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Gene: ZNF254 |
Gene summary for ZNF254 |
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Gene information | Species | Human | Gene symbol | ZNF254 | Gene ID | 9534 |
Gene name | zinc finger protein 254 | |
Gene Alias | BMZF-5 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A087WZJ7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9534 | ZNF254 | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.44e-02 | 5.46e-01 | 0.3371 |
9534 | ZNF254 | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.28e-04 | 6.03e-01 | 0.343 |
9534 | ZNF254 | RNA-P17T-P17T-6 | Human | Lung | IAC | 3.22e-04 | 6.62e-01 | 0.3385 |
9534 | ZNF254 | RNA-P17T-P17T-8 | Human | Lung | IAC | 3.74e-04 | 4.53e-01 | 0.3329 |
9534 | ZNF254 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 8.44e-04 | 3.42e-01 | -0.2116 |
9534 | ZNF254 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.54e-04 | 4.50e-01 | -0.2119 |
9534 | ZNF254 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.26e-07 | 3.90e-01 | -0.0166 |
9534 | ZNF254 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 7.86e-05 | 3.20e-01 | -0.0132 |
9534 | ZNF254 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 5.91e-11 | 3.92e-01 | -0.013 |
9534 | ZNF254 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 4.47e-09 | 4.16e-01 | -0.0121 |
9534 | ZNF254 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 4.47e-02 | 3.46e-01 | -0.0876 |
9534 | ZNF254 | male-WTA | Human | Thyroid | PTC | 2.30e-14 | 1.08e-01 | 0.1037 |
9534 | ZNF254 | PTC01 | Human | Thyroid | PTC | 1.80e-06 | 4.50e-02 | 0.1899 |
9534 | ZNF254 | PTC03 | Human | Thyroid | PTC | 4.20e-03 | 1.48e-01 | 0.1784 |
9534 | ZNF254 | PTC04 | Human | Thyroid | PTC | 4.04e-15 | 2.38e-01 | 0.1927 |
9534 | ZNF254 | PTC05 | Human | Thyroid | PTC | 2.17e-09 | 6.70e-01 | 0.2065 |
9534 | ZNF254 | PTC06 | Human | Thyroid | PTC | 1.35e-28 | 8.15e-01 | 0.2057 |
9534 | ZNF254 | PTC07 | Human | Thyroid | PTC | 1.23e-27 | 4.35e-01 | 0.2044 |
9534 | ZNF254 | ATC12 | Human | Thyroid | ATC | 2.38e-02 | -4.01e-02 | 0.34 |
9534 | ZNF254 | ATC13 | Human | Thyroid | ATC | 3.29e-23 | 3.54e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF254 | SNV | Missense_Mutation | c.1968N>G | p.Ile656Met | p.I656M | O75437 | protein_coding | tolerated(0.12) | benign(0.01) | TCGA-BH-A0BG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF254 | SNV | Missense_Mutation | rs753170366 | c.1508C>T | p.Ser503Leu | p.S503L | O75437 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
ZNF254 | SNV | Missense_Mutation | c.17G>A | p.Arg6Lys | p.R6K | O75437 | protein_coding | tolerated(0.87) | benign(0.031) | TCGA-D8-A27L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin+cuclophosphamide | SD | |
ZNF254 | SNV | Missense_Mutation | c.1592N>T | p.Ser531Leu | p.S531L | O75437 | protein_coding | deleterious(0.02) | possibly_damaging(0.823) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
ZNF254 | SNV | Missense_Mutation | rs752612869 | c.546N>G | p.Phe182Leu | p.F182L | O75437 | protein_coding | tolerated(0.14) | benign(0.075) | TCGA-GM-A3NW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
ZNF254 | SNV | Missense_Mutation | rs367945545 | c.1361N>T | p.Arg454Ile | p.R454I | O75437 | protein_coding | tolerated(0.41) | benign(0.082) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF254 | SNV | Missense_Mutation | rs540732767 | c.1487N>A | p.Gly496Asp | p.G496D | O75437 | protein_coding | tolerated(0.06) | probably_damaging(0.965) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF254 | SNV | Missense_Mutation | novel | c.577A>G | p.Met193Val | p.M193V | O75437 | protein_coding | tolerated(0.13) | benign(0.017) | TCGA-JW-AAVH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF254 | SNV | Missense_Mutation | c.668C>T | p.Ser223Leu | p.S223L | O75437 | protein_coding | tolerated(0.07) | possibly_damaging(0.613) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
ZNF254 | SNV | Missense_Mutation | c.812N>A | p.Cys271Tyr | p.C271Y | O75437 | protein_coding | deleterious(0.01) | probably_damaging(0.91) | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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