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Gene: ZNF710 |
Gene summary for ZNF710 |
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Gene information | Species | Human | Gene symbol | ZNF710 | Gene ID | 374655 |
Gene name | zinc finger protein 710 | |
Gene Alias | ZNF710 | |
Cytomap | 15q26.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N1W2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374655 | ZNF710 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.26e-04 | -3.98e-01 | 0.0155 |
374655 | ZNF710 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.41e-08 | -4.51e-01 | 0.294 |
374655 | ZNF710 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.91e-08 | -4.73e-01 | 0.3859 |
374655 | ZNF710 | F007 | Human | Colorectum | FAP | 4.14e-04 | -3.45e-01 | 0.1176 |
374655 | ZNF710 | A001-C-207 | Human | Colorectum | FAP | 2.65e-02 | -2.33e-01 | 0.1278 |
374655 | ZNF710 | A015-C-203 | Human | Colorectum | FAP | 3.21e-21 | -3.82e-01 | -0.1294 |
374655 | ZNF710 | A015-C-204 | Human | Colorectum | FAP | 6.93e-04 | -3.23e-01 | -0.0228 |
374655 | ZNF710 | A014-C-040 | Human | Colorectum | FAP | 3.82e-05 | -6.12e-01 | -0.1184 |
374655 | ZNF710 | A002-C-201 | Human | Colorectum | FAP | 3.18e-11 | -4.14e-01 | 0.0324 |
374655 | ZNF710 | A001-C-119 | Human | Colorectum | FAP | 9.01e-05 | -2.85e-01 | -0.1557 |
374655 | ZNF710 | A001-C-108 | Human | Colorectum | FAP | 1.26e-12 | -3.37e-01 | -0.0272 |
374655 | ZNF710 | A002-C-205 | Human | Colorectum | FAP | 3.46e-17 | -3.85e-01 | -0.1236 |
374655 | ZNF710 | A015-C-005 | Human | Colorectum | FAP | 3.08e-04 | -2.98e-01 | -0.0336 |
374655 | ZNF710 | A015-C-006 | Human | Colorectum | FAP | 4.93e-15 | -5.42e-01 | -0.0994 |
374655 | ZNF710 | A015-C-106 | Human | Colorectum | FAP | 1.75e-11 | -3.83e-01 | -0.0511 |
374655 | ZNF710 | A002-C-114 | Human | Colorectum | FAP | 1.62e-17 | -5.41e-01 | -0.1561 |
374655 | ZNF710 | A015-C-104 | Human | Colorectum | FAP | 1.46e-21 | -4.28e-01 | -0.1899 |
374655 | ZNF710 | A001-C-014 | Human | Colorectum | FAP | 3.86e-12 | -3.67e-01 | 0.0135 |
374655 | ZNF710 | A002-C-016 | Human | Colorectum | FAP | 7.72e-19 | -4.28e-01 | 0.0521 |
374655 | ZNF710 | A015-C-002 | Human | Colorectum | FAP | 1.48e-11 | -4.73e-01 | -0.0763 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF710 | SNV | Missense_Mutation | rs754631276 | c.121G>A | p.Glu41Lys | p.E41K | Q8N1W2 | protein_coding | tolerated_low_confidence(0.1) | benign(0.019) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
ZNF710 | SNV | Missense_Mutation | novel | c.1596G>T | p.Gln532His | p.Q532H | Q8N1W2 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AC-A3YI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
ZNF710 | SNV | Missense_Mutation | novel | c.1048N>T | p.Pro350Ser | p.P350S | Q8N1W2 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF710 | SNV | Missense_Mutation | novel | c.1202A>G | p.His401Arg | p.H401R | Q8N1W2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF710 | SNV | Missense_Mutation | c.709C>T | p.Pro237Ser | p.P237S | Q8N1W2 | protein_coding | tolerated_low_confidence(0.39) | benign(0.026) | TCGA-C8-A132-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF710 | SNV | Missense_Mutation | c.1725C>G | p.Phe575Leu | p.F575L | Q8N1W2 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-D8-A1XV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF710 | SNV | Missense_Mutation | rs764750149 | c.914C>T | p.Thr305Met | p.T305M | Q8N1W2 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-E9-A1RC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD |
ZNF710 | insertion | In_Frame_Ins | novel | c.1550_1551insTAT | p.Arg517_Pro518insMet | p.R517_P518insM | Q8N1W2 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
ZNF710 | insertion | Frame_Shift_Ins | novel | c.1551_1552insTACACATCCA | p.Pro518TyrfsTer71 | p.P518Yfs*71 | Q8N1W2 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
ZNF710 | SNV | Missense_Mutation | novel | c.956N>A | p.Gly319Asp | p.G319D | Q8N1W2 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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