Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/DUSP1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/DUSP1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/DUSP1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/DUSP1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/DUSP1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DUSP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/DUSP1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DUSP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/DUSP1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DUSP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/DUSP1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/DUSP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DUSP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005092011 | Cervix | HSIL_HPV | regulation of chemotaxis | 21/737 | 223/18723 | 2.05e-04 | 3.70e-03 | 21 |
GO:005138414 | Cervix | HSIL_HPV | response to glucocorticoid | 15/737 | 148/18723 | 7.50e-04 | 9.99e-03 | 15 |
GO:00017041 | Cervix | HSIL_HPV | formation of primary germ layer | 13/737 | 121/18723 | 9.63e-04 | 1.20e-02 | 13 |
GO:005159115 | Cervix | HSIL_HPV | response to cAMP | 11/737 | 93/18723 | 1.06e-03 | 1.30e-02 | 11 |
GO:007037112 | Cervix | HSIL_HPV | ERK1 and ERK2 cascade | 25/737 | 330/18723 | 1.42e-03 | 1.59e-02 | 25 |
GO:004668310 | Cervix | HSIL_HPV | response to organophosphorus | 13/737 | 131/18723 | 1.99e-03 | 2.08e-02 | 13 |
GO:004340913 | Cervix | HSIL_HPV | negative regulation of MAPK cascade | 16/737 | 180/18723 | 2.05e-03 | 2.13e-02 | 16 |
GO:005159214 | Cervix | HSIL_HPV | response to calcium ion | 14/737 | 149/18723 | 2.29e-03 | 2.28e-02 | 14 |
GO:003210211 | Cervix | HSIL_HPV | negative regulation of response to external stimulus | 29/737 | 420/18723 | 2.53e-03 | 2.48e-02 | 29 |
GO:007037211 | Cervix | HSIL_HPV | regulation of ERK1 and ERK2 cascade | 23/737 | 309/18723 | 2.70e-03 | 2.58e-02 | 23 |
GO:000736911 | Cervix | HSIL_HPV | gastrulation | 16/737 | 185/18723 | 2.71e-03 | 2.58e-02 | 16 |
GO:003287314 | Cervix | HSIL_HPV | negative regulation of stress-activated MAPK cascade | 7/737 | 51/18723 | 3.65e-03 | 3.25e-02 | 7 |
GO:007030314 | Cervix | HSIL_HPV | negative regulation of stress-activated protein kinase signaling cascade | 7/737 | 51/18723 | 3.65e-03 | 3.25e-02 | 7 |
GO:0001706 | Cervix | HSIL_HPV | endoderm formation | 7/737 | 54/18723 | 5.04e-03 | 4.12e-02 | 7 |
GO:009002511 | Cervix | HSIL_HPV | regulation of monocyte chemotaxis | 5/737 | 29/18723 | 5.05e-03 | 4.12e-02 | 5 |
GO:001407410 | Cervix | HSIL_HPV | response to purine-containing compound | 13/737 | 148/18723 | 5.72e-03 | 4.55e-02 | 13 |
GO:000254812 | Cervix | HSIL_HPV | monocyte chemotaxis | 8/737 | 70/18723 | 6.09e-03 | 4.77e-02 | 8 |
GO:009752922 | Cervix | N_HPV | myeloid leukocyte migration | 24/534 | 220/18723 | 2.01e-08 | 2.87e-06 | 24 |
GO:000268522 | Cervix | N_HPV | regulation of leukocyte migration | 23/534 | 210/18723 | 3.69e-08 | 4.31e-06 | 23 |
GO:007167522 | Cervix | N_HPV | regulation of mononuclear cell migration | 16/534 | 115/18723 | 1.70e-07 | 1.43e-05 | 16 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUSP1 | SNV | Missense_Mutation | | c.595N>A | p.Gly199Ser | p.G199S | P28562 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DUSP1 | insertion | In_Frame_Ins | novel | c.995_996insATC | p.Gly332_Thr333insSer | p.G332_T333insS | P28562 | protein_coding | | | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
DUSP1 | insertion | Frame_Shift_Ins | novel | c.994_995insTCCATCTGACAAAATGGGGCAGAAGAGAAAGGACTCAGTGTGT | p.Gly332ValfsTer57 | p.G332Vfs*57 | P28562 | protein_coding | | | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
DUSP1 | insertion | Nonsense_Mutation | novel | c.848_849insTTTAACTTCACCCGAGTTCCTCTGGGTTTCTAAGCAGTTATGGTGAT | p.Glu283AspfsTer16 | p.E283Dfs*16 | P28562 | protein_coding | | | TCGA-B6-A0IM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DUSP1 | insertion | Frame_Shift_Ins | novel | c.665_666insGCACCTCCACCACCACCGTGTTCAACTTCCCCGTCTC | p.Ser222ArgfsTer33 | p.S222Rfs*33 | P28562 | protein_coding | | | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DUSP1 | insertion | Frame_Shift_Ins | novel | c.848_849insAAGGACTCAGTGTGTGATCCGGTTTCTT | p.Ala284ArgfsTer12 | p.A284Rfs*12 | P28562 | protein_coding | | | TCGA-BH-A0BV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD |
DUSP1 | SNV | Missense_Mutation | | c.609G>C | p.Leu203Phe | p.L203F | P28562 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
DUSP1 | SNV | Missense_Mutation | novel | c.376N>C | p.Glu126Gln | p.E126Q | P28562 | protein_coding | tolerated(0.05) | possibly_damaging(0.565) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DUSP1 | SNV | Missense_Mutation | | c.565N>A | p.Ala189Thr | p.A189T | P28562 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
DUSP1 | SNV | Missense_Mutation | | c.1056N>A | p.Ser352Arg | p.S352R | P28562 | protein_coding | deleterious(0.02) | benign(0.221) | TCGA-AP-A0LH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | | Avastin+/-Tarceva | | |
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | | HYDROXYUREA | HYDROXYUREA | 15856297 |
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | | salbutamol | ALBUTEROL | 20673984 |
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | | VASOPRESSIN | VASOPRESSIN | 9231829 |
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | | ANTISENSE OLIGONUCLEOTIDES | | 11988488 |