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Gene: EIF4EBP2 |
Gene summary for EIF4EBP2 |
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Gene information | Species | Human | Gene symbol | EIF4EBP2 | Gene ID | 1979 |
Gene name | eukaryotic translation initiation factor 4E binding protein 2 | |
Gene Alias | 4EBP2 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A024QZM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1979 | EIF4EBP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.71e-03 | 2.09e-01 | 0.0155 |
1979 | EIF4EBP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.73e-12 | 7.38e-01 | -0.1808 |
1979 | EIF4EBP2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.69e-08 | 5.66e-01 | -0.0811 |
1979 | EIF4EBP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.88e-24 | 9.05e-01 | -0.1088 |
1979 | EIF4EBP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.91e-39 | 9.61e-01 | -0.1954 |
1979 | EIF4EBP2 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.14e-10 | 1.30e+00 | -0.2602 |
1979 | EIF4EBP2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.63e-06 | 5.14e-01 | -0.1207 |
1979 | EIF4EBP2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.33e-06 | 5.45e-01 | -0.1526 |
1979 | EIF4EBP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.70e-09 | 4.49e-01 | -0.1464 |
1979 | EIF4EBP2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.51e-04 | 3.06e-01 | -0.1001 |
1979 | EIF4EBP2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.62e-12 | 5.82e-01 | -0.059 |
1979 | EIF4EBP2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.30e-09 | 7.96e-01 | -0.1706 |
1979 | EIF4EBP2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.90e-17 | 1.20e+00 | -0.2061 |
1979 | EIF4EBP2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.79e-02 | 7.04e-01 | -0.1462 |
1979 | EIF4EBP2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.24e-02 | 4.24e-01 | -0.0179 |
1979 | EIF4EBP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.54e-09 | 4.67e-01 | 0.096 |
1979 | EIF4EBP2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.04e-02 | 3.73e-01 | 0.0446 |
1979 | EIF4EBP2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 8.22e-06 | 7.30e-01 | 0.0131 |
1979 | EIF4EBP2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.16e-04 | 4.89e-01 | -0.0177 |
1979 | EIF4EBP2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.34e-04 | 6.75e-01 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003286923 | Thyroid | ATC | cellular response to insulin stimulus | 101/6293 | 203/18723 | 1.34e-06 | 1.69e-05 | 101 |
GO:000828618 | Thyroid | ATC | insulin receptor signaling pathway | 60/6293 | 116/18723 | 4.20e-05 | 3.40e-04 | 60 |
GO:003424923 | Thyroid | ATC | negative regulation of cellular amide metabolic process | 121/6293 | 273/18723 | 1.36e-04 | 9.57e-04 | 121 |
GO:004594722 | Thyroid | ATC | negative regulation of translational initiation | 14/6293 | 19/18723 | 4.17e-04 | 2.50e-03 | 14 |
GO:001714823 | Thyroid | ATC | negative regulation of translation | 107/6293 | 245/18723 | 6.17e-04 | 3.51e-03 | 107 |
GO:003192911 | Thyroid | ATC | TOR signaling | 59/6293 | 126/18723 | 1.39e-03 | 7.19e-03 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04213 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa042131 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa042132 | Colorectum | SER | Longevity regulating pathway - multiple species | 20/1580 | 62/8465 | 7.15e-03 | 3.77e-02 | 2.74e-02 | 20 |
hsa042133 | Colorectum | SER | Longevity regulating pathway - multiple species | 20/1580 | 62/8465 | 7.15e-03 | 3.77e-02 | 2.74e-02 | 20 |
hsa042134 | Colorectum | MSS | Longevity regulating pathway - multiple species | 27/1875 | 62/8465 | 1.33e-04 | 1.17e-03 | 7.18e-04 | 27 |
hsa042135 | Colorectum | MSS | Longevity regulating pathway - multiple species | 27/1875 | 62/8465 | 1.33e-04 | 1.17e-03 | 7.18e-04 | 27 |
hsa042138 | Liver | HCC | Longevity regulating pathway - multiple species | 41/4020 | 62/8465 | 2.30e-03 | 7.86e-03 | 4.37e-03 | 41 |
hsa0421311 | Liver | HCC | Longevity regulating pathway - multiple species | 41/4020 | 62/8465 | 2.30e-03 | 7.86e-03 | 4.37e-03 | 41 |
hsa0421310 | Oral cavity | OSCC | Longevity regulating pathway - multiple species | 38/3704 | 62/8465 | 3.97e-03 | 9.86e-03 | 5.02e-03 | 38 |
hsa0421313 | Oral cavity | OSCC | Longevity regulating pathway - multiple species | 38/3704 | 62/8465 | 3.97e-03 | 9.86e-03 | 5.02e-03 | 38 |
hsa042139 | Prostate | BPH | Longevity regulating pathway - multiple species | 20/1718 | 62/8465 | 1.78e-02 | 4.98e-02 | 3.08e-02 | 20 |
hsa0421312 | Prostate | BPH | Longevity regulating pathway - multiple species | 20/1718 | 62/8465 | 1.78e-02 | 4.98e-02 | 3.08e-02 | 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF4EBP2 | SNV | Missense_Mutation | c.163N>T | p.Asp55Tyr | p.D55Y | Q13542 | protein_coding | deleterious(0) | possibly_damaging(0.761) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
EIF4EBP2 | SNV | Missense_Mutation | rs201115758 | c.152N>A | p.Arg51Gln | p.R51Q | Q13542 | protein_coding | deleterious(0.02) | benign(0.038) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF4EBP2 | insertion | Frame_Shift_Ins | novel | c.351_352insC | p.Met118HisfsTer17 | p.M118Hfs*17 | Q13542 | protein_coding | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EIF4EBP2 | insertion | Nonsense_Mutation | novel | c.352_353insAATAGACCTTGTTTCTTTTGTTTTGTTT | p.Met118LysfsTer2 | p.M118Kfs*2 | Q13542 | protein_coding | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EIF4EBP2 | SNV | Missense_Mutation | novel | c.194N>A | p.Ser65Tyr | p.S65Y | Q13542 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
EIF4EBP2 | SNV | Missense_Mutation | c.185N>C | p.Arg62Pro | p.R62P | Q13542 | protein_coding | deleterious(0.03) | possibly_damaging(0.856) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
EIF4EBP2 | SNV | Missense_Mutation | c.277N>T | p.Val93Leu | p.V93L | Q13542 | protein_coding | tolerated(0.34) | benign(0.171) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EIF4EBP2 | insertion | Frame_Shift_Ins | rs751644163 | c.114_115insG | p.Thr41AspfsTer15 | p.T41Dfs*15 | Q13542 | protein_coding | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | ||
EIF4EBP2 | SNV | Missense_Mutation | rs750591080 | c.188N>A | p.Arg63His | p.R63H | Q13542 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EIF4EBP2 | SNV | Missense_Mutation | rs750591080 | c.188N>A | p.Arg63His | p.R63H | Q13542 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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