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Gene: EMC10 |
Gene summary for EMC10 |
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Gene information | Species | Human | Gene symbol | EMC10 | Gene ID | 284361 |
Gene name | ER membrane protein complex subunit 10 | |
Gene Alias | C19orf63 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q5UCC4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284361 | EMC10 | AEH-subject1 | Human | Endometrium | AEH | 9.77e-09 | -2.52e-01 | -0.3059 |
284361 | EMC10 | AEH-subject2 | Human | Endometrium | AEH | 5.29e-14 | -3.15e-01 | -0.2525 |
284361 | EMC10 | AEH-subject3 | Human | Endometrium | AEH | 2.84e-13 | -3.45e-01 | -0.2576 |
284361 | EMC10 | AEH-subject4 | Human | Endometrium | AEH | 1.01e-14 | -4.47e-01 | -0.2657 |
284361 | EMC10 | AEH-subject5 | Human | Endometrium | AEH | 4.56e-18 | -4.49e-01 | -0.2953 |
284361 | EMC10 | EEC-subject1 | Human | Endometrium | EEC | 1.28e-14 | -3.32e-01 | -0.2682 |
284361 | EMC10 | EEC-subject2 | Human | Endometrium | EEC | 5.85e-17 | -3.91e-01 | -0.2607 |
284361 | EMC10 | EEC-subject3 | Human | Endometrium | EEC | 1.64e-34 | -4.22e-01 | -0.2525 |
284361 | EMC10 | EEC-subject4 | Human | Endometrium | EEC | 1.53e-11 | -4.03e-01 | -0.2571 |
284361 | EMC10 | EEC-subject5 | Human | Endometrium | EEC | 1.46e-07 | -2.87e-01 | -0.249 |
284361 | EMC10 | GSM5276934 | Human | Endometrium | EEC | 7.12e-15 | -3.38e-01 | -0.0913 |
284361 | EMC10 | GSM5276937 | Human | Endometrium | EEC | 1.87e-15 | -4.21e-01 | -0.0897 |
284361 | EMC10 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.34e-32 | -3.04e-01 | -0.1869 |
284361 | EMC10 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.25e-32 | -2.28e-01 | -0.1875 |
284361 | EMC10 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.00e-39 | -1.79e-01 | -0.1883 |
284361 | EMC10 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.19e-30 | -1.24e-01 | -0.1934 |
284361 | EMC10 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.64e-47 | -2.00e-01 | -0.1917 |
284361 | EMC10 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 7.44e-50 | -2.28e-01 | -0.1916 |
284361 | EMC10 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.39e-04 | 1.05e-01 | -0.1269 |
284361 | EMC10 | LZE2T | Human | Esophagus | ESCC | 2.31e-04 | 8.59e-01 | 0.082 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090132111 | Thyroid | PTC | epithelium migration | 149/5968 | 360/18723 | 7.89e-05 | 6.74e-04 | 149 |
GO:00450485 | Thyroid | PTC | protein insertion into ER membrane | 16/5968 | 22/18723 | 9.98e-05 | 8.15e-04 | 16 |
GO:0090130111 | Thyroid | PTC | tissue migration | 150/5968 | 365/18723 | 1.13e-04 | 9.01e-04 | 150 |
GO:0010632111 | Thyroid | PTC | regulation of epithelial cell migration | 123/5968 | 292/18723 | 1.33e-04 | 1.05e-03 | 123 |
GO:001059516 | Thyroid | PTC | positive regulation of endothelial cell migration | 61/5968 | 133/18723 | 4.95e-04 | 3.25e-03 | 61 |
GO:0070302110 | Thyroid | PTC | regulation of stress-activated protein kinase signaling cascade | 83/5968 | 195/18723 | 1.04e-03 | 6.21e-03 | 83 |
GO:00718165 | Thyroid | PTC | tail-anchored membrane protein insertion into ER membrane | 12/5968 | 17/18723 | 1.20e-03 | 6.89e-03 | 12 |
GO:0032872110 | Thyroid | PTC | regulation of stress-activated MAPK cascade | 81/5968 | 192/18723 | 1.62e-03 | 8.95e-03 | 81 |
