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Gene: ZNF566 |
Gene summary for ZNF566 |
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Gene information | Species | Human | Gene symbol | ZNF566 | Gene ID | 84924 |
Gene name | zinc finger protein 566 | |
Gene Alias | ZNF566 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q969W8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84924 | ZNF566 | HCC1_Meng | Human | Liver | HCC | 3.41e-21 | -1.56e-02 | 0.0246 |
84924 | ZNF566 | HCC1 | Human | Liver | HCC | 1.11e-07 | 2.35e+00 | 0.5336 |
84924 | ZNF566 | HCC2 | Human | Liver | HCC | 7.80e-15 | 2.06e+00 | 0.5341 |
84924 | ZNF566 | HCC5 | Human | Liver | HCC | 2.25e-09 | 1.32e+00 | 0.4932 |
84924 | ZNF566 | male-WTA | Human | Thyroid | PTC | 4.80e-06 | 8.91e-02 | 0.1037 |
84924 | ZNF566 | PTC01 | Human | Thyroid | PTC | 1.70e-07 | 9.24e-02 | 0.1899 |
84924 | ZNF566 | PTC04 | Human | Thyroid | PTC | 1.28e-05 | 9.80e-02 | 0.1927 |
84924 | ZNF566 | PTC06 | Human | Thyroid | PTC | 3.13e-12 | 2.78e-01 | 0.2057 |
84924 | ZNF566 | PTC07 | Human | Thyroid | PTC | 3.70e-13 | 2.09e-01 | 0.2044 |
84924 | ZNF566 | ATC12 | Human | Thyroid | ATC | 1.79e-02 | 6.06e-02 | 0.34 |
84924 | ZNF566 | ATC13 | Human | Thyroid | ATC | 1.62e-83 | 1.45e+00 | 0.34 |
84924 | ZNF566 | ATC2 | Human | Thyroid | ATC | 2.98e-03 | 2.54e-01 | 0.34 |
84924 | ZNF566 | ATC4 | Human | Thyroid | ATC | 2.66e-02 | 8.55e-02 | 0.34 |
84924 | ZNF566 | ATC5 | Human | Thyroid | ATC | 5.71e-98 | 1.53e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF566 | SNV | Missense_Mutation | novel | c.49N>G | p.Gln17Glu | p.Q17E | Q969W8 | protein_coding | deleterious(0.03) | possibly_damaging(0.755) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ZNF566 | SNV | Missense_Mutation | novel | c.997N>G | p.Ile333Val | p.I333V | Q969W8 | protein_coding | tolerated(0.08) | possibly_damaging(0.808) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF566 | SNV | Missense_Mutation | c.871N>G | p.Lys291Glu | p.K291E | Q969W8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C5-A1BN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF566 | SNV | Missense_Mutation | c.250N>C | p.Cys84Arg | p.C84R | Q969W8 | protein_coding | tolerated(0.18) | possibly_damaging(0.472) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF566 | SNV | Missense_Mutation | c.158C>A | p.Pro53Gln | p.P53Q | Q969W8 | protein_coding | deleterious(0) | benign(0.135) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF566 | SNV | Missense_Mutation | novel | c.832N>T | p.His278Tyr | p.H278Y | Q969W8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
ZNF566 | SNV | Missense_Mutation | novel | c.206N>G | p.Asp69Gly | p.D69G | Q969W8 | protein_coding | tolerated(0.39) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF566 | SNV | Missense_Mutation | c.261N>T | p.Lys87Asn | p.K87N | Q969W8 | protein_coding | tolerated(0.12) | possibly_damaging(0.575) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF566 | SNV | Missense_Mutation | c.88N>G | p.Leu30Val | p.L30V | Q969W8 | protein_coding | deleterious(0) | benign(0.407) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF566 | SNV | Missense_Mutation | c.776A>C | p.Lys259Thr | p.K259T | Q969W8 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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