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Gene: WNT5A |
Gene summary for WNT5A |
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Gene information | Species | Human | Gene symbol | WNT5A | Gene ID | 7474 |
Gene name | Wnt family member 5A | |
Gene Alias | hWNT5A | |
Cytomap | 3p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R316 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7474 | WNT5A | LZE4T | Human | Esophagus | ESCC | 1.47e-05 | 2.62e-01 | 0.0811 |
7474 | WNT5A | P4T-E | Human | Esophagus | ESCC | 1.29e-08 | 3.40e-01 | 0.1323 |
7474 | WNT5A | P8T-E | Human | Esophagus | ESCC | 9.35e-12 | 2.41e-01 | 0.0889 |
7474 | WNT5A | P9T-E | Human | Esophagus | ESCC | 7.73e-07 | 2.00e-01 | 0.1131 |
7474 | WNT5A | P10T-E | Human | Esophagus | ESCC | 7.80e-11 | 2.40e-01 | 0.116 |
7474 | WNT5A | P12T-E | Human | Esophagus | ESCC | 2.33e-33 | 6.94e-01 | 0.1122 |
7474 | WNT5A | P15T-E | Human | Esophagus | ESCC | 6.29e-13 | 3.25e-01 | 0.1149 |
7474 | WNT5A | P22T-E | Human | Esophagus | ESCC | 6.11e-04 | 1.56e-01 | 0.1236 |
7474 | WNT5A | P23T-E | Human | Esophagus | ESCC | 5.15e-05 | 3.79e-01 | 0.108 |
7474 | WNT5A | P24T-E | Human | Esophagus | ESCC | 7.66e-05 | 2.02e-01 | 0.1287 |
7474 | WNT5A | P26T-E | Human | Esophagus | ESCC | 1.93e-16 | 3.97e-01 | 0.1276 |
7474 | WNT5A | P27T-E | Human | Esophagus | ESCC | 6.39e-18 | 3.45e-01 | 0.1055 |
7474 | WNT5A | P28T-E | Human | Esophagus | ESCC | 4.38e-05 | 7.38e-02 | 0.1149 |
7474 | WNT5A | P30T-E | Human | Esophagus | ESCC | 3.26e-21 | 9.54e-01 | 0.137 |
7474 | WNT5A | P32T-E | Human | Esophagus | ESCC | 9.60e-09 | 2.51e-01 | 0.1666 |
7474 | WNT5A | P36T-E | Human | Esophagus | ESCC | 4.78e-07 | 3.85e-01 | 0.1187 |
7474 | WNT5A | P39T-E | Human | Esophagus | ESCC | 2.79e-12 | 2.82e-01 | 0.0894 |
7474 | WNT5A | P42T-E | Human | Esophagus | ESCC | 4.51e-07 | 4.71e-01 | 0.1175 |
7474 | WNT5A | P47T-E | Human | Esophagus | ESCC | 1.69e-02 | 2.39e-01 | 0.1067 |
7474 | WNT5A | P48T-E | Human | Esophagus | ESCC | 6.01e-11 | 2.86e-01 | 0.0959 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:0043122110 | Esophagus | ESCC | regulation of I-kappaB kinase/NF-kappaB signaling | 167/8552 | 249/18723 | 6.11e-12 | 2.32e-10 | 167 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:007190016 | Esophagus | ESCC | regulation of protein serine/threonine kinase activity | 227/8552 | 359/18723 | 1.12e-11 | 4.10e-10 | 227 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:0051099111 | Esophagus | ESCC | positive regulation of binding | 122/8552 | 173/18723 | 2.79e-11 | 9.45e-10 | 122 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:004339320 | Esophagus | ESCC | regulation of protein binding | 135/8552 | 196/18723 | 3.69e-11 | 1.22e-09 | 135 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:003434013 | Esophagus | ESCC | response to type I interferon | 48/8552 | 58/18723 | 6.18e-09 | 1.26e-07 | 48 |
GO:000184115 | Esophagus | ESCC | neural tube formation | 75/8552 | 102/18723 | 9.68e-09 | 1.95e-07 | 75 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa0522518 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa041505 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520537 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa0522519 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa0415013 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
