Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00975303 | Stomach | CAG | granulocyte migration | 12/552 | 148/18723 | 1.48e-03 | 1.83e-02 | 12 |
GO:00712193 | Stomach | CAG | cellular response to molecule of bacterial origin | 15/552 | 221/18723 | 2.41e-03 | 2.61e-02 | 15 |
GO:00712163 | Stomach | CAG | cellular response to biotic stimulus | 16/552 | 246/18723 | 2.70e-03 | 2.77e-02 | 16 |
GO:00305933 | Stomach | CAG | neutrophil chemotaxis | 9/552 | 103/18723 | 3.40e-03 | 3.26e-02 | 9 |
GO:0019221 | Stomach | CAG | cytokine-mediated signaling pathway | 25/552 | 472/18723 | 3.63e-03 | 3.38e-02 | 25 |
GO:00197304 | Stomach | WIM | antimicrobial humoral response | 16/426 | 122/18723 | 1.77e-08 | 2.26e-06 | 16 |
GO:00618444 | Stomach | WIM | antimicrobial humoral immune response mediated by antimicrobial peptide | 12/426 | 79/18723 | 2.13e-07 | 1.88e-05 | 12 |
GO:00022374 | Stomach | WIM | response to molecule of bacterial origin | 25/426 | 363/18723 | 9.89e-07 | 7.03e-05 | 25 |
GO:00716214 | Stomach | WIM | granulocyte chemotaxis | 14/426 | 125/18723 | 9.93e-07 | 7.03e-05 | 14 |
GO:00305954 | Stomach | WIM | leukocyte chemotaxis | 18/426 | 230/18723 | 5.77e-06 | 2.93e-04 | 18 |
GO:00975304 | Stomach | WIM | granulocyte migration | 14/426 | 148/18723 | 7.42e-06 | 3.63e-04 | 14 |
GO:00975294 | Stomach | WIM | myeloid leukocyte migration | 17/426 | 220/18723 | 1.24e-05 | 5.57e-04 | 17 |
GO:00324964 | Stomach | WIM | response to lipopolysaccharide | 22/426 | 343/18723 | 1.37e-05 | 6.02e-04 | 22 |
GO:00305934 | Stomach | WIM | neutrophil chemotaxis | 11/426 | 103/18723 | 2.27e-05 | 8.72e-04 | 11 |
GO:00603264 | Stomach | WIM | cell chemotaxis | 20/426 | 310/18723 | 3.09e-05 | 1.10e-03 | 20 |
GO:00192211 | Stomach | WIM | cytokine-mediated signaling pathway | 26/426 | 472/18723 | 3.31e-05 | 1.16e-03 | 26 |
GO:00509004 | Stomach | WIM | leukocyte migration | 22/426 | 369/18723 | 4.17e-05 | 1.35e-03 | 22 |
GO:00069594 | Stomach | WIM | humoral immune response | 20/426 | 317/18723 | 4.23e-05 | 1.35e-03 | 20 |
GO:00712224 | Stomach | WIM | cellular response to lipopolysaccharide | 15/426 | 209/18723 | 9.26e-05 | 2.55e-03 | 15 |
GO:19902663 | Stomach | WIM | neutrophil migration | 11/426 | 122/18723 | 1.08e-04 | 2.92e-03 | 11 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513414 | Breast | Precancer | Legionellosis | 19/684 | 57/8465 | 4.62e-08 | 9.12e-07 | 6.98e-07 | 19 |
hsa0516718 | Breast | Precancer | Kaposi sarcoma-associated herpesvirus infection | 36/684 | 194/8465 | 1.68e-06 | 2.53e-05 | 1.94e-05 | 36 |
hsa0541718 | Breast | Precancer | Lipid and atherosclerosis | 37/684 | 215/8465 | 7.64e-06 | 9.29e-05 | 7.12e-05 | 37 |
hsa0465716 | Breast | Precancer | IL-17 signaling pathway | 20/684 | 94/8465 | 4.74e-05 | 4.54e-04 | 3.48e-04 | 20 |
hsa0532312 | Breast | Precancer | Rheumatoid arthritis | 19/684 | 93/8465 | 1.30e-04 | 1.14e-03 | 8.73e-04 | 19 |
hsa051206 | Breast | Precancer | Epithelial cell signaling in Helicobacter pylori infection | 14/684 | 70/8465 | 1.21e-03 | 7.99e-03 | 6.12e-03 | 14 |
hsa0513415 | Breast | Precancer | Legionellosis | 19/684 | 57/8465 | 4.62e-08 | 9.12e-07 | 6.98e-07 | 19 |
