GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00067202 | Liver | Cirrhotic | isoprenoid metabolic process | 46/4634 | 116/18723 | 2.71e-04 | 2.41e-03 | 46 |
GO:003025811 | Liver | Cirrhotic | lipid modification | 75/4634 | 212/18723 | 3.33e-04 | 2.87e-03 | 75 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:000155811 | Liver | Cirrhotic | regulation of cell growth | 132/4634 | 414/18723 | 5.53e-04 | 4.36e-03 | 132 |
GO:200105712 | Liver | Cirrhotic | reactive nitrogen species metabolic process | 34/4634 | 82/18723 | 6.36e-04 | 4.85e-03 | 34 |
GO:00107421 | Liver | Cirrhotic | macrophage derived foam cell differentiation | 19/4634 | 38/18723 | 6.75e-04 | 5.06e-03 | 19 |
GO:00900771 | Liver | Cirrhotic | foam cell differentiation | 19/4634 | 38/18723 | 6.75e-04 | 5.06e-03 | 19 |
GO:00343681 | Liver | Cirrhotic | protein-lipid complex remodeling | 16/4634 | 30/18723 | 7.20e-04 | 5.36e-03 | 16 |
GO:00343691 | Liver | Cirrhotic | plasma lipoprotein particle remodeling | 16/4634 | 30/18723 | 7.20e-04 | 5.36e-03 | 16 |
GO:004521612 | Liver | Cirrhotic | cell-cell junction organization | 70/4634 | 200/18723 | 7.23e-04 | 5.36e-03 | 70 |
GO:003812711 | Liver | Cirrhotic | ERBB signaling pathway | 46/4634 | 121/18723 | 8.08e-04 | 5.93e-03 | 46 |
GO:19043851 | Liver | Cirrhotic | cellular response to angiotensin | 14/4634 | 25/18723 | 8.15e-04 | 5.95e-03 | 14 |
GO:0048145 | Liver | Cirrhotic | regulation of fibroblast proliferation | 33/4634 | 80/18723 | 8.46e-04 | 6.12e-03 | 33 |
GO:19907761 | Liver | Cirrhotic | response to angiotensin | 15/4634 | 28/18723 | 9.91e-04 | 6.98e-03 | 15 |
GO:003109812 | Liver | Cirrhotic | stress-activated protein kinase signaling cascade | 83/4634 | 247/18723 | 1.04e-03 | 7.28e-03 | 83 |
GO:004620912 | Liver | Cirrhotic | nitric oxide metabolic process | 33/4634 | 81/18723 | 1.09e-03 | 7.59e-03 | 33 |
GO:0048144 | Liver | Cirrhotic | fibroblast proliferation | 33/4634 | 81/18723 | 1.09e-03 | 7.59e-03 | 33 |
GO:000828611 | Liver | Cirrhotic | insulin receptor signaling pathway | 44/4634 | 116/18723 | 1.09e-03 | 7.59e-03 | 44 |
GO:005140312 | Liver | Cirrhotic | stress-activated MAPK cascade | 80/4634 | 239/18723 | 1.43e-03 | 9.54e-03 | 80 |
GO:000680912 | Liver | Cirrhotic | nitric oxide biosynthetic process | 31/4634 | 76/18723 | 1.49e-03 | 9.87e-03 | 31 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AGT | SNV | Missense_Mutation | | c.257N>T | p.Asp86Val | p.D86V | P01019 | protein_coding | tolerated(0.09) | benign(0.007) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
AGT | SNV | Missense_Mutation | | c.559N>T | p.Val187Leu | p.V187L | P01019 | protein_coding | deleterious(0.01) | benign(0.088) | TCGA-C8-A134-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
AGT | SNV | Missense_Mutation | | c.1052N>G | p.Ser351Cys | p.S351C | P01019 | protein_coding | deleterious(0) | possibly_damaging(0.729) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
AGT | SNV | Missense_Mutation | novel | c.740C>A | p.Ala247Asp | p.A247D | P01019 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A27F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
AGT | SNV | Missense_Mutation | novel | c.815T>A | p.Val272Glu | p.V272E | P01019 | protein_coding | deleterious(0) | benign(0) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AGT | insertion | Frame_Shift_Ins | novel | c.718_719insT | p.Asp240ValfsTer10 | p.D240Vfs*10 | P01019 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
AGT | insertion | Frame_Shift_Ins | novel | c.716_717insAGGATTTGGAGCTGCAGGGAAACGTGCTCCACAA | p.Asp240GlyfsTer21 | p.D240Gfs*21 | P01019 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
AGT | insertion | In_Frame_Ins | novel | c.949_950insAGGAGAGGAAGAATGCTTTTTCTACAC | p.Gly317delinsGluGluArgLysAsnAlaPheSerThrArg | p.G317delinsEERKNAFSTR | P01019 | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
AGT | insertion | Frame_Shift_Ins | novel | c.366_367insTTGAAGGTTACGCAAG | p.Glu123LeufsTer39 | p.E123Lfs*39 | P01019 | protein_coding | | | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AGT | SNV | Missense_Mutation | rs760531325 | c.142N>A | p.Glu48Lys | p.E48K | P01019 | protein_coding | tolerated(1) | benign(0) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | QUINAPRIL | QUINAPRIL | 12693379,11849656 |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | chlorthalidone | CHLORTHALIDONE | |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | CYCLOSPORIN A | | 10642325 |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | ADENOVIRUS VECTOR | | 16014023 |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | Antiinflammatory agents, non-steroids | | 20538124 |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | CORTISOL | HYDROCORTISONE | 15576665 |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | Ace Inhibitors, Plain | | 14643574 |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | atenolol | ATENOLOL | 11593098,14700505 |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | irbesartan | IRBESARTAN | 11593098,15614026,14700505 |
183 | AGT | ENZYME, DRUGGABLE GENOME, PROTEASE INHIBITOR, G PROTEIN COUPLED RECEPTOR, HORMONE ACTIVITY, GROWTH FACTOR | | ANTI-ANGIOGENIC AGENTS | | 15578913 |