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Gene: UGT1A10 |
Gene summary for UGT1A10 |
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Gene information | Species | Human | Gene symbol | UGT1A10 | Gene ID | 54575 |
Gene name | UDP glucuronosyltransferase family 1 member A10 | |
Gene Alias | GNT1 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006063 | UniProtAcc | Q5DT02 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54575 | UGT1A10 | LZE2T | Human | Esophagus | ESCC | 9.54e-06 | 5.62e-01 | 0.082 |
54575 | UGT1A10 | LZE4T | Human | Esophagus | ESCC | 2.35e-12 | 3.71e-01 | 0.0811 |
54575 | UGT1A10 | LZE8T | Human | Esophagus | ESCC | 3.19e-08 | 3.17e-01 | 0.067 |
54575 | UGT1A10 | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.75e-01 | 0.0662 |
54575 | UGT1A10 | LZE21D1 | Human | Esophagus | HGIN | 5.38e-03 | 2.97e-01 | 0.0632 |
54575 | UGT1A10 | LZE24T | Human | Esophagus | ESCC | 2.32e-20 | 6.54e-01 | 0.0596 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:00424401 | Esophagus | ESCC | pigment metabolic process | 50/8552 | 84/18723 | 7.34e-03 | 2.64e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UGT1A10 | SNV | Missense_Mutation | c.557C>T | p.Pro186Leu | p.P186L | Q9HAW8 | protein_coding | deleterious(0.01) | benign(0.12) | TCGA-AR-A1AH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | PD | ||
UGT1A10 | SNV | Missense_Mutation | c.80N>T | p.Lys27Met | p.K27M | Q9HAW8 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-C8-A27A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
UGT1A10 | SNV | Missense_Mutation | c.643N>A | p.Glu215Lys | p.E215K | Q9HAW8 | protein_coding | tolerated(0.29) | benign(0.029) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UGT1A10 | SNV | Missense_Mutation | c.422N>A | p.Ser141Tyr | p.S141Y | Q9HAW8 | protein_coding | deleterious(0.03) | possibly_damaging(0.845) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
UGT1A10 | insertion | Frame_Shift_Ins | novel | c.508_509insG | p.Ile172AsnfsTer7 | p.I172Nfs*7 | Q9HAW8 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
UGT1A10 | SNV | Missense_Mutation | novel | c.227N>A | p.Thr76Asn | p.T76N | Q9HAW8 | protein_coding | deleterious(0.04) | benign(0.084) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
UGT1A10 | SNV | Missense_Mutation | novel | c.311N>A | p.Ser104Asn | p.S104N | Q9HAW8 | protein_coding | tolerated(0.51) | benign(0.012) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
UGT1A10 | SNV | Missense_Mutation | rs200910522 | c.802A>G | p.Asn268Asp | p.N268D | Q9HAW8 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT1A10 | SNV | Missense_Mutation | rs777228086 | c.392N>A | p.Arg131Gln | p.R131Q | Q9HAW8 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
UGT1A10 | SNV | Missense_Mutation | novel | c.431N>T | p.Ala144Val | p.A144V | Q9HAW8 | protein_coding | tolerated(0.36) | probably_damaging(0.967) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | ANTINEOPLASTIC AGENT | 8689427 | ||
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | mycophenolic acid | 24220207 | ||
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | oxcarbazepine | OXCARBAZEPINE | 27900402 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | allopurinol | ALLOPURINOL | 27798726 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | febuxostat | FEBUXOSTAT | 27798726 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | ETOPOSIDE | ETOPOSIDE | 12695347 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | TROGLITAZONE | TROGLITAZONE | 12433820 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | PHENOBARBITAL | PHENOBARBITAL | 8263600 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | MYCOPHENOLIC ACID | 15039300,10688250 | ||
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | DICLOFENAC | DICLOFENAC | 8511777 |
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