GO:004354219 | Thyroid | PTC | endothelial cell migration | 112/5968 | 279/18723 | 2.03e-03 | 1.09e-02 | 112 |
GO:00450505 | Thyroid | PTC | protein insertion into ER membrane by stop-transfer membrane-anchor sequence | 8/5968 | 10/18723 | 2.46e-03 | 1.27e-02 | 8 |
GO:004576612 | Thyroid | PTC | positive regulation of angiogenesis | 75/5968 | 181/18723 | 4.09e-03 | 1.95e-02 | 75 |
GO:190401812 | Thyroid | PTC | positive regulation of vasculature development | 75/5968 | 181/18723 | 4.09e-03 | 1.95e-02 | 75 |
GO:001059416 | Thyroid | PTC | regulation of endothelial cell migration | 91/5968 | 232/18723 | 1.03e-02 | 4.18e-02 | 91 |
GO:001059522 | Thyroid | goiters | positive regulation of endothelial cell migration | 15/497 | 133/18723 | 2.55e-06 | 1.27e-04 | 15 |
GO:001063426 | Thyroid | goiters | positive regulation of epithelial cell migration | 17/497 | 176/18723 | 4.76e-06 | 2.22e-04 | 17 |
GO:001059422 | Thyroid | goiters | regulation of endothelial cell migration | 18/497 | 232/18723 | 5.06e-05 | 1.73e-03 | 18 |
GO:004354223 | Thyroid | goiters | endothelial cell migration | 20/497 | 279/18723 | 6.02e-05 | 2.03e-03 | 20 |
GO:009015026 | Thyroid | goiters | establishment of protein localization to membrane | 19/497 | 260/18723 | 7.09e-05 | 2.37e-03 | 19 |
GO:001063225 | Thyroid | goiters | regulation of epithelial cell migration | 20/497 | 292/18723 | 1.13e-04 | 3.45e-03 | 20 |
GO:009013027 | Thyroid | goiters | tissue migration | 23/497 | 365/18723 | 1.25e-04 | 3.77e-03 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EMC10 | SNV | Missense_Mutation | novel | c.664N>C | p.Phe222Leu | p.F222L | Q5UCC4 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A8-A08G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
EMC10 | SNV | Missense_Mutation | rs369893864 | c.551N>T | p.Ser184Leu | p.S184L | Q5UCC4 | protein_coding | deleterious(0.01) | possibly_damaging(0.508) | TCGA-AR-A0TT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
EMC10 | SNV | Missense_Mutation | rs200217945 | c.610C>T | p.Arg204Cys | p.R204C | Q5UCC4 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EMC10 | SNV | Missense_Mutation | rs369893864 | c.551C>T | p.Ser184Leu | p.S184L | Q5UCC4 | protein_coding | deleterious(0.01) | possibly_damaging(0.508) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EMC10 | SNV | Missense_Mutation | novel | c.526N>A | p.Val176Met | p.V176M | Q5UCC4 | protein_coding | tolerated(0.1) | probably_damaging(0.916) | TCGA-VS-A9UB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EMC10 | SNV | Missense_Mutation | rs200217945 | c.610N>T | p.Arg204Cys | p.R204C | Q5UCC4 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
EMC10 | SNV | Missense_Mutation | c.487N>G | p.Thr163Ala | p.T163A | Q5UCC4 | protein_coding | tolerated(0.13) | benign(0.067) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EMC10 | deletion | Frame_Shift_Del | novel | c.578delN | p.Pro194GlnfsTer45 | p.P194Qfs*45 | Q5UCC4 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EMC10 | SNV | Missense_Mutation | novel | c.152C>T | p.Thr51Met | p.T51M | Q5UCC4 | protein_coding | tolerated(0.09) | possibly_damaging(0.556) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EMC10 | SNV | Missense_Mutation | novel | c.370G>A | p.Ala124Thr | p.A124T | Q5UCC4 | protein_coding | tolerated(0.37) | benign(0.012) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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