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Gene: ALDH1A1 |
Gene summary for ALDH1A1 |
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Gene information | Species | Human | Gene symbol | ALDH1A1 | Gene ID | 216 |
Gene name | aldehyde dehydrogenase 1 family member A1 | |
Gene Alias | ALDC | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | P00352 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
216 | ALDH1A1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.20e-03 | 2.01e-01 | 0.0155 |
216 | ALDH1A1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.97e-09 | 3.73e-01 | -0.1808 |
216 | ALDH1A1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.19e-06 | 3.94e-01 | 0.0216 |
216 | ALDH1A1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.57e-08 | 5.37e-01 | -0.0811 |
216 | ALDH1A1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.50e-12 | 5.00e-01 | -0.1088 |
216 | ALDH1A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.47e-08 | 2.56e-01 | -0.1954 |
216 | ALDH1A1 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.10e-03 | 3.23e-01 | -0.1526 |
216 | ALDH1A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.37e-28 | 1.00e+00 | -0.059 |
216 | ALDH1A1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.05e-12 | 4.76e-01 | 0.096 |
216 | ALDH1A1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.03e-11 | 9.04e-01 | 0.0171 |
216 | ALDH1A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.80e-13 | 4.64e-01 | 0.0674 |
216 | ALDH1A1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.05e-47 | 1.55e+00 | 0.294 |
216 | ALDH1A1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.71e-06 | 1.34e+00 | 0.3487 |
216 | ALDH1A1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.97e-17 | 5.88e-01 | 0.3005 |
216 | ALDH1A1 | AEH-subject1 | Human | Endometrium | AEH | 2.43e-38 | -7.93e-01 | -0.3059 |
216 | ALDH1A1 | AEH-subject2 | Human | Endometrium | AEH | 7.86e-28 | -6.94e-01 | -0.2525 |
216 | ALDH1A1 | AEH-subject3 | Human | Endometrium | AEH | 1.56e-26 | -6.69e-01 | -0.2576 |
216 | ALDH1A1 | AEH-subject4 | Human | Endometrium | AEH | 2.26e-09 | -3.80e-01 | -0.2657 |
216 | ALDH1A1 | AEH-subject5 | Human | Endometrium | AEH | 1.69e-47 | -8.24e-01 | -0.2953 |
216 | ALDH1A1 | EEC-subject1 | Human | Endometrium | EEC | 1.00e-38 | -7.75e-01 | -0.2682 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000189431 | Stomach | CAG | tissue homeostasis | 25/552 | 268/18723 | 4.14e-07 | 3.13e-05 | 25 |
GO:006024931 | Stomach | CAG | anatomical structure homeostasis | 27/552 | 314/18723 | 7.25e-07 | 4.98e-05 | 27 |
GO:01100963 | Stomach | CAG | cellular response to aldehyde | 3/552 | 13/18723 | 5.85e-03 | 4.73e-02 | 3 |
GO:00972374 | Stomach | WIM | cellular response to toxic substance | 16/426 | 124/18723 | 2.24e-08 | 2.78e-06 | 16 |
GO:19907484 | Stomach | WIM | cellular detoxification | 15/426 | 116/18723 | 6.00e-08 | 6.26e-06 | 15 |
GO:00987544 | Stomach | WIM | detoxification | 17/426 | 152/18723 | 7.04e-08 | 7.15e-06 | 17 |
GO:00096364 | Stomach | WIM | response to toxic substance | 20/426 | 262/18723 | 2.58e-06 | 1.65e-04 | 20 |
GO:006024941 | Stomach | WIM | anatomical structure homeostasis | 22/426 | 314/18723 | 3.36e-06 | 1.93e-04 | 22 |
GO:000189441 | Stomach | WIM | tissue homeostasis | 20/426 | 268/18723 | 3.64e-06 | 2.03e-04 | 20 |
GO:01202543 | Stomach | WIM | olefinic compound metabolic process | 12/426 | 153/18723 | 2.03e-04 | 4.67e-03 | 12 |
GO:01100964 | Stomach | WIM | cellular response to aldehyde | 3/426 | 13/18723 | 2.82e-03 | 3.11e-02 | 3 |