hsa0516719 | Breast | Precancer | Kaposi sarcoma-associated herpesvirus infection | 36/684 | 194/8465 | 1.68e-06 | 2.53e-05 | 1.94e-05 | 36 |
hsa0541719 | Breast | Precancer | Lipid and atherosclerosis | 37/684 | 215/8465 | 7.64e-06 | 9.29e-05 | 7.12e-05 | 37 |
hsa0465717 | Breast | Precancer | IL-17 signaling pathway | 20/684 | 94/8465 | 4.74e-05 | 4.54e-04 | 3.48e-04 | 20 |
hsa0532313 | Breast | Precancer | Rheumatoid arthritis | 19/684 | 93/8465 | 1.30e-04 | 1.14e-03 | 8.73e-04 | 19 |
hsa0512013 | Breast | Precancer | Epithelial cell signaling in Helicobacter pylori infection | 14/684 | 70/8465 | 1.21e-03 | 7.99e-03 | 6.12e-03 | 14 |
hsa0513422 | Breast | IDC | Legionellosis | 19/867 | 57/8465 | 1.89e-06 | 3.07e-05 | 2.29e-05 | 19 |
hsa0516723 | Breast | IDC | Kaposi sarcoma-associated herpesvirus infection | 38/867 | 194/8465 | 5.87e-05 | 5.96e-04 | 4.46e-04 | 38 |
hsa0532321 | Breast | IDC | Rheumatoid arthritis | 21/867 | 93/8465 | 3.69e-04 | 3.15e-03 | 2.36e-03 | 21 |
hsa0512022 | Breast | IDC | Epithelial cell signaling in Helicobacter pylori infection | 16/867 | 70/8465 | 1.56e-03 | 1.13e-02 | 8.42e-03 | 16 |
hsa0541724 | Breast | IDC | Lipid and atherosclerosis | 35/867 | 215/8465 | 3.67e-03 | 2.29e-02 | 1.71e-02 | 35 |
hsa0465721 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0513432 | Breast | IDC | Legionellosis | 19/867 | 57/8465 | 1.89e-06 | 3.07e-05 | 2.29e-05 | 19 |
hsa0516733 | Breast | IDC | Kaposi sarcoma-associated herpesvirus infection | 38/867 | 194/8465 | 5.87e-05 | 5.96e-04 | 4.46e-04 | 38 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CXCL2 | SNV | Missense_Mutation | novel | c.217G>A | p.Glu73Lys | p.E73K | P19875 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CXCL2 | SNV | Missense_Mutation | | c.16N>T | p.Leu6Phe | p.L6F | P19875 | protein_coding | tolerated_low_confidence(0.4) | benign(0.346) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
CXCL2 | SNV | Missense_Mutation | novel | c.297N>T | p.Lys99Asn | p.K99N | P19875 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CXCL2 | SNV | Missense_Mutation | novel | c.217N>A | p.Glu73Lys | p.E73K | P19875 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CXCL2 | SNV | Missense_Mutation | rs758440195 | c.149N>G | p.Gln50Arg | p.Q50R | P19875 | protein_coding | tolerated(0.18) | benign(0.026) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CXCL2 | SNV | Missense_Mutation | rs755316953 | c.165G>T | p.Lys55Asn | p.K55N | P19875 | protein_coding | deleterious(0.03) | probably_damaging(0.982) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
CXCL2 | SNV | Missense_Mutation | | c.292G>A | p.Glu98Lys | p.E98K | P19875 | protein_coding | tolerated(0.09) | benign(0.009) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CXCL2 | SNV | Missense_Mutation | novel | c.208N>A | p.Ala70Thr | p.A70T | P19875 | protein_coding | tolerated(0.55) | benign(0.027) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CXCL2 | SNV | Missense_Mutation | novel | c.121C>A | p.Leu41Met | p.L41M | P19875 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CXCL2 | insertion | Frame_Shift_Ins | novel | c.202dupC | p.His68ProfsTer27 | p.H68Pfs*27 | P19875 | protein_coding | | | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |