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Gene: YPEL2 |
Gene summary for YPEL2 |
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Gene information | Species | Human | Gene symbol | YPEL2 | Gene ID | 388403 |
Gene name | yippee like 2 | |
Gene Alias | FKSG4 | |
Cytomap | 17q22 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96QA6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388403 | YPEL2 | LZE5T | Human | Esophagus | ESCC | 5.38e-04 | 3.96e-01 | 0.0514 |
388403 | YPEL2 | LZE24T | Human | Esophagus | ESCC | 1.03e-17 | 6.39e-01 | 0.0596 |
388403 | YPEL2 | P1T-E | Human | Esophagus | ESCC | 4.82e-03 | 2.44e-01 | 0.0875 |
388403 | YPEL2 | P2T-E | Human | Esophagus | ESCC | 9.88e-14 | 2.06e-01 | 0.1177 |
388403 | YPEL2 | P4T-E | Human | Esophagus | ESCC | 1.33e-06 | 9.37e-02 | 0.1323 |
388403 | YPEL2 | P8T-E | Human | Esophagus | ESCC | 4.54e-32 | 1.08e+00 | 0.0889 |
388403 | YPEL2 | P9T-E | Human | Esophagus | ESCC | 1.71e-05 | 1.19e-01 | 0.1131 |
388403 | YPEL2 | P10T-E | Human | Esophagus | ESCC | 1.23e-07 | 7.48e-02 | 0.116 |
388403 | YPEL2 | P11T-E | Human | Esophagus | ESCC | 3.59e-05 | 2.11e-01 | 0.1426 |
388403 | YPEL2 | P12T-E | Human | Esophagus | ESCC | 7.75e-04 | 2.75e-02 | 0.1122 |
388403 | YPEL2 | P15T-E | Human | Esophagus | ESCC | 1.46e-11 | 1.83e-01 | 0.1149 |
388403 | YPEL2 | P16T-E | Human | Esophagus | ESCC | 1.41e-18 | 1.78e-01 | 0.1153 |
388403 | YPEL2 | P22T-E | Human | Esophagus | ESCC | 1.14e-09 | 1.12e-01 | 0.1236 |
388403 | YPEL2 | P23T-E | Human | Esophagus | ESCC | 1.32e-20 | 6.79e-01 | 0.108 |
388403 | YPEL2 | P24T-E | Human | Esophagus | ESCC | 1.54e-02 | 9.63e-02 | 0.1287 |
388403 | YPEL2 | P26T-E | Human | Esophagus | ESCC | 3.69e-07 | 1.04e-01 | 0.1276 |
388403 | YPEL2 | P30T-E | Human | Esophagus | ESCC | 1.34e-08 | 3.10e-01 | 0.137 |
388403 | YPEL2 | P31T-E | Human | Esophagus | ESCC | 3.47e-08 | 1.04e-01 | 0.1251 |
388403 | YPEL2 | P36T-E | Human | Esophagus | ESCC | 4.21e-08 | 3.62e-01 | 0.1187 |
388403 | YPEL2 | P37T-E | Human | Esophagus | ESCC | 2.59e-04 | 1.20e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YPEL2 | SNV | Missense_Mutation | rs186477591 | c.223N>A | p.Ala75Thr | p.A75T | Q96QA6 | protein_coding | tolerated(0.06) | benign(0.419) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
YPEL2 | SNV | Missense_Mutation | c.287G>A | p.Ser96Asn | p.S96N | Q96QA6 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
YPEL2 | SNV | Missense_Mutation | novel | c.239N>G | p.Glu80Gly | p.E80G | Q96QA6 | protein_coding | tolerated(0.32) | benign(0.186) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
YPEL2 | SNV | Missense_Mutation | c.97C>G | p.His33Asp | p.H33D | Q96QA6 | protein_coding | deleterious(0.02) | possibly_damaging(0.527) | TCGA-AP-A0LF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
YPEL2 | SNV | Missense_Mutation | novel | c.349N>T | p.Gly117Cys | p.G117C | Q96QA6 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AP-A1DM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
YPEL2 | SNV | Missense_Mutation | novel | c.355G>T | p.Asp119Tyr | p.D119Y | Q96QA6 | protein_coding | deleterious(0) | possibly_damaging(0.855) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
YPEL2 | SNV | Missense_Mutation | novel | c.122T>C | p.Phe41Ser | p.F41S | Q96QA6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
YPEL2 | SNV | Missense_Mutation | c.287N>A | p.Ser96Asn | p.S96N | Q96QA6 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
YPEL2 | SNV | Missense_Mutation | c.153N>G | p.Phe51Leu | p.F51L | Q96QA6 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
YPEL2 | SNV | Missense_Mutation | novel | c.256N>G | p.Leu86Val | p.L86V | Q96QA6 | protein_coding | tolerated(0.32) | probably_damaging(0.925) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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