GO:00987545 | Stomach | SIM | detoxification | 27/708 | 152/18723 | 1.79e-11 | 5.62e-09 | 27 |
GO:00972375 | Stomach | SIM | cellular response to toxic substance | 23/708 | 124/18723 | 2.29e-10 | 5.41e-08 | 23 |
GO:00096365 | Stomach | SIM | response to toxic substance | 34/708 | 262/18723 | 3.51e-10 | 6.55e-08 | 34 |
GO:19907485 | Stomach | SIM | cellular detoxification | 22/708 | 116/18723 | 3.61e-10 | 6.55e-08 | 22 |
GO:00463943 | Stomach | SIM | carboxylic acid biosynthetic process | 30/708 | 314/18723 | 3.33e-06 | 1.57e-04 | 30 |
GO:00160533 | Stomach | SIM | organic acid biosynthetic process | 30/708 | 316/18723 | 3.79e-06 | 1.68e-04 | 30 |
GO:01202544 | Stomach | SIM | olefinic compound metabolic process | 19/708 | 153/18723 | 5.32e-06 | 2.13e-04 | 19 |
GO:006024951 | Stomach | SIM | anatomical structure homeostasis | 28/708 | 314/18723 | 2.52e-05 | 7.73e-04 | 28 |
GO:000189451 | Stomach | SIM | tissue homeostasis | 25/708 | 268/18723 | 3.22e-05 | 9.44e-04 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALDH1A1 | SNV | Missense_Mutation | novel | c.924G>C | p.Arg308Ser | p.R308S | P00352 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ALDH1A1 | SNV | Missense_Mutation | novel | c.311N>T | p.Ala104Val | p.A104V | P00352 | protein_coding | deleterious(0.02) | possibly_damaging(0.712) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALDH1A1 | SNV | Missense_Mutation | novel | c.326T>C | p.Met109Thr | p.M109T | P00352 | protein_coding | deleterious(0.02) | benign(0.006) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALDH1A1 | SNV | Missense_Mutation | c.772N>T | p.Ala258Ser | p.A258S | P00352 | protein_coding | tolerated(0.14) | benign(0.261) | TCGA-BH-A0H9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ALDH1A1 | SNV | Missense_Mutation | c.1502C>T | p.Ser501Leu | p.S501L | P00352 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ALDH1A1 | SNV | Missense_Mutation | c.1492N>G | p.Gln498Glu | p.Q498E | P00352 | protein_coding | tolerated(0.19) | benign(0.001) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ALDH1A1 | SNV | Missense_Mutation | c.250N>A | p.Glu84Lys | p.E84K | P00352 | protein_coding | tolerated(0.18) | possibly_damaging(0.576) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
ALDH1A1 | SNV | Missense_Mutation | novel | c.1497N>C | p.Lys499Asn | p.K499N | P00352 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ALDH1A1 | SNV | Missense_Mutation | c.1436N>T | p.Gly479Val | p.G479V | P00352 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ALDH1A1 | SNV | Missense_Mutation | c.1145T>C | p.Val382Ala | p.V382A | P00352 | protein_coding | deleterious(0) | benign(0.16) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | ROTTLERIN | ROTTLERIN | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | PIRINIXIC ACID | PIRINIXIC ACID | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | SU-4312 | CHEMBL328710 | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | CHLORAMPHENICOL | CHLORAMPHENICOL | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | N- (9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE | N- (9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | SJ000111875 | CHEMBL590949 | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | ZM-449829 | CHEMBL154580 | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | ARACHIDONYL TRIFLUOROMETHYLKETONE | ARACHIDONYL TRIFLUOROMETHYLKETONE | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | BAY-11-7082 | CHEMBL403183 | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | DNDI1417809 | CHEMBL1442783 |
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