WNT5A | FZD1 | WNT5A_FZD1 | ncWNT | Cervix | ADJ |
WNT5A | FZD4 | WNT5A_FZD4 | ncWNT | Cervix | ADJ |
WNT5A | FZD6 | WNT5A_FZD6 | ncWNT | Cervix | ADJ |
WNT5A | FZD7 | WNT5A_FZD7 | ncWNT | Cervix | ADJ |
WNT5A | MCAM | WNT5A_MCAM | ncWNT | Cervix | ADJ |
WNT5A | FZD4 | WNT5A_FZD4 | ncWNT | Cervix | CC |
WNT5A | FZD6 | WNT5A_FZD6 | ncWNT | Cervix | CC |
WNT5A | MCAM | WNT5A_MCAM | ncWNT | Cervix | CC |
WNT5A | MCAM | WNT5A_MCAM | ncWNT | Cervix | Precancer |
WNT5A | FZD4 | WNT5A_FZD4 | ncWNT | Endometrium | ADJ |
WNT5A | FZD6 | WNT5A_FZD6 | ncWNT | Endometrium | ADJ |
WNT5A | MCAM | WNT5A_MCAM | ncWNT | Endometrium | ADJ |
WNT5A | FZD4 | WNT5A_FZD4 | ncWNT | Endometrium | AEH |
WNT5A | FZD7 | WNT5A_FZD7 | ncWNT | Endometrium | AEH |
WNT5A | MCAM | WNT5A_MCAM | ncWNT | Endometrium | AEH |
WNT5A | MCAM | WNT5A_MCAM | ncWNT | Endometrium | Healthy |
WNT5A | FZD1 | WNT5A_FZD1 | ncWNT | Esophagus | ESCC |
WNT5A | FZD10 | WNT5A_FZD10 | ncWNT | Esophagus | ESCC |
WNT5A | FZD3 | WNT5A_FZD3 | ncWNT | Esophagus | ESCC |
WNT5A | FZD4 | WNT5A_FZD4 | ncWNT | Esophagus | ESCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WNT5A | SNV | Missense_Mutation | rs369954366 | c.830G>A | p.Arg277Gln | p.R277Q | P41221 | protein_coding | tolerated(0.05) | possibly_damaging(0.65) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WNT5A | SNV | Missense_Mutation | novel | c.947N>A | p.Gly316Asp | p.G316D | P41221 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
WNT5A | SNV | Missense_Mutation | rs755298573 | c.1055N>T | p.Thr352Met | p.T352M | P41221 | protein_coding | tolerated(0.09) | possibly_damaging(0.502) | TCGA-UC-A7PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
WNT5A | SNV | Missense_Mutation | c.758G>T | p.Trp253Leu | p.W253L | P41221 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3489-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
WNT5A | SNV | Missense_Mutation | c.442N>T | p.Asn148Tyr | p.N148Y | P41221 | protein_coding | tolerated(1) | possibly_damaging(0.629) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WNT5A | SNV | Missense_Mutation | rs201975128 | c.983N>T | p.Thr328Met | p.T328M | P41221 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WNT5A | SNV | Missense_Mutation | c.928N>A | p.Val310Met | p.V310M | P41221 | protein_coding | tolerated(0.13) | benign(0.051) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WNT5A | SNV | Missense_Mutation | c.306A>C | p.Lys102Asn | p.K102N | P41221 | protein_coding | tolerated(0.1) | possibly_damaging(0.529) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
WNT5A | SNV | Missense_Mutation | c.1021N>T | p.Gly341Cys | p.G341C | P41221 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
WNT5A | SNV | Missense_Mutation | c.928N>A | p.Val310Met | p.V310M | P41221 | protein_coding | tolerated(0.13) | benign(0.051) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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