutationc.549N>Cp.Gln183Hisp.Q183HP30040protein_codingdeleterious(0.02)benign(0.132)TCGA-IR-A3LK-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
ERP29SNVMissense_Mutationrs146674309c.358N>Tp.Leu120Phep.L120FP30040protein_codingdeleterious(0)possibly_damaging(0.814)TCGA-D5-6533-01Colorectumcolon adenocarcinomaFemale>=65I/IIChemotherapyoxaliplatinCR
ERP29SNVMissense_Mutationc.677N>Tp.Arg226Metp.R226MP30040protein_codingdeleterious(0.01)benign(0.398)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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