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Gene: CFL1 |
Gene summary for CFL1 |
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Gene information | Species | Human | Gene symbol | CFL1 | Gene ID | 1072 |
Gene name | cofilin 1 | |
Gene Alias | CFL | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P23528 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1072 | CFL1 | CA_HPV_1 | Human | Cervix | CC | 6.93e-16 | 1.85e-01 | 0.0264 |
1072 | CFL1 | CA_HPV_3 | Human | Cervix | CC | 4.60e-02 | 5.68e-02 | 0.0414 |
1072 | CFL1 | N_HPV_1 | Human | Cervix | N_HPV | 1.23e-04 | 1.77e-01 | 0.0079 |
1072 | CFL1 | N_HPV_2 | Human | Cervix | N_HPV | 2.75e-03 | 2.35e-01 | -0.0131 |
1072 | CFL1 | CCI_1 | Human | Cervix | CC | 7.77e-25 | -1.21e+00 | 0.528 |
1072 | CFL1 | CCI_2 | Human | Cervix | CC | 2.09e-02 | -2.01e-01 | 0.5249 |
1072 | CFL1 | CCI_3 | Human | Cervix | CC | 1.94e-27 | -1.12e+00 | 0.516 |
1072 | CFL1 | CCII_1 | Human | Cervix | CC | 2.13e-45 | -1.25e+00 | 0.3249 |
1072 | CFL1 | Tumor | Human | Cervix | CC | 9.03e-09 | 2.88e-01 | 0.1241 |
1072 | CFL1 | sample1 | Human | Cervix | CC | 5.76e-03 | 2.83e-01 | 0.0959 |
1072 | CFL1 | sample3 | Human | Cervix | CC | 1.28e-07 | 2.49e-01 | 0.1387 |
1072 | CFL1 | H2 | Human | Cervix | HSIL_HPV | 6.31e-04 | -2.79e-01 | 0.0632 |
1072 | CFL1 | L1 | Human | Cervix | CC | 4.84e-05 | 1.38e-01 | 0.0802 |
1072 | CFL1 | T3 | Human | Cervix | CC | 2.73e-03 | 2.55e-01 | 0.1389 |
1072 | CFL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.52e-97 | 2.03e+00 | 0.0155 |
1072 | CFL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.56e-75 | 3.79e+00 | -0.1808 |
1072 | CFL1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.06e-26 | 2.33e+00 | 0.0216 |
1072 | CFL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.65e-65 | 3.50e+00 | -0.0811 |
1072 | CFL1 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.63e-65 | 2.28e+00 | -0.1088 |
1072 | CFL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.76e-121 | 3.33e+00 | -0.1954 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00358219 | Esophagus | HGIN | modulation of process of other organism | 27/2587 | 106/18723 | 9.89e-04 | 1.24e-02 | 27 |
GO:005170210 | Esophagus | HGIN | biological process involved in interaction with symbiont | 24/2587 | 94/18723 | 1.78e-03 | 1.92e-02 | 24 |
GO:000961517 | Esophagus | HGIN | response to virus | 69/2587 | 367/18723 | 4.39e-03 | 3.86e-02 | 69 |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:0044403111 | Esophagus | ESCC | biological process involved in symbiotic interaction | 186/8552 | 290/18723 | 1.43e-10 | 4.16e-09 | 186 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
GO:000815420 | Esophagus | ESCC | actin polymerization or depolymerization | 130/8552 | 218/18723 | 2.19e-05 | 1.88e-04 | 130 |
GO:005185115 | Esophagus | ESCC | modulation by host of symbiont process | 43/8552 | 60/18723 | 4.00e-05 | 3.22e-04 | 43 |
GO:005181714 | Esophagus | ESCC | modulation of process of other organism involved in symbiotic interaction | 54/8552 | 81/18723 | 1.09e-04 | 7.64e-04 | 54 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:004479415 | Esophagus | ESCC | positive regulation by host of viral process | 12/8552 | 13/18723 | 6.18e-04 | 3.32e-03 | 12 |
GO:000726610 | Esophagus | ESCC | Rho protein signal transduction | 81/8552 | 137/18723 | 1.03e-03 | 5.20e-03 | 81 |
GO:003582114 | Esophagus | ESCC | modulation of process of other organism | 64/8552 | 106/18723 | 1.61e-03 | 7.50e-03 | 64 |
GO:00516533 | Esophagus | ESCC | spindle localization | 37/8552 | 56/18723 | 1.65e-03 | 7.65e-03 | 37 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0466612 | Cervix | CC | Fc gamma R-mediated phagocytosis | 31/1267 | 97/8465 | 1.78e-05 | 1.42e-04 | 8.40e-05 | 31 |
