Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ATF7_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ATF7_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ATF7_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ATF7_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ATF7_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007089712 | Thyroid | ATC | transcription preinitiation complex assembly | 22/6293 | 36/18723 | 6.58e-04 | 3.73e-03 | 22 |
GO:00718242 | Thyroid | ATC | protein-DNA complex subunit organization | 103/6293 | 241/18723 | 1.84e-03 | 9.03e-03 | 103 |
GO:004341412 | Thyroid | ATC | macromolecule methylation | 131/6293 | 316/18723 | 2.01e-03 | 9.60e-03 | 131 |
GO:00458141 | Thyroid | ATC | negative regulation of gene expression, epigenetic | 27/6293 | 50/18723 | 2.35e-03 | 1.10e-02 | 27 |
GO:003225911 | Thyroid | ATC | methylation | 148/6293 | 364/18723 | 2.69e-03 | 1.23e-02 | 148 |
GO:00315071 | Thyroid | ATC | heterochromatin assembly | 22/6293 | 39/18723 | 2.84e-03 | 1.29e-02 | 22 |
GO:007082811 | Thyroid | ATC | heterochromatin organization | 25/6293 | 46/18723 | 3.00e-03 | 1.36e-02 | 25 |
GO:005112311 | Thyroid | ATC | RNA polymerase II preinitiation complex assembly | 15/6293 | 24/18723 | 3.52e-03 | 1.56e-02 | 15 |
GO:200014213 | Thyroid | ATC | regulation of DNA-templated transcription, initiation | 22/6293 | 40/18723 | 4.32e-03 | 1.80e-02 | 22 |
GO:006096815 | Thyroid | ATC | regulation of gene silencing | 38/6293 | 81/18723 | 8.77e-03 | 3.33e-02 | 38 |
GO:006026012 | Thyroid | ATC | regulation of transcription initiation from RNA polymerase II promoter | 18/6293 | 33/18723 | 1.06e-02 | 3.84e-02 | 18 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATF7 | SNV | Missense_Mutation | rs754866750 | c.733A>C | p.Ile245Leu | p.I245L | P17544 | protein_coding | tolerated(0.66) | benign(0) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD |
ATF7 | SNV | Missense_Mutation | rs754866750 | c.733N>C | p.Ile245Leu | p.I245L | P17544 | protein_coding | tolerated(0.66) | benign(0) | TCGA-AN-A0XR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ATF7 | SNV | Missense_Mutation | rs754866750 | c.733A>C | p.Ile245Leu | p.I245L | P17544 | protein_coding | tolerated(0.66) | benign(0) | TCGA-B6-A1KN-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ATF7 | SNV | Missense_Mutation | rs764112606 | c.896N>C | p.His299Pro | p.H299P | P17544 | protein_coding | deleterious(0.03) | benign(0.133) | TCGA-BH-A0B7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ATF7 | SNV | Missense_Mutation | rs754866750 | c.733A>C | p.Ile245Leu | p.I245L | P17544 | protein_coding | tolerated(0.66) | benign(0) | TCGA-BH-A1FH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ATF7 | SNV | Missense_Mutation | rs754866750 | c.733A>C | p.Ile245Leu | p.I245L | P17544 | protein_coding | tolerated(0.66) | benign(0) | TCGA-C8-A273-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ATF7 | SNV | Missense_Mutation | rs754866750 | c.733N>C | p.Ile245Leu | p.I245L | P17544 | protein_coding | tolerated(0.66) | benign(0) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATF7 | SNV | Missense_Mutation | rs754866750 | c.733A>C | p.Ile245Leu | p.I245L | P17544 | protein_coding | tolerated(0.66) | benign(0) | TCGA-D8-A1JT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ATF7 | SNV | Missense_Mutation | rs754866750 | c.733A>C | p.Ile245Leu | p.I245L | P17544 | protein_coding | tolerated(0.66) | benign(0) | TCGA-D8-A1XG-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ATF7 | SNV | Missense_Mutation | | c.61N>C | p.Glu21Gln | p.E21Q | P17544 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-E2-A1L7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |