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Gene: UTP23 |
Gene summary for UTP23 |
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Gene information | Species | Human | Gene symbol | UTP23 | Gene ID | 84294 |
Gene name | UTP23 small subunit processome component | |
Gene Alias | C8orf53 | |
Cytomap | 8q24.11 | |
Gene Type | protein-coding | GO ID | GO:0000462 | UniProtAcc | Q9BRU9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84294 | UTP23 | LZE2T | Human | Esophagus | ESCC | 5.52e-04 | 4.67e-01 | 0.082 |
84294 | UTP23 | LZE4T | Human | Esophagus | ESCC | 3.56e-09 | 3.46e-01 | 0.0811 |
84294 | UTP23 | LZE7T | Human | Esophagus | ESCC | 3.78e-06 | 4.69e-01 | 0.0667 |
84294 | UTP23 | LZE8T | Human | Esophagus | ESCC | 7.04e-06 | 1.81e-01 | 0.067 |
84294 | UTP23 | LZE20T | Human | Esophagus | ESCC | 1.18e-12 | 3.51e-01 | 0.0662 |
84294 | UTP23 | LZE24T | Human | Esophagus | ESCC | 4.91e-23 | 5.65e-01 | 0.0596 |
84294 | UTP23 | LZE6T | Human | Esophagus | ESCC | 5.52e-04 | 1.87e-01 | 0.0845 |
84294 | UTP23 | P1T-E | Human | Esophagus | ESCC | 2.46e-05 | 3.53e-01 | 0.0875 |
84294 | UTP23 | P2T-E | Human | Esophagus | ESCC | 7.73e-29 | 5.25e-01 | 0.1177 |
84294 | UTP23 | P4T-E | Human | Esophagus | ESCC | 9.14e-28 | 6.74e-01 | 0.1323 |
84294 | UTP23 | P5T-E | Human | Esophagus | ESCC | 7.47e-32 | 6.30e-01 | 0.1327 |
84294 | UTP23 | P8T-E | Human | Esophagus | ESCC | 6.91e-24 | 4.24e-01 | 0.0889 |
84294 | UTP23 | P9T-E | Human | Esophagus | ESCC | 1.36e-22 | 5.13e-01 | 0.1131 |
84294 | UTP23 | P10T-E | Human | Esophagus | ESCC | 1.69e-37 | 6.70e-01 | 0.116 |
84294 | UTP23 | P11T-E | Human | Esophagus | ESCC | 1.43e-18 | 5.79e-01 | 0.1426 |
84294 | UTP23 | P12T-E | Human | Esophagus | ESCC | 1.35e-37 | 7.25e-01 | 0.1122 |
84294 | UTP23 | P15T-E | Human | Esophagus | ESCC | 4.37e-27 | 5.71e-01 | 0.1149 |
84294 | UTP23 | P16T-E | Human | Esophagus | ESCC | 4.85e-52 | 9.10e-01 | 0.1153 |
84294 | UTP23 | P17T-E | Human | Esophagus | ESCC | 4.78e-12 | 3.21e-01 | 0.1278 |
84294 | UTP23 | P19T-E | Human | Esophagus | ESCC | 3.46e-06 | 5.54e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00004623 | Esophagus | ESCC | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 32/8552 | 37/18723 | 2.96e-07 | 4.23e-06 | 32 |
GO:00004693 | Esophagus | ESCC | cleavage involved in rRNA processing | 24/8552 | 27/18723 | 3.48e-06 | 3.84e-05 | 24 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
GO:00004783 | Esophagus | ESCC | endonucleolytic cleavage involved in rRNA processing | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00004793 | Esophagus | ESCC | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UTP23 | SNV | Missense_Mutation | c.317C>A | p.Ser106Tyr | p.S106Y | Q9BRU9 | protein_coding | deleterious(0) | possibly_damaging(0.726) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
UTP23 | SNV | Missense_Mutation | novel | c.302N>T | p.Ser101Leu | p.S101L | Q9BRU9 | protein_coding | deleterious(0.01) | benign(0.193) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
UTP23 | SNV | Missense_Mutation | rs752871869 | c.694N>T | p.Arg232Trp | p.R232W | Q9BRU9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UTP23 | SNV | Missense_Mutation | novel | c.369N>T | p.Gln123His | p.Q123H | Q9BRU9 | protein_coding | tolerated(0.23) | possibly_damaging(0.818) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UTP23 | SNV | Missense_Mutation | c.161T>C | p.Met54Thr | p.M54T | Q9BRU9 | protein_coding | tolerated(0.4) | benign(0.313) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
UTP23 | SNV | Missense_Mutation | c.702N>T | p.Arg234Ser | p.R234S | Q9BRU9 | protein_coding | tolerated_low_confidence(0.13) | benign(0.122) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UTP23 | SNV | Missense_Mutation | c.400N>C | p.Gly134Arg | p.G134R | Q9BRU9 | protein_coding | deleterious(0) | possibly_damaging(0.448) | TCGA-NH-A50T-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UTP23 | insertion | Nonsense_Mutation | novel | c.241_242insAATAGTCGATTTTT | p.Leu81GlnfsTer2 | p.L81Qfs*2 | Q9BRU9 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
UTP23 | SNV | Missense_Mutation | novel | c.458A>C | p.Lys153Thr | p.K153T | Q9BRU9 | protein_coding | tolerated(0.31) | benign(0.001) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UTP23 | SNV | Missense_Mutation | c.702A>T | p.Arg234Ser | p.R234S | Q9BRU9 | protein_coding | tolerated_low_confidence(0.13) | benign(0.122) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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