Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ZNF394_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ZNF394_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ZNF394_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ZNF394_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF394 | CT | Colorectum | ADJ | KLHL13,FAM155A,IDH3B, etc. | 4.74e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF394 | SSC | Colorectum | ADJ | KLHL13,FAM155A,IDH3B, etc. | 8.61e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF394 | PERI | Oral cavity | LP | NAA35,PHACTR1,ADAMTS3, etc. | 1.26e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_LP/regulons_activity_in_dotplot.png) |
ZNF394 | PERI | Oral cavity | OSCC | NAA35,PHACTR1,ADAMTS3, etc. | 1.18e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_OSCC/regulons_activity_in_dotplot.png) |
ZNF394 | LYMEND | Skin | cSCC | NAP1L5,NAT14,PLPBP, etc. | 2.03e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Skin/Str/TF_cSCC/regulons_activity_in_dotplot.png) |
ZNF394 | PTC | Thyroid | Healthy | LIPA,MTERF4,RCHY1, etc. | 1.73e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF394 | SNV | Missense_Mutation | | c.38N>G | p.Asp13Gly | p.D13G | Q53GI3 | protein_coding | tolerated_low_confidence(0.18) | benign(0.001) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
ZNF394 | SNV | Missense_Mutation | novel | c.728N>G | p.Val243Gly | p.V243G | Q53GI3 | protein_coding | tolerated(0.11) | benign(0) | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR |
ZNF394 | SNV | Missense_Mutation | novel | c.428N>G | p.Gln143Arg | p.Q143R | Q53GI3 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-AC-A3EH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF394 | SNV | Missense_Mutation | novel | c.821G>T | p.Gly274Val | p.G274V | Q53GI3 | protein_coding | tolerated(0.55) | benign(0.005) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF394 | SNV | Missense_Mutation | novel | c.519C>A | p.Asp173Glu | p.D173E | Q53GI3 | protein_coding | tolerated(0.52) | benign(0.127) | TCGA-AC-A6IX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF394 | SNV | Missense_Mutation | | c.206N>C | p.Gln69Pro | p.Q69P | Q53GI3 | protein_coding | deleterious(0.01) | possibly_damaging(0.825) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF394 | SNV | Missense_Mutation | rs769653041 | c.1514G>A | p.Arg505His | p.R505H | Q53GI3 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZNF394 | SNV | Missense_Mutation | | c.190N>G | p.Arg64Gly | p.R64G | Q53GI3 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF394 | insertion | Nonsense_Mutation | novel | c.739_740insTTCAAACAACGCTCTGACCTCTTTAGACA | p.Ser247PhefsTer6 | p.S247Ffs*6 | Q53GI3 | protein_coding | | | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF394 | insertion | Nonsense_Mutation | novel | c.1108_1109insCAAAGAATTCATCAAAATAAAGT | p.Arg370ProfsTer7 | p.R370Pfs*7 | Q53GI3 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |