Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/BCL6_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/BCL6_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/BCL6_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00508636 | Lung | IAC | regulation of T cell activation | 54/2061 | 329/18723 | 1.77e-03 | 1.82e-02 | 54 |
GO:19031311 | Lung | IAC | mononuclear cell differentiation | 66/2061 | 426/18723 | 2.63e-03 | 2.44e-02 | 66 |
GO:19030376 | Lung | IAC | regulation of leukocyte cell-cell adhesion | 54/2061 | 336/18723 | 2.82e-03 | 2.55e-02 | 54 |
GO:00085932 | Lung | IAC | regulation of Notch signaling pathway | 20/2061 | 95/18723 | 3.15e-03 | 2.75e-02 | 20 |
GO:00903112 | Lung | IAC | regulation of protein deacetylation | 12/2061 | 48/18723 | 4.87e-03 | 3.77e-02 | 12 |
GO:0090398 | Lung | IAC | cellular senescence | 19/2061 | 93/18723 | 5.56e-03 | 4.12e-02 | 19 |
GO:0090342 | Lung | IAC | regulation of cell aging | 14/2061 | 61/18723 | 5.64e-03 | 4.14e-02 | 14 |
GO:00465803 | Lung | IAC | negative regulation of Ras protein signal transduction | 12/2061 | 49/18723 | 5.82e-03 | 4.23e-02 | 12 |
GO:0010812 | Lung | IAC | negative regulation of cell-substrate adhesion | 15/2061 | 68/18723 | 6.28e-03 | 4.49e-02 | 15 |
GO:00510527 | Lung | IAC | regulation of DNA metabolic process | 55/2061 | 359/18723 | 7.12e-03 | 4.87e-02 | 55 |
GO:19037068 | Lung | IAC | regulation of hemopoiesis | 56/2061 | 367/18723 | 7.23e-03 | 4.94e-02 | 56 |
GO:000716012 | Lung | AIS | cell-matrix adhesion | 60/1849 | 233/18723 | 2.19e-12 | 2.55e-09 | 60 |
GO:003158913 | Lung | AIS | cell-substrate adhesion | 80/1849 | 363/18723 | 3.80e-12 | 3.16e-09 | 80 |
GO:001081013 | Lung | AIS | regulation of cell-substrate adhesion | 55/1849 | 221/18723 | 7.48e-11 | 2.49e-08 | 55 |
GO:000195212 | Lung | AIS | regulation of cell-matrix adhesion | 38/1849 | 128/18723 | 2.93e-10 | 7.42e-08 | 38 |
GO:005105611 | Lung | AIS | regulation of small GTPase mediated signal transduction | 66/1849 | 302/18723 | 4.26e-10 | 9.53e-08 | 66 |
GO:001657012 | Lung | AIS | histone modification | 81/1849 | 463/18723 | 2.30e-07 | 2.16e-05 | 81 |
GO:001604912 | Lung | AIS | cell growth | 83/1849 | 482/18723 | 3.26e-07 | 2.79e-05 | 83 |
GO:004308711 | Lung | AIS | regulation of GTPase activity | 65/1849 | 348/18723 | 3.35e-07 | 2.83e-05 | 65 |
GO:004578513 | Lung | AIS | positive regulation of cell adhesion | 77/1849 | 437/18723 | 3.40e-07 | 2.83e-05 | 77 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
BCL6 | CD8TEXINT | Breast | ADJ | LPP,SSH1,C11orf54, etc. | 8.23e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
BCL6 | GC | Breast | DCIS | LPP,SSH1,C11orf54, etc. | 2.50e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_DCIS/regulons_activity_in_dotplot.png) |
BCL6 | GC | Breast | IDC | LPP,SSH1,C11orf54, etc. | 1.81e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_IDC/regulons_activity_in_dotplot.png) |
BCL6 | CT | Colorectum | CRC | AC023590.1,TSC22D3,DNAJA1, etc. | 2.75e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_CRC/regulons_activity_in_dotplot.png) |
BCL6 | CT | Colorectum | FAP | AC023590.1,TSC22D3,DNAJA1, etc. | 5.77e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_FAP/regulons_activity_in_dotplot.png) |
BCL6 | EE | Colorectum | FAP | AC023590.1,TSC22D3,DNAJA1, etc. | 5.13e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_FAP/regulons_activity_in_dotplot.png) |
BCL6 | SSC | Colorectum | FAP | AC023590.1,TSC22D3,DNAJA1, etc. | 2.33e-04 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_FAP/regulons_activity_in_dotplot.png) |
BCL6 | GC | Colorectum | ADJ | MYBL1,PAX5,MYO1E, etc. | 2.69e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
BCL6 | GC | Colorectum | CRC | MYBL1,PAX5,MYO1E, etc. | 8.77e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_CRC/regulons_activity_in_dotplot.png) |
BCL6 | GC | Colorectum | FAP | MYBL1,PAX5,MYO1E, etc. | 2.20e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_FAP/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCL6 | SNV | Missense_Mutation | rs772289458 | c.34A>C | p.Thr12Pro | p.T12P | P41182 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-A2-A0CO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
BCL6 | SNV | Missense_Mutation | rs772289458 | c.34A>C | p.Thr12Pro | p.T12P | P41182 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-A7-A4SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
BCL6 | SNV | Missense_Mutation | rs772289458 | c.34N>C | p.Thr12Pro | p.T12P | P41182 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
BCL6 | SNV | Missense_Mutation | | c.710N>T | p.Pro237Leu | p.P237L | P41182 | protein_coding | tolerated(0.58) | benign(0.115) | TCGA-D8-A1JP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
BCL6 | SNV | Missense_Mutation | | c.63C>G | p.Asn21Lys | p.N21K | P41182 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A15G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
BCL6 | SNV | Missense_Mutation | rs772289458 | c.34N>C | p.Thr12Pro | p.T12P | P41182 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-EW-A423-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
BCL6 | SNV | Missense_Mutation | rs759501076 | c.716N>T | p.Pro239Leu | p.P239L | P41182 | protein_coding | tolerated(0.29) | benign(0) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
BCL6 | SNV | Missense_Mutation | rs535108808 | c.1427N>T | p.Thr476Met | p.T476M | P41182 | protein_coding | tolerated(0.06) | benign(0.197) | TCGA-LL-A5YM-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unspecific | letrozole | PD |
BCL6 | SNV | Missense_Mutation | novel | c.978N>T | p.Lys326Asn | p.K326N | P41182 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-UL-AAZ6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | herceptin | SD |
BCL6 | SNV | Missense_Mutation | rs750212558 | c.2075G>A | p.Arg692His | p.R692H | P41182 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |