![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF576 |
Gene summary for ZNF576 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF576 | Gene ID | 79177 |
Gene name | zinc finger protein 576 | |
Gene Alias | ZNF576 | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R0T0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79177 | ZNF576 | LZE4T | Human | Esophagus | ESCC | 1.42e-04 | 1.47e-01 | 0.0811 |
79177 | ZNF576 | LZE5T | Human | Esophagus | ESCC | 5.15e-06 | 3.74e-01 | 0.0514 |
79177 | ZNF576 | LZE7T | Human | Esophagus | ESCC | 8.36e-09 | 2.69e-01 | 0.0667 |
79177 | ZNF576 | LZE8T | Human | Esophagus | ESCC | 1.35e-08 | 1.96e-01 | 0.067 |
79177 | ZNF576 | LZE20T | Human | Esophagus | ESCC | 7.38e-04 | 1.27e-01 | 0.0662 |
79177 | ZNF576 | LZE24T | Human | Esophagus | ESCC | 9.01e-20 | 3.52e-01 | 0.0596 |
79177 | ZNF576 | P1T-E | Human | Esophagus | ESCC | 1.30e-12 | 3.83e-01 | 0.0875 |
79177 | ZNF576 | P2T-E | Human | Esophagus | ESCC | 3.81e-20 | 3.05e-01 | 0.1177 |
79177 | ZNF576 | P4T-E | Human | Esophagus | ESCC | 2.66e-19 | 3.48e-01 | 0.1323 |
79177 | ZNF576 | P5T-E | Human | Esophagus | ESCC | 3.86e-15 | 2.78e-01 | 0.1327 |
79177 | ZNF576 | P8T-E | Human | Esophagus | ESCC | 5.48e-26 | 5.08e-01 | 0.0889 |
79177 | ZNF576 | P9T-E | Human | Esophagus | ESCC | 1.18e-15 | 2.19e-01 | 0.1131 |
79177 | ZNF576 | P10T-E | Human | Esophagus | ESCC | 1.54e-25 | 5.25e-01 | 0.116 |
79177 | ZNF576 | P11T-E | Human | Esophagus | ESCC | 2.47e-10 | 3.61e-01 | 0.1426 |
79177 | ZNF576 | P12T-E | Human | Esophagus | ESCC | 5.96e-14 | 2.91e-01 | 0.1122 |
79177 | ZNF576 | P15T-E | Human | Esophagus | ESCC | 3.57e-19 | 3.51e-01 | 0.1149 |
79177 | ZNF576 | P16T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.86e-01 | 0.1153 |
79177 | ZNF576 | P17T-E | Human | Esophagus | ESCC | 1.28e-06 | 2.69e-01 | 0.1278 |
79177 | ZNF576 | P20T-E | Human | Esophagus | ESCC | 4.81e-21 | 3.54e-01 | 0.1124 |
79177 | ZNF576 | P21T-E | Human | Esophagus | ESCC | 1.07e-08 | 1.82e-01 | 0.1617 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF576 | SNV | Missense_Mutation | c.180C>G | p.Asp60Glu | p.D60E | Q9H609 | protein_coding | tolerated(0.64) | benign(0.234) | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
ZNF576 | SNV | Missense_Mutation | novel | c.44N>T | p.Ser15Leu | p.S15L | Q9H609 | protein_coding | deleterious_low_confidence(0.05) | benign(0.001) | TCGA-C5-A907-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF576 | SNV | Missense_Mutation | c.202N>A | p.Gly68Arg | p.G68R | Q9H609 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF576 | SNV | Missense_Mutation | c.431N>T | p.Ala144Val | p.A144V | Q9H609 | protein_coding | tolerated(0.57) | benign(0.396) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF576 | SNV | Missense_Mutation | c.275N>A | p.Ser92Asn | p.S92N | Q9H609 | protein_coding | deleterious(0.03) | benign(0.247) | TCGA-CK-4947-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Other, specify in notes | folinic | SD | |
ZNF576 | SNV | Missense_Mutation | c.271N>T | p.Arg91Cys | p.R91C | Q9H609 | protein_coding | deleterious(0.03) | benign(0.093) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF576 | SNV | Missense_Mutation | rs772352799 | c.229N>A | p.Ala77Thr | p.A77T | Q9H609 | protein_coding | tolerated(0.25) | possibly_damaging(0.598) | TCGA-A5-A0VO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF576 | SNV | Missense_Mutation | c.91N>A | p.Leu31Met | p.L31M | Q9H609 | protein_coding | tolerated(0.08) | possibly_damaging(0.467) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF576 | SNV | Missense_Mutation | c.230N>T | p.Ala77Val | p.A77V | Q9H609 | protein_coding | tolerated(0.07) | possibly_damaging(0.659) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF576 | SNV | Missense_Mutation | rs568418404 | c.152G>A | p.Arg51His | p.R51H | Q9H609 | protein_coding | tolerated(0.07) | probably_damaging(0.958) | TCGA-AP-A1DR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |