Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000038015 | Prostate | Tumor | alternative mRNA splicing, via spliceosome | 35/3246 | 77/18723 | 9.41e-09 | 3.55e-07 | 35 |
GO:000734613 | Prostate | Tumor | regulation of mitotic cell cycle | 113/3246 | 457/18723 | 3.37e-05 | 3.96e-04 | 113 |
GO:000635412 | Prostate | Tumor | DNA-templated transcription, elongation | 31/3246 | 91/18723 | 8.58e-05 | 8.53e-04 | 31 |
GO:000636812 | Prostate | Tumor | transcription elongation from RNA polymerase II promoter | 25/3246 | 69/18723 | 1.33e-04 | 1.23e-03 | 25 |
GO:200073712 | Prostate | Tumor | negative regulation of stem cell differentiation | 12/3246 | 23/18723 | 1.47e-04 | 1.33e-03 | 12 |
GO:200073612 | Prostate | Tumor | regulation of stem cell differentiation | 21/3246 | 58/18723 | 4.52e-04 | 3.42e-03 | 21 |
GO:004886315 | Prostate | Tumor | stem cell differentiation | 55/3246 | 206/18723 | 4.81e-04 | 3.57e-03 | 55 |
GO:003278611 | Prostate | Tumor | positive regulation of DNA-templated transcription, elongation | 12/3246 | 27/18723 | 9.52e-04 | 6.20e-03 | 12 |
GO:00327841 | Prostate | Tumor | regulation of DNA-templated transcription, elongation | 18/3246 | 53/18723 | 2.59e-03 | 1.43e-02 | 18 |
GO:00342431 | Prostate | Tumor | regulation of transcription elongation from RNA polymerase II promoter | 12/3246 | 32/18723 | 5.30e-03 | 2.54e-02 | 12 |
GO:014001412 | Prostate | Tumor | mitotic nuclear division | 66/3246 | 287/18723 | 8.19e-03 | 3.60e-02 | 66 |
GO:000838027 | Skin | AK | RNA splicing | 111/1910 | 434/18723 | 1.85e-20 | 5.49e-17 | 111 |
GO:000037526 | Skin | AK | RNA splicing, via transesterification reactions | 85/1910 | 324/18723 | 1.16e-16 | 7.62e-14 | 85 |
GO:000037726 | Skin | AK | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 84/1910 | 320/18723 | 1.69e-16 | 9.11e-14 | 84 |
GO:000039826 | Skin | AK | mRNA splicing, via spliceosome | 84/1910 | 320/18723 | 1.69e-16 | 9.11e-14 | 84 |
GO:000038020 | Skin | AK | alternative mRNA splicing, via spliceosome | 30/1910 | 77/18723 | 2.57e-11 | 4.90e-09 | 30 |
GO:000734616 | Skin | AK | regulation of mitotic cell cycle | 87/1910 | 457/18723 | 6.50e-09 | 4.47e-07 | 87 |
GO:00329686 | Skin | AK | positive regulation of transcription elongation from RNA polymerase II promoter | 9/1910 | 13/18723 | 5.74e-07 | 2.03e-05 | 9 |
GO:00063549 | Skin | AK | DNA-templated transcription, elongation | 25/1910 | 91/18723 | 2.82e-06 | 7.60e-05 | 25 |
GO:00327867 | Skin | AK | positive regulation of DNA-templated transcription, elongation | 12/1910 | 27/18723 | 4.93e-06 | 1.16e-04 | 12 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDK13 | SNV | Missense_Mutation | | c.1738N>G | p.Leu580Val | p.L580V | Q14004 | protein_coding | tolerated(0.95) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CDK13 | SNV | Missense_Mutation | | c.2522N>T | p.Ser841Phe | p.S841F | Q14004 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CDK13 | SNV | Missense_Mutation | | c.2045N>A | p.Ile682Lys | p.I682K | Q14004 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CDK13 | SNV | Missense_Mutation | | c.2866N>C | p.Tyr956His | p.Y956H | Q14004 | protein_coding | tolerated(0.1) | possibly_damaging(0.673) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDK13 | SNV | Missense_Mutation | | c.1865N>T | p.Ala622Val | p.A622V | Q14004 | protein_coding | tolerated(0.42) | benign(0.025) | TCGA-D8-A1XC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CDK13 | SNV | Missense_Mutation | novel | c.3716N>G | p.Asp1239Gly | p.D1239G | Q14004 | protein_coding | deleterious_low_confidence(0.02) | benign(0.154) | TCGA-GM-A3XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
CDK13 | SNV | Missense_Mutation | novel | c.3806C>T | p.Pro1269Leu | p.P1269L | Q14004 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.923) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
CDK13 | SNV | Missense_Mutation | novel | c.2159N>G | p.Tyr720Cys | p.Y720C | Q14004 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
CDK13 | insertion | In_Frame_Ins | novel | c.1809_1810insGTCTGGAAA | p.Val603_Thr604insValTrpLys | p.V603_T604insVWK | Q14004 | protein_coding | | | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
CDK13 | insertion | Frame_Shift_Ins | novel | c.3817_3818insTAAATGTCTCCAT | p.Glu1273ValfsTer25 | p.E1273Vfs*25 | Q14004 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | 375973251 | | |
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL3544942 | RONICICLIB | |
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL488436 | AZD-5438 | |
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL445813 | AT-7519 | |
8621 | CDK13 | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL1230607 | PHA-793887 | |