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Gene: ZNF496 |
Gene summary for ZNF496 |
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Gene information | Species | Human | Gene symbol | ZNF496 | Gene ID | 84838 |
Gene name | zinc finger protein 496 | |
Gene Alias | NIZP1 | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R5Q5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84838 | ZNF496 | HCC1_Meng | Human | Liver | HCC | 2.06e-25 | 5.30e-02 | 0.0246 |
84838 | ZNF496 | HCC1 | Human | Liver | HCC | 8.25e-03 | 2.85e+00 | 0.5336 |
84838 | ZNF496 | HCC2 | Human | Liver | HCC | 4.91e-02 | 1.00e+00 | 0.5341 |
84838 | ZNF496 | S014 | Human | Liver | HCC | 1.56e-12 | 3.96e-01 | 0.2254 |
84838 | ZNF496 | S015 | Human | Liver | HCC | 6.57e-07 | 3.21e-01 | 0.2375 |
84838 | ZNF496 | S016 | Human | Liver | HCC | 5.06e-11 | 3.47e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF496 | SNV | Missense_Mutation | novel | c.8N>T | p.Thr3Ile | p.T3I | Q96IT1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.99) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ZNF496 | SNV | Missense_Mutation | novel | c.694N>A | p.Glu232Lys | p.E232K | Q96IT1 | protein_coding | deleterious(0.01) | benign(0.396) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
ZNF496 | SNV | Missense_Mutation | c.215N>T | p.Arg72Leu | p.R72L | Q96IT1 | protein_coding | deleterious(0) | possibly_damaging(0.643) | TCGA-AR-A24Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZNF496 | SNV | Missense_Mutation | rs754694981 | c.835N>T | p.Arg279Cys | p.R279C | Q96IT1 | protein_coding | tolerated(0.14) | benign(0) | TCGA-BH-A0EI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF496 | SNV | Missense_Mutation | c.1192G>A | p.Glu398Lys | p.E398K | Q96IT1 | protein_coding | tolerated(0.27) | benign(0.272) | TCGA-BH-A209-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF496 | SNV | Missense_Mutation | c.220N>A | p.Glu74Lys | p.E74K | Q96IT1 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF496 | SNV | Missense_Mutation | c.307N>T | p.Arg103Trp | p.R103W | Q96IT1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF496 | SNV | Missense_Mutation | c.406N>T | p.Asp136Tyr | p.D136Y | Q96IT1 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF496 | SNV | Missense_Mutation | c.254N>G | p.Leu85Arg | p.L85R | Q96IT1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF496 | SNV | Missense_Mutation | c.1514N>T | p.Ala505Val | p.A505V | Q96IT1 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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