hsa0517016 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa043609 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa051337 | Cervix | CC | Pertussis | 21/1267 | 76/8465 | 3.08e-03 | 1.19e-02 | 7.03e-03 | 21 |
hsa0481017 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0466613 | Cervix | CC | Fc gamma R-mediated phagocytosis | 31/1267 | 97/8465 | 1.78e-05 | 1.42e-04 | 8.40e-05 | 31 |
hsa0517017 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa0436012 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa0513312 | Cervix | CC | Pertussis | 21/1267 | 76/8465 | 3.08e-03 | 1.19e-02 | 7.03e-03 | 21 |
hsa0513321 | Cervix | HSIL_HPV | Pertussis | 10/459 | 76/8465 | 7.61e-03 | 4.37e-02 | 3.53e-02 | 10 |
hsa0513331 | Cervix | HSIL_HPV | Pertussis | 10/459 | 76/8465 | 7.61e-03 | 4.37e-02 | 3.53e-02 | 10 |
hsa0513341 | Cervix | N_HPV | Pertussis | 9/349 | 76/8465 | 3.86e-03 | 2.10e-02 | 1.64e-02 | 9 |
hsa0513351 | Cervix | N_HPV | Pertussis | 9/349 | 76/8465 | 3.86e-03 | 2.10e-02 | 1.64e-02 | 9 |
hsa04666 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa04360 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa046661 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFL1 | insertion | Nonsense_Mutation | novel | c.9_10insTAGGCCTCC | p.Ser3_Gly4insTer | p.S3_G4ins* | P23528 | protein_coding | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |||
CFL1 | SNV | Missense_Mutation | novel | c.25N>A | p.Asp9Asn | p.D9N | P23528 | protein_coding | deleterious(0) | benign(0.089) | TCGA-C5-A7UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CFL1 | SNV | Missense_Mutation | novel | c.95N>A | p.Arg32His | p.R32H | P23528 | protein_coding | tolerated(0.14) | benign(0.237) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFL1 | SNV | Missense_Mutation | c.283A>C | p.Lys95Gln | p.K95Q | P23528 | protein_coding | deleterious(0.04) | benign(0.055) | TCGA-AA-A00O-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CFL1 | SNV | Missense_Mutation | c.472N>A | p.Val158Ile | p.V158I | P23528 | protein_coding | tolerated(0.42) | benign(0.03) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CFL1 | SNV | Missense_Mutation | c.247N>A | p.Ala83Thr | p.A83T | P23528 | protein_coding | tolerated(0.07) | benign(0.103) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CFL1 | SNV | Missense_Mutation | novel | c.104N>T | p.Ala35Val | p.A35V | P23528 | protein_coding | tolerated(0.06) | benign(0.046) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CFL1 | SNV | Missense_Mutation | c.336G>C | p.Lys112Asn | p.K112N | P23528 | protein_coding | deleterious(0.02) | possibly_damaging(0.885) | TCGA-AX-A2H2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CFL1 | SNV | Missense_Mutation | novel | c.94C>T | p.Arg32Cys | p.R32C | P23528 | protein_coding | tolerated(0.08) | possibly_damaging(0.515) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFL1 | SNV | Missense_Mutation | c.52N>T | p.Met18Leu | p.M18L | P23528 | protein_coding | tolerated(0.11) | benign(0.173) | TCGA-ED-A7XP-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1072 | CFL1 | KINASE | SERTRALINE | SERTRALINE | 16680159 | |
1072 | CFL1 | KINASE | ROTENONE | ROTENONE | 16680159 | |
1072 | CFL1 | KINASE | CLOTRIMAZOLE | CLOTRIMAZOLE | 16680159 | |
1072 | CFL1 | KINASE | FENOFIBRATE | FENOFIBRATE | 16680159 | |
1072 | CFL1 | KINASE | PATULIN | PATULIN | 16680159 | |
1072 | CFL1 | KINASE | CLOFIBRATE | CLOFIBRATE | 16680159 | |
1072 | CFL1 | KINASE | MG-132 | MG-132 | 16680159 | |
1072 | CFL1 | KINASE | CINNARIZINE | CINNARIZINE | 16680159